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    Sh3rf1 SH3 domain containing ring finger 1 [ Mus musculus (house mouse) ]

    Gene ID: 59009, updated on 8-Aug-2021

    Summary

    Official Symbol
    Sh3rf1provided by MGI
    Official Full Name
    SH3 domain containing ring finger 1provided by MGI
    Primary source
    MGI:MGI:1913066
    See related
    Ensembl:ENSMUSG00000031642
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; Posh; Sh3md; R75531; Sh3md2; 2200003J05Rik
    Expression
    Ubiquitous expression in whole brain E14.5 (RPKM 9.0), lung adult (RPKM 8.7) and 27 other tissues See more
    Orthologs
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    Genomic context

    See Sh3rf1 in Genome Data Viewer
    Location:
    8; 8 B3.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (61677117..61918327)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (61224083..61465293)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (63702968..63874869)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 18394 Neighboring gene chloride channel, voltage-sensitive 3 Neighboring gene NIMA (never in mitosis gene a)-related expressed kinase 1 Neighboring gene RIKEN cDNA 1700001D01 gene Neighboring gene RIKEN cDNA 5730405A17 gene Neighboring gene predicted gene, 40499 Neighboring gene predicted gene 10015 Neighboring gene ribosomal protein S2 pseudogene Neighboring gene predicted gene, 53435 Neighboring gene carbonyl reductase 4 Neighboring gene palladin, cytoskeletal associated protein Neighboring gene predicted gene, 35254

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables MAP-kinase scaffold activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase SH3RF1
    Names
    RING-type E3 ubiquitin transferase SH3RF1
    SH3 domain-containing RING finger protein 1
    SH3 multiple domains 2
    SH3 multiple domains protein 2
    plenty of SH3 domains
    plenty of SH3s
    putative E3 ubiquitin-protein ligase SH3RF1
    NP_067481.2
    XP_011240533.1
    XP_036010097.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021506.2NP_067481.2  E3 ubiquitin-protein ligase SH3RF1

      Status: VALIDATED

      Source sequence(s)
      AC117196, AC134339, AK045470, BY741307, CO040875
      Consensus CDS
      CCDS40348.1
      UniProtKB/Swiss-Prot
      Q69ZI1
      UniProtKB/TrEMBL
      E9QQ33
      Related
      ENSMUSP00000034060.6, ENSMUST00000034060.7
      Conserved Domains (5) summary
      cd11785
      Location:836890
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11930
      Location:200254
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      PHA03247
      Location:539851
      PHA03247; large tegument protein UL36; Provisional
      cd16748
      Location:855
      RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
      cl17036
      Location:455509
      SH3; Src Homology 3 domain superfamily

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      61677117..61918327
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011242231.2XP_011240533.1  E3 ubiquitin-protein ligase SH3RF1 isoform X2

      Related
      ENSMUSP00000148118.2, ENSMUST00000209611.2
      Conserved Domains (5) summary
      cd11930
      Location:200254
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      PHA03247
      Location:539832
      PHA03247; large tegument protein UL36; Provisional
      cd00162
      Location:1252
      RING_Ubox; RING-HC finger (C3HC4-type) [structural motif]
      cl17036
      Location:455509
      SH3; Src Homology 3 domain superfamily
      cl17238
      Location:855
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    2. XM_036154204.1XP_036010097.1  E3 ubiquitin-protein ligase SH3RF1 isoform X1

      Conserved Domains (5) summary
      cd11785
      Location:836890
      SH3_SH3RF_C; C-terminal (Fourth) Src Homology 3 domain of SH3 domain containing ring finger 1 (SH3RF1), SH3RF3, and similar domains
      cd11930
      Location:200254
      SH3_SH3RF1_2; Second Src Homology 3 domain of SH3 domain containing ring finger protein 1, an E3 ubiquitin-protein ligase
      PHA03247
      Location:539851
      PHA03247; large tegument protein UL36; Provisional
      cd16748
      Location:855
      RING-HC_SH3RF1; RING finger, HC subclass, found in SH3 domain-containing RING finger protein 1 (SH3RF1) and similar proteins
      cl17036
      Location:455509
      SH3; Src Homology 3 domain superfamily

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_198678.1: Suppressed sequence

      Description
      NM_198678.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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