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    Tpm3 tropomyosin 3, gamma [ Mus musculus (house mouse) ]

    Gene ID: 59069, updated on 12-Aug-2018

    Summary

    Official Symbol
    Tpm3provided by MGI
    Official Full Name
    tropomyosin 3, gammaprovided by MGI
    Primary source
    MGI:MGI:1890149
    See related
    Ensembl:ENSMUSG00000027940 Vega:OTTMUSG00000029647
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TMnm; Tpm5; Tm5NM; Tpm-5; hTMnm; TM30nm; Trop-5; hTM30nm; gamma-TM
    Expression
    Ubiquitous expression in placenta adult (RPKM 17.7), CNS E11.5 (RPKM 17.1) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tpm3 in Genome Data Viewer
    Location:
    3; 3 F1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (90072651..90100902)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (89876616..89904526)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933434E20 gene Neighboring gene RIKEN cDNA 1700094D03 gene Neighboring gene microRNA 190b Neighboring gene nucleoporin 210-like Neighboring gene predicted gene, 34865 Neighboring gene ribosomal protein S27

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • Adrenergic signaling in cardiomyocytes, organism-specific biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, organism-specific biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Adrenergic signaling in cardiomyocytes, conserved biosystem (from KEGG)
      Adrenergic signaling in cardiomyocytes, conserved biosystemCardiac myocytes express at least six subtypes of adrenergic receptor (AR) which include three subtypes of beta-AR (beta-1, beta-2, beta-3) and three subtypes of the alpha-1-AR (alpha-1A, alpha-1B, a...
    • Cardiac muscle contraction, organism-specific biosystem (from KEGG)
      Cardiac muscle contraction, organism-specific biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Cardiac muscle contraction, conserved biosystem (from KEGG)
      Cardiac muscle contraction, conserved biosystemContraction of the heart is a complex process initiated by the electrical excitation of cardiac myocytes (excitation-contraction coupling, ECC). In cardiac myocytes, Ca2+ influx induced by activation...
    • Dilated cardiomyopathy, organism-specific biosystem (from KEGG)
      Dilated cardiomyopathy, organism-specific biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Dilated cardiomyopathy, conserved biosystem (from KEGG)
      Dilated cardiomyopathy, conserved biosystemDilated cardiomyopathy (DCM) is a heart muscle disease characterised by dilation and impaired contraction of the left or both ventricles that results in progressive heart failure and sudden cardiac d...
    • Hypertrophic cardiomyopathy (HCM), organism-specific biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), organism-specific biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Hypertrophic cardiomyopathy (HCM), conserved biosystem (from KEGG)
      Hypertrophic cardiomyopathy (HCM), conserved biosystemHypertrophic cardiomyopathy (HCM) is a primary myocardial disorder with an autosomal dominant pattern of inheritance that is characterized by hypertrophy of the left ventricles with histological feat...
    • Muscle contraction, organism-specific biosystem (from REACTOME)
      Muscle contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Pathways in cancer, organism-specific biosystem (from KEGG)
      Pathways in cancer, organism-specific biosystem
      Pathways in cancer
    • Smooth Muscle Contraction, organism-specific biosystem (from REACTOME)
      Smooth Muscle Contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Striated Muscle Contraction, organism-specific biosystem (from REACTOME)
      Striated Muscle Contraction, organism-specific biosystemcomputationally inferred pathway (not manually curated)
    • Striated Muscle Contraction, organism-specific biosystem (from WikiPathways)
      Striated Muscle Contraction, organism-specific biosystem
      Striated Muscle Contraction
    • Thyroid cancer, organism-specific biosystem (from KEGG)
      Thyroid cancer, organism-specific biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...
    • Thyroid cancer, conserved biosystem (from KEGG)
      Thyroid cancer, conserved biosystemThyroid cancer is the most common endocrine malignancy and accounts for the majority of endocrine cancer- related deaths each year. More than 95% of thyroid carcinomas are derived from follicular cel...

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC102590

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin filament binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    actin cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    actin filament IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with cleavage furrow IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cortical cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    growth cone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    neuron projection IDA
    Inferred from Direct Assay
    more info
    PubMed 
    podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    stress fiber ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    tropomyosin alpha-3 chain
    Names
    gamma-tropomyosin
    skalphaTM.2
    tropomyosin 5
    tropomyosin-3

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001253738.1NP_001240667.1  tropomyosin alpha-3 chain isoform Tpm3.1cy

      See identical proteins and their annotated locations for NP_001240667.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3, also known as variant Tpm3.1) represents the use of an alternate promoter and differs in the 5' structure, causing translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.1cy, also known as isoform 3) has a distinct N-terminus and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
      Source sequence(s)
      AK146557, BY284672, BY622941
      Consensus CDS
      CCDS57223.1
      UniProtKB/Swiss-Prot
      P21107
      UniProtKB/TrEMBL
      Q58E70
      Related
      ENSMUSP00000029549.8, OTTMUSP00000038084, ENSMUST00000029549.15, OTTMUST00000073540
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
    2. NM_001253740.1NP_001240669.1  tropomyosin alpha-3 chain isoform Tpm3.2cy

      See identical proteins and their annotated locations for NP_001240669.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4, also known as variant Tpm3.2) represents the use of an alternate promoter and has multiple differences compared to variant Tpm3.13. These differences result in a different 5' UTR and cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.2cy, also known as isoform 4) has a distinct N-terminus and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
      Source sequence(s)
      AK146557, BY284672, BY622941, CX237327
      UniProtKB/TrEMBL
      Q58E70
      Conserved Domains (2) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
      pfam06009
      Location:150229
      Laminin_II; Laminin Domain II
    3. NM_001271764.2NP_001258693.1  tropomyosin alpha-3 chain isoform Tpm3.5cy

      See identical proteins and their annotated locations for NP_001258693.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5, also known as variant Tpm3.5) represents the use of an alternate promoter and has multiple differences compared to variant Tpm3.13. These differences result in different 5' and 3' UTRs and cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.5cy, also known as isoform 5) has distinct N- and C- termini and is shorter than isoform Tpm3.13cy. Isoforms Tpm3.1cy, Tpm3.2cy, and Tpm3.5cy are the same length, but contain distinct C-termini.
      Source sequence(s)
      AI842950, AK050665, BB690682, BY284672
      UniProtKB/TrEMBL
      Q8C7C3
      Conserved Domains (2) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
      pfam07851
      Location:144238
      TMPIT; TMPIT-like protein
    4. NM_001293748.1NP_001280677.2  tropomyosin alpha-3 chain isoform Tpm3.12st

      See identical proteins and their annotated locations for NP_001280677.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2, also known as variant Tpm3.12) differs in the 3' UTR and has multiple differences in the 3' coding region compared to variant Tpm3.13. The encoded isoform (Tpm3.12st, also known as isoform 2) is the same length as isoform Tpm3.13cy, but contains a distinct C-terminal segment. The encoded protein is the fast skeletal muscle isoform.
      Source sequence(s)
      AC163616
      UniProtKB/Swiss-Prot
      P21107
      Related
      ENSMUSP00000113578.1, OTTMUSP00000038083, ENSMUST00000121503.7, OTTMUST00000073539
      Conserved Domains (2) summary
      pfam00261
      Location:49283
      Tropomyosin; Tropomyosin
      pfam16526
      Location:1473
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels
    5. NM_001293749.1NP_001280678.1  tropomyosin alpha-3 chain isoform Tpm3.4cy

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6, also known as variant Tpm3.4) represents the use of an alternate promoter, differs in the 5' and 3' structures and has multiple differences in the coding region compared to variant Tpm3.13. These differences cause translation initiation at an alternate start codon compared to variant Tpm3.13. The encoded isoform (Tpm3.4cy, also known as isoform 6) has distinct N- and C- termini and is shorter than isoform Tpm3.13cy.
      Source sequence(s)
      AC163616, BF464045
      Consensus CDS
      CCDS79961.1
      UniProtKB/TrEMBL
      D3Z6I8
      Related
      ENSMUSP00000113219.1, OTTMUSP00000038133, ENSMUST00000119158.7, OTTMUST00000073606
      Conserved Domains (1) summary
      pfam00261
      Location:12245
      Tropomyosin; Tropomyosin
    6. NM_001357581.1NP_001344510.1  tropomyosin alpha-3 chain isoform Tpm3.3cy

      Status: VALIDATED

      Source sequence(s)
      AC163616, AI842950
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
    7. NM_022314.3NP_071709.3  tropomyosin alpha-3 chain isoform Tpm3.13cy

      See identical proteins and their annotated locations for NP_071709.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1, also known as variant Tpm3.13) encodes isoform Tpm3.13cy (also known as isoform 1). This isoform is the same length as isoform Tpm3.12st, but contains a distinct C-terminal segment.
      Source sequence(s)
      AK146557, BC029186, BY622941, BY770803
      Consensus CDS
      CCDS38499.2
      UniProtKB/TrEMBL
      E9Q5J9, Q58E70, Q8K0Z5
      Related
      ENSMUSP00000113978.1, OTTMUSP00000038082, ENSMUST00000119570.7, OTTMUST00000073538
      Conserved Domains (2) summary
      pfam00261
      Location:49283
      Tropomyosin; Tropomyosin
      pfam16526
      Location:1473
      CLZ; C-terminal leucine zipper domain of cyclic nucleotide-gated channels

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      90072651..90100902
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006501839.2XP_006501902.1  tropomyosin alpha-3 chain isoform X6

      Conserved Domains (1) summary
      pfam00261
      Location:12245
      Tropomyosin; Tropomyosin
    2. XM_017319678.1XP_017175167.1  tropomyosin alpha-3 chain isoform X4

      UniProtKB/TrEMBL
      E9Q7Q3
      Related
      ENSMUSP00000113056.1, OTTMUSP00000038085, ENSMUST00000118566.7, OTTMUST00000073541
      Conserved Domains (1) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
    3. XM_006501835.2XP_006501898.1  tropomyosin alpha-3 chain isoform X1

      Conserved Domains (2) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
      pfam07851
      Location:144238
      TMPIT; TMPIT-like protein
    4. XM_006501836.2XP_006501899.1  tropomyosin alpha-3 chain isoform X2

      Conserved Domains (2) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
      pfam07851
      Location:144238
      TMPIT; TMPIT-like protein
    5. XM_017319677.1XP_017175166.1  tropomyosin alpha-3 chain isoform X3

      UniProtKB/TrEMBL
      Q8C7C3
      Conserved Domains (2) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
      pfam07851
      Location:144238
      TMPIT; TMPIT-like protein
    6. XM_006501838.1XP_006501901.1  tropomyosin alpha-3 chain isoform X5

      Conserved Domains (2) summary
      pfam00261
      Location:12246
      Tropomyosin; Tropomyosin
      pfam07851
      Location:144238
      TMPIT; TMPIT-like protein
    7. XM_006501841.3XP_006501904.1  tropomyosin alpha-3 chain isoform X7

      Conserved Domains (1) summary
      pfam10473
      Location:35181
      CENP-F_leu_zip; Leucine-rich repeats of kinetochore protein Cenp-F/LEK1

    RNA

    1. XR_001783731.1 RNA Sequence

    2. XR_001783732.1 RNA Sequence

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