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    Edf1 endothelial differentiation-related factor 1 [ Mus musculus (house mouse) ]

    Gene ID: 59022, updated on 26-Sep-2022

    Summary

    Official Symbol
    Edf1provided by MGI
    Official Full Name
    endothelial differentiation-related factor 1provided by MGI
    Primary source
    MGI:MGI:1891227
    See related
    Ensembl:ENSMUSG00000015092 AllianceGenome:MGI:1891227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MBF1; 0610008L11Rik
    Summary
    Predicted to enable TFIID-class transcription factor complex binding activity and transcription coactivator activity. Predicted to be involved in positive regulation of DNA binding activity. Predicted to act upstream of or within cell differentiation. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; genitourinary system; heart; liver; and retina. Orthologous to human EDF1 (endothelial differentiation related factor 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in small intestine adult (RPKM 103.6), duodenum adult (RPKM 81.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Edf1 in Genome Data Viewer
    Location:
    2; 2 A3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (25447838..25452096)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (25557824..25562084)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TNF receptor-associated factor 2 Neighboring gene cytochrome c oxidase subunit 7A2, mitochondrial pseudogene Neighboring gene predicted gene, 35476 Neighboring gene MAM domain containing 4 Neighboring gene phosphohistidine phosphatase 1 Neighboring gene apical junction component 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables TFIID-class transcription factor complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables calmodulin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    endothelial differentiation-related factor 1
    Names
    hypothetical protein 1-9
    multiprotein-bridging factor 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021519.2NP_067494.1  endothelial differentiation-related factor 1

      See identical proteins and their annotated locations for NP_067494.1

      Status: VALIDATED

      Source sequence(s)
      AB030185, BB856073, CF740336
      Consensus CDS
      CCDS15780.1
      UniProtKB/Swiss-Prot
      Q99NE6, Q9JMG1
      UniProtKB/TrEMBL
      A0A6P5PCC1, A0A8C6HTD4
      Related
      ENSMUSP00000015236.4, ENSMUST00000015236.4
      Conserved Domains (2) summary
      cl26727
      Location:48142
      aMBF1; Archaeal ribosome-binding protein aMBF1, putative translation factor, contains Zn-ribbon and HTH domains [Translation, ribosomal structure and biogenesis]
      pfam08523
      Location:571
      MBF1; Multiprotein bridging factor 1

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      25447838..25452096
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030251920.2XP_030107780.1  endothelial differentiation-related factor 1 isoform X1

      Conserved Domains (1) summary
      pfam08523
      Location:472
      MBF1; Multiprotein bridging factor 1