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    Maea macrophage erythroblast attacher [ Mus musculus (house mouse) ]

    Gene ID: 59003, updated on 2-Oct-2018

    Summary

    Official Symbol
    Maeaprovided by MGI
    Official Full Name
    macrophage erythroblast attacherprovided by MGI
    Primary source
    MGI:MGI:1891748
    See related
    Ensembl:ENSMUSG00000079562 Vega:OTTMUSG00000055361
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    EMP; Gid9; 1110030D19Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 65.7), placenta adult (RPKM 57.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Maea in Genome Data Viewer
    Location:
    5; 5 B1
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 5 NC_000071.6 (33335572..33373294)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 5 NC_000071.5 (33678221..33715943)

    Chromosome 5 - NC_000071.6Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC108167380 Neighboring gene predicted gene 20465 Neighboring gene UV stimulated scaffold protein A Neighboring gene NK1 homeobox 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actin binding ISO
    Inferred from Sequence Orthology
    more info
     
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    cell adhesion ISO
    Inferred from Sequence Orthology
    more info
     
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enucleate erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    erythrocyte maturation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    negative regulation of gluconeogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of myeloid cell apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    GID complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    actomyosin contractile ring ISO
    Inferred from Sequence Orthology
    more info
     
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    integral component of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear matrix ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    spindle ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein transferase MAEA; macrophage erythroblast attacher
    Names
    erythroblast macrophage protein
    NP_067475.2
    XP_006504104.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021500.2NP_067475.2  E3 ubiquitin-protein transferase MAEA

      See identical proteins and their annotated locations for NP_067475.2

      Status: VALIDATED

      Source sequence(s)
      BC058687, CX212584
      Consensus CDS
      CCDS39063.1
      UniProtKB/Swiss-Prot
      Q4VC33
      Related
      ENSMUSP00000110093.3, OTTMUSP00000072240, ENSMUST00000114449.6, OTTMUST00000137068
      Conserved Domains (3) summary
      smart00667
      Location:120153
      LisH; Lissencephaly type-1-like homology motif
      pfam10607
      Location:160301
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd16659
      Location:336383
      RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000071.6 Reference GRCm38.p4 C57BL/6J

      Range
      33335572..33373294
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006504041.1XP_006504104.1  macrophage erythroblast attacher isoform X1

      See identical proteins and their annotated locations for XP_006504104.1

      Conserved Domains (3) summary
      smart00667
      Location:72105
      LisH; Lissencephaly type-1-like homology motif
      pfam10607
      Location:112253
      CLTH; CTLH/CRA C-terminal to LisH motif domain
      cd16659
      Location:288335
      RING-Ubox_Emp; U-box domain, a modified RING finger, found in erythroblast macrophage protein (Emp) and similar proteins
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