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    RAN RAN, member RAS oncogene family [ Homo sapiens (human) ]

    Gene ID: 5901, updated on 9-Jun-2024

    Summary

    Official Symbol
    RANprovided by HGNC
    Official Full Name
    RAN, member RAS oncogene familyprovided by HGNC
    Primary source
    HGNC:HGNC:9846
    See related
    Ensembl:ENSG00000132341 MIM:601179; AllianceGenome:HGNC:9846
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TC4; Gsp1; ARA24
    Summary
    RAN (ras-related nuclear protein) is a small GTP binding protein belonging to the RAS superfamily that is essential for the translocation of RNA and proteins through the nuclear pore complex. The RAN protein is also involved in control of DNA synthesis and cell cycle progression. Nuclear localization of RAN requires the presence of regulator of chromosome condensation 1 (RCC1). Mutations in RAN disrupt DNA synthesis. Because of its many functions, it is likely that RAN interacts with several other proteins. RAN regulates formation and organization of the microtubule network independently of its role in the nucleus-cytosol exchange of macromolecules. RAN could be a key signaling molecule regulating microtubule polymerization during mitosis. RCC1 generates a high local concentration of RAN-GTP around chromatin which, in turn, induces the local nucleation of microtubules. RAN is an androgen receptor (AR) coactivator that binds differentially with different lengths of polyglutamine within the androgen receptor. Polyglutamine repeat expansion in the AR is linked to Kennedy's disease (X-linked spinal and bulbar muscular atrophy). RAN coactivation of the AR diminishes with polyglutamine expansion within the AR, and this weak coactivation may lead to partial androgen insensitivity during the development of Kennedy's disease. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in lymph node (RPKM 71.4), testis (RPKM 70.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RAN in Genome Data Viewer
    Location:
    12q24.33
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (130872066..130877678)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (130911164..130916776)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (131356611..131362223)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903053 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:131337941-131338691 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:131338692-131339442 Neighboring gene H3K27ac hESC enhancer GRCh37_chr12:131339443-131340192 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr12:131355651-131356412 and GRCh37_chr12:131356413-131357174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7349 Neighboring gene RNA, U6 small nuclear 1077, pseudogene Neighboring gene Sharpr-MPRA regulatory region 1775 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7352 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7353 Neighboring gene Sharpr-MPRA regulatory region 4789 Neighboring gene uncharacterized LOC124903054 Neighboring gene adhesion G protein-coupled receptor D1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:131464091-131465081 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_25923 Neighboring gene ADGRD1 antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify GTP binding protein RAN (RanGTP), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    gag Ran terminates the nuclear import of the Matrix protein of HIV-1 Gag by directly binding to karyopherin beta and disassembling the import complex PubMed
    Rev rev the GTP bound form of Ran (RanGTP) binds to a preformed Rev-CRM1 (exportin 1) complex to mediate nuclear export of HIV-1 mRNA PubMed
    rev A dimeric CRM1-RanGTP complex binds a Rev-RRE complex to export the Rev-RRE complex from the nuclear to the cytoplasm in cells PubMed
    rev HIV-1 Rev interacting protein, RAN, is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa cells PubMed
    rev Rev-Rev interactions (multimerization) are enhanced by RanGTP PubMed
    rev binding of the GTP bound form of Ran (RanGTP) to a preformed Rev-CRM1 complex is linked to an interaction of RanGTP with the nuclear export signal (NES) of Rev (amino acids 75-83) PubMed
    Tat tat Interaction of HIV-1 Tat with RAN in T-cells is identified by a proteomic strategy based on affinity chromatography PubMed
    capsid gag RanGTP inhibits the ability of TNPO3 to stimulate the uncoating of HIV-1 CA cores PubMed
    integrase gag-pol The binding between HIV-1 IN and TNPO3 is inhibited by RanGTP in a dose-dependent manner, leading to a TNPO3-RanGTP complex formation PubMed
    matrix gag Ran terminates the nuclear import of HIV-1 Matrix by directly binding to karyopherin beta and disassembling the import complex PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GDP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTP binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables GTPase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables cadherin binding HDA PubMed 
    enables chromatin binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables dynein intermediate chain binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables importin-alpha family protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to nuclear export signal receptor activity IC
    Inferred by Curator
    more info
    PubMed 
    contributes_to pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA metabolic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in GTP metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to mineralocorticoid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in hippocampus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic sister chromatid segregation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle organization TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of protein binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in pre-miRNA export from nucleus IC
    Inferred by Curator
    more info
    PubMed 
    involved_in protein export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein import into nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein localization to nucleolus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal large subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal small subunit export from nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in ribosomal subunit export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in snRNA import into nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatid development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in viral process TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    NOT located_in Flemming body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RNA nuclear export complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriole IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in male germ cell nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in manchette IEA
    Inferred from Electronic Annotation
    more info
     
    located_in melanosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear envelope IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of nuclear pore NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in recycling endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm flagellum IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    GTP-binding nuclear protein Ran
    Names
    GTPase Ran
    RanGTPase
    androgen receptor-associated protein 24
    guanosine triphosphatase Ran
    member RAS oncogene family
    ras-like protein TC4
    ras-related nuclear protein
    NP_001287725.1
    NP_001287726.1
    NP_006316.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001300796.2NP_001287725.1  GTP-binding nuclear protein Ran isoform 2

      See identical proteins and their annotated locations for NP_001287725.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC073912, AF054183, AK316193
      Consensus CDS
      CCDS73546.1
      UniProtKB/TrEMBL
      B4DV51
      Related
      ENSP00000441210.1, ENST00000541630.5
      Conserved Domains (1) summary
      smart00176
      Location:1127
      RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
    2. NM_001300797.2NP_001287726.1  GTP-binding nuclear protein Ran isoform 2

      See identical proteins and their annotated locations for NP_001287726.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1. Variants 2 and 3 encode the same protein.
      Source sequence(s)
      AC073912, AK300934, HY139187
      Consensus CDS
      CCDS73546.1
      UniProtKB/TrEMBL
      B4DV51
      Conserved Domains (1) summary
      smart00176
      Location:1127
      RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases
    3. NM_006325.5NP_006316.1  GTP-binding nuclear protein Ran isoform 1

      See identical proteins and their annotated locations for NP_006316.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC073912, AF054183, BC000852
      Consensus CDS
      CCDS9271.1
      UniProtKB/Swiss-Prot
      A8K3Z8, P17080, P28746, P28747, P62826, Q6IPB2, Q86V08, Q8NI90, Q9CSP3, Q9CWI7, Q9CZA2, Q9UDJ5, Q9UEU9
      UniProtKB/TrEMBL
      B5MDF5
      Related
      ENSP00000446215.1, ENST00000543796.6
      Conserved Domains (1) summary
      smart00176
      Location:16215
      RAN; Ran (Ras-related nuclear proteins) /TC4 subfamily of small GTPases

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      130872066..130877678
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      130911164..130916776
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)