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    Ppp2r3c protein phosphatase 2, regulatory subunit B'', gamma [ Mus musculus (house mouse) ]

    Gene ID: 59032, updated on 23-Jun-2021

    Summary

    Official Symbol
    Ppp2r3cprovided by MGI
    Official Full Name
    protein phosphatase 2, regulatory subunit B'', gammaprovided by MGI
    Primary source
    MGI:MGI:1930009
    See related
    Ensembl:ENSMUSG00000021022
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    G5; G4-1; G5pr; 4930511A21Rik; 5730412A08Rik
    Expression
    Broad expression in CNS E11.5 (RPKM 10.4), CNS E14 (RPKM 10.1) and 24 other tissues See more
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    Genomic context

    See Ppp2r3c in Genome Data Viewer
    Location:
    12; 12 C1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (55327594..55350024, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (55280809..55303239, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 12 NC_000078.5 (56381801..56403987, complement)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 177 member A2 Neighboring gene predicted gene 2446 Neighboring gene signal recognition particle 54C Neighboring gene protein only RNase P catalytic subunit Neighboring gene ribosomal protein L18A, pseudogene 1 Neighboring gene proteasome subunit alpha 6 Neighboring gene mitochondrial import inner membrane translocase subunit Tim8 B pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1)  1 citation
    • Endonuclease-mediated (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in B cell homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within B cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in T cell homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within T cell homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within activation of protein kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cortical cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of B cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of B cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of B cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of antimicrobial humoral response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of dephosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of mitochondrial depolarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within spleen development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma
    Names
    phosphatase subunit gene g4-1
    protein phosphatase subunit G5PR

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021529.4NP_067504.2  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma

      See identical proteins and their annotated locations for NP_067504.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the protein-coding transcript.
      Source sequence(s)
      AC166323
      Consensus CDS
      CCDS36450.1
      UniProtKB/Swiss-Prot
      Q9JK24
      Related
      ENSMUSP00000021410.9, ENSMUST00000021410.10
      Conserved Domains (1) summary
      pfam17958
      Location:184258
      EF-hand_13; EF-hand domain

    RNA

    1. NR_168549.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166323
    2. NR_168550.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166323
    3. NR_168551.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166323
    4. NR_168552.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC166323

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      55327594..55350024 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030246828.1XP_030102688.1  serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma isoform X1

      Conserved Domains (1) summary
      pfam17958
      Location:184258
      EF-hand_13; EF-hand domain
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