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    MCU Mitochondrial calcium uniporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 59223, updated on 11-Apr-2024

    Summary

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    Official Symbol
    MCUprovided by FlyBase
    Official Full Name
    Mitochondrial calcium uniporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0042185
    Locus tag
    Dmel_CG18769
    See related
    AllianceGenome:FB:FBgn0042185
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG18769; CG8352; dMCU1; Dmel\CG18769; mcu; Mcu
    Summary
    Predicted to enable calcium channel activity and uniporter activity. Involved in several processes, including calcium import into the mitochondrion; memory; and mitochondrial calcium ion homeostasis. Located in mitochondrion. Is expressed in adult brain; adult head; adult optic lobe; and organism. Orthologous to several human genes including MCU (mitochondrial calcium uniporter). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MCU in Genome Data Viewer
    Location:
    65B4-65B5; 3-17 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (6550738..6593940)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (6543838..6587040)

    Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene sulfateless Neighboring gene long non-coding RNA:CR46500 Neighboring gene beta-Tubulin at 65B Neighboring gene javelin Neighboring gene long non-coding RNA:CR45418 Neighboring gene nudel Neighboring gene RNA exonuclease 5 Neighboring gene zero population growth

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Oxidative stress modulates rearrangement of endoplasmic reticulum-mitochondria contacts and calcium dysregulation in a Friedreich's ataxia model. Rodríguez LR, et al. Redox Biol, 2020 Oct. PMID 33128998, Free PMC Article
    2. Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila. Drago I, et al. Cell Rep, 2016 Sep 6. PMID 27568554, Free PMC Article
    3. Activity of the mitochondrial calcium uniporter varies greatly between tissues. Fieni F, et al. Nat Commun, 2012. PMID 23271651, Free PMC Article
    4. Temporal Profiling of the Cortical Synaptic Mitochondrial Proteome Identifies Ageing Associated Regulators of Stability. Graham LC, et al. Cells, 2021 Dec 2. PMID 34943911, Free PMC Article
    5. Genetically targeted 3D visualisation of Drosophila neurons under Electron Microscopy and X-Ray Microscopy using miniSOG. Ng J, et al. Sci Rep, 2016 Dec 13. PMID 27958322, Free PMC Article

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MCU knockout flies are short lived compared to EMRE or MICU3 mutants. MCU loss blocks fast mitochondrial calcium uptake.
      Title: Comprehensive Genetic Characterization of Mitochondrial Ca(2+) Uniporter Components Reveals Their Different Physiological Requirements In Vivo.
    2. These results reveal an in vivo developmental role for the mitochondrial uniporter complex in establishing the necessary structural and functional neuronal substrates for normal memory formation in the adult organism.
      Title: Inhibiting the Mitochondrial Calcium Uniporter during Development Impairs Memory in Adult Drosophila.
    3. Data suggest that MCU plays key role in endoplasmic reticulum-to-mitochondrial calcium transfer and for cell death due to mitochondrial dysfunction under oxidative stress.
      Title: Mitochondrial calcium uniporter in Drosophila transfers calcium between the endoplasmic reticulum and mitochondria in oxidative stress-induced cell death.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables calcium channel activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables calcium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables uniporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables uniporter activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in anesthesia-resistant memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in calcium import into the mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in calcium import into the mitochondrion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in medium-term memory IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial calcium ion homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial calcium ion homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mitochondrial calcium ion transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to oxidative stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    part_of uniplex complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of uniplex complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of uniplex complex TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    mitochondrial calcium uniporter
    Names
    CG18769-PA
    CG18769-PB
    CG18769-PC
    CG18769-PD
    CG18769-PE
    CG18769-PG
    CG18769-PH
    CG18769-PI
    MCU-PA
    MCU-PB
    MCU-PC
    MCU-PD
    MCU-PE
    MCU-PG
    MCU-PH
    MCU-PI

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_037436.4 Reference assembly

      Range
      6550738..6593940
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001259718.1 → NP_001246647.1  mitochondrial calcium uniporter, isoform H [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001246647.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ70
      Conserved Domains (1) summary
      pfam04678
      Location:208 → 410
      MCU; Mitochondrial calcium uniporter

    2. NM_206280.2 → NP_996002.2  mitochondrial calcium uniporter, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996002.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ70
      Conserved Domains (2) summary
      pfam02037
      Location:73 → 105
      SAP; SAP domain
      pfam04678
      Location:194 → 396
      MCU; Mitochondrial calcium uniporter

    3. NM_144449.4 → NP_652706.3  mitochondrial calcium uniporter, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_652706.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1NZC4, M9NF23, Q7KU70, Q8IQ70, X2JAQ2
      Related
      FBpp0076679
      Conserved Domains (1) summary
      pfam04678
      Location:117 → 319
      MCU; Mitochondrial calcium uniporter

    4. NM_168169.3 → NP_729173.1  mitochondrial calcium uniporter, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729173.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1NZC4, M9NF23, Q7KU70, Q8IQ70, X2JAQ2
      Related
      FBpp0076681
      Conserved Domains (1) summary
      pfam04678
      Location:117 → 319
      MCU; Mitochondrial calcium uniporter

    5. NM_206282.2 → NP_996004.1  mitochondrial calcium uniporter, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996004.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1NZC4, M9NF23, Q7KU70, Q8IQ70, X2JAQ2
      Conserved Domains (1) summary
      pfam04678
      Location:117 → 319
      MCU; Mitochondrial calcium uniporter

    6. NM_206281.2 → NP_996003.1  mitochondrial calcium uniporter, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_996003.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ70
      Conserved Domains (1) summary
      pfam04678
      Location:36 → 238
      MCU; Mitochondrial calcium uniporter

    7. NM_168170.2 → NP_729174.2  mitochondrial calcium uniporter, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_729174.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      E1NZC4, M9NF23, Q7KU70, Q8IQ70, X2JAQ2
      Related
      FBpp0076680
      Conserved Domains (1) summary
      pfam04678
      Location:117 → 319
      MCU; Mitochondrial calcium uniporter

    8. NM_001300025.1 → NP_001286954.1  mitochondrial calcium uniporter, isoform I [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001286954.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8IQ70
      Conserved Domains (1) summary
      pfam04678
      Location:116 → 318
      MCU; Mitochondrial calcium uniporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8IQ70.2 Q8IQ70

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