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    RAP2A RAP2A, member of RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 5911, updated on 10-Jun-2024

    Summary

    Official Symbol
    RAP2Aprovided by HGNC
    Official Full Name
    RAP2A, member of RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9861
    See related
    Ensembl:ENSG00000125249 MIM:179540; AllianceGenome:HGNC:9861
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KREV; RAP2; K-REV; RbBP-30
    Summary
    Enables GTPase activity; guanyl ribonucleotide binding activity; and magnesium ion binding activity. Involved in several processes, including actin cytoskeleton reorganization; microvillus assembly; and positive regulation of protein autophosphorylation. Acts upstream of or within establishment of protein localization. Located in plasma membrane and recycling endosome membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in brain (RPKM 41.0), placenta (RPKM 14.5) and 23 other tissues See more
    Orthologs
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    Genomic context

    See RAP2A in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (97434169..97469128)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (96640480..96675445)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (98086423..98121382)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene muscleblind like splicing regulator 2 Neighboring gene uncharacterized LOC101927385 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7888 Neighboring gene Sharpr-MPRA regulatory region 6469 Neighboring gene FOXA motif-containing MPRA enhancer 219 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5450 Neighboring gene RNA, 5S ribosomal pseudogene 37 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:98085607-98086538 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5452 Neighboring gene ReSE screen-validated silencer GRCh37_chr13:98090451-98090644 Neighboring gene NANOG hESC enhancer GRCh37_chr13:98101035-98101536 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7893 Neighboring gene proteasome subunit alpha 6 pseudogene 4 Neighboring gene uncharacterized LOC105370324 Neighboring gene uncharacterized LOC105370325

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag Prostaglandin E2-mediated HIV-1 inhibition requires the EPAC/RAP/RhoA signaling pathway by downregulation of HIV-1 CA production PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GDP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables magnesium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Rap protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Rap protein signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to xenobiotic stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    NOT involved_in establishment of epithelial cell apical/basal polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within establishment of protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microvillus assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein localization to plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of JNK cascade IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of dendrite morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Schaffer collateral - CA1 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Schaffer collateral - CA1 synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in recycling endosome membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rap-2a
    Names
    RAP2, member of RAS oncogene family (K-rev)
    NP_066361.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021033.7NP_066361.1  ras-related protein Rap-2a

      See identical proteins and their annotated locations for NP_066361.1

      Status: VALIDATED

      Source sequence(s)
      AL442067, BC022356, BC041333, BC047495, CB215818, DA493957, DB480985
      Consensus CDS
      CCDS9485.1
      UniProtKB/Swiss-Prot
      B2RCJ1, P10114, Q5JSC1, Q5JSC2
      UniProtKB/TrEMBL
      Q5JQ44
      Related
      ENSP00000245304.3, ENST00000245304.5
      Conserved Domains (1) summary
      cd04176
      Location:3165
      Rap2; Rap2 family GTPase consists of Rap2a, Rap2b, and Rap2c

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      97434169..97469128
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      96640480..96675445
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)