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    Rab2a RAB2A, member RAS oncogene family [ Mus musculus (house mouse) ]

    Gene ID: 59021, updated on 22-Sep-2022

    Summary

    Official Symbol
    Rab2aprovided by MGI
    Official Full Name
    RAB2A, member RAS oncogene familyprovided by MGI
    Primary source
    MGI:MGI:1928750
    See related
    Ensembl:ENSMUSG00000047187 AllianceGenome:MGI:1928750
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rab2; 9330148M11Rik
    Summary
    Predicted to enable GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Golgi organization. Predicted to act upstream of or within intracellular protein transport. Located in Golgi apparatus. Is expressed in dorsal root ganglion; eye; foregut; limb; and limb mesenchyme. Orthologous to human RAB2A (RAB2A, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 79.3), adrenal adult (RPKM 75.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Rab2a in Genome Data Viewer
    Location:
    4; 4 A1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (8535178..8607702)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (8535469..8607702)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (8462791..8534849)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene predicted gene 11810 Neighboring gene ribosomal protein L23 pseudogene Neighboring gene predicted gene, 42253 Neighboring gene predicted gene 8273

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables GDP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTP binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTP binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within intracellular protein transport TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    ras-related protein Rab-2A
    Names
    GTP-binding protein
    RAB2, member RAS oncogene family
    NP_067493.1
    XP_006538189.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001411827.1NP_001398756.1  ras-related protein Rab-2A isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL732627, AL806521
    2. NM_001411828.1NP_001398757.1  ras-related protein Rab-2A isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL732627, AL806521
    3. NM_021518.4NP_067493.1  ras-related protein Rab-2A isoform 1

      See identical proteins and their annotated locations for NP_067493.1

      Status: VALIDATED

      Source sequence(s)
      AL732627, AL806521
      Consensus CDS
      CCDS17955.1
      UniProtKB/Swiss-Prot
      P53994, Q3UK45
      UniProtKB/TrEMBL
      A0A6P5PQR6, A0A8C6I4Q9, Q0PD65
      Related
      ENSMUSP00000057664.8, ENSMUST00000060232.8
      Conserved Domains (1) summary
      cl27030
      Location:1212
      Ras; Ras family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      8535178..8607702
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538126.5XP_006538189.1  ras-related protein Rab-2A isoform X1

      Conserved Domains (1) summary
      cd01866
      Location:3158
      Rab2; Rab GTPase family 2 (Rab2)