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    Ngly1 N-glycanase 1 [ Mus musculus (house mouse) ]

    Gene ID: 59007, updated on 21-Sep-2021

    Summary

    Official Symbol
    Ngly1provided by MGI
    Official Full Name
    N-glycanase 1provided by MGI
    Primary source
    MGI:MGI:1913276
    See related
    Ensembl:ENSMUSG00000021785
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Pn; Png1; PNGase; 1110002C09Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 30.1), adrenal adult (RPKM 10.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Ngly1 in Genome Data Viewer
    Location:
    14 A1; 14 7.08 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (6157837..6220449, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (16249314..16311926)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (17081828..17144440)

    Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene retinoic acid receptor, beta Neighboring gene predicted gene, 53820 Neighboring gene predicted gene, 46442 Neighboring gene topoisomerase (DNA) II beta Neighboring gene ribosomal protein L31, pseudogene 3 Neighboring gene 3-oxoacyl-ACP synthase, mitochondrial Neighboring gene ribosomal protein L4 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (6)  1 citation
    • Endonuclease-mediated (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ER-associated misfolded protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in glycoprotein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in glycoprotein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in glycoprotein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein deglycosylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein deglycosylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein quality control for misfolded or incompletely synthesized proteins IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in collagen-containing extracellular matrix HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 

    General protein information

    Preferred Names
    peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase
    Names
    peptide N-glycanase homolog
    NP_001349361.1
    NP_001349362.1
    NP_067479.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362432.1NP_001349361.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC173482, AK148931, BC028961
      Conserved Domains (4) summary
      pfam03835
      Location:316400
      Rad4; Rad4 transglutaminase-like domain
      pfam01841
      Location:253332
      Transglut_core; Transglutaminase-like superfamily
      pfam04721
      Location:435629
      PAW; PNGase C-terminal domain, mannose-binding module PAW
      cl15262
      Location:2690
      PUB; PNGase/UBA or UBX (PUB) domain of p97 adaptor proteins
    2. NM_001362433.1NP_001349362.1  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC173482, AK028248, AK169205, BC028961
      Consensus CDS
      CCDS88581.1
      Related
      ENSMUSP00000152998.2, ENSMUST00000224656.2
      Conserved Domains (4) summary
      cd10459
      Location:19109
      PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
      pfam03835
      Location:335420
      Rad4; Rad4 transglutaminase-like domain
      pfam01841
      Location:272351
      Transglut_core; Transglutaminase-like superfamily
      pfam04721
      Location:413593
      PAW; PNGase C-terminal domain, mannose-binding module PAW
    3. NM_021504.3NP_067479.2  peptide-N(4)-(N-acetyl-beta-glucosaminyl)asparagine amidase isoform 1

      See identical proteins and their annotated locations for NP_067479.2

      Status: VALIDATED

      Source sequence(s)
      AK028248
      Consensus CDS
      CCDS26832.1
      UniProtKB/Swiss-Prot
      Q9JI78
      Related
      ENSMUSP00000022310.7, ENSMUST00000022310.7
      Conserved Domains (5) summary
      cd10459
      Location:19109
      PUB_PNGase; PNGase/UBA or UBX (PUB) domain of the P97 adaptor protein Peptide:N-glycanase (PNGase)
      COG1305
      Location:290351
      YebA; Transglutaminase-like enzyme, putative cysteine protease [Posttranslational modification, protein turnover, chaperones]
      pfam01841
      Location:272351
      Transglut_core; Transglutaminase-like superfamily
      pfam03835
      Location:335419
      Rad4; Rad4 transglutaminase-like domain
      pfam04721
      Location:454648
      PAW; PNGase C-terminal domain, mannose-binding module PAW

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000080.7 Reference GRCm39 C57BL/6J

      Range
      6157837..6220449 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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