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    Nectin3 nectin cell adhesion molecule 3 [ Mus musculus (house mouse) ]

    Gene ID: 58998, updated on 5-Sep-2021

    Summary

    Official Symbol
    Nectin3provided by MGI
    Official Full Name
    nectin cell adhesion molecule 3provided by MGI
    Primary source
    MGI:MGI:1930171
    See related
    Ensembl:ENSMUSG00000022656
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    P; CD113; Pvrl3; necti; AA407785; AU016832; AW538082; 2610301B19Rik; 3000002N23Rik; 4921513D19Rik
    Expression
    Broad expression in testis adult (RPKM 13.1), CNS E11.5 (RPKM 4.7) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Nectin3 in Genome Data Viewer
    Location:
    16; 16 B5
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (46208028..46318898, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (46387665..46498535, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (46395118..46497080, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene adenosylhomocysteinase like Neighboring gene predicted gene, 26297 Neighboring gene predicted gene, 17900 Neighboring gene SCO2 cytochrome c oxidase assembly protein pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cell adhesion molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in adherens junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in apical junction complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in apical junction complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell-cell contact zone IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in hippocampal mossy fiber to CA3 synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in integral component of postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    nectin-3
    Names
    poliovirus receptor-related 3
    poliovirus receptor-related protein 3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021495.4NP_067470.1  nectin-3 isoform alpha

      See identical proteins and their annotated locations for NP_067470.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (alpha) represents the longest transcript and encodes the longest isoform (alpha).
      Source sequence(s)
      AC113113, AK011949, BQ174425, BU701648, BY713810
      Consensus CDS
      CCDS28206.1
      UniProtKB/Swiss-Prot
      Q9JLB9
      Related
      ENSMUSP00000023334.9, ENSMUST00000023334.15
      Conserved Domains (5) summary
      cd05887
      Location:72167
      Ig1_Nectin-3_like; First immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and similar proteins
      cd12087
      Location:402432
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      smart00410
      Location:64166
      IG_like; Immunoglobulin like
      pfam13927
      Location:287342
      Ig_3; Immunoglobulin domain
      cl11960
      Location:170265
      Ig; Immunoglobulin domain
    2. NM_021496.3NP_067471.1  nectin-3 isoform beta

      See identical proteins and their annotated locations for NP_067471.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (beta) differs in the 3' UTR and coding sequence compared to variant alpha. The resulting isoform (beta) is shorter and has a distinct C-terminus compared to isoform alpha.
      Source sequence(s)
      AC113113, AK013863, BY713810, CJ102084
      Consensus CDS
      CCDS28204.1
      UniProtKB/Swiss-Prot
      Q9JLB9
      Related
      ENSMUSP00000023335.7, ENSMUST00000023335.13
      Conserved Domains (4) summary
      cd05887
      Location:72167
      Ig1_Nectin-3_like; First immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and similar proteins
      smart00410
      Location:64166
      IG_like; Immunoglobulin like
      pfam13927
      Location:287342
      Ig_3; Immunoglobulin domain
      cl11960
      Location:170265
      Ig; Immunoglobulin domain
    3. NM_021497.2NP_067472.1  nectin-3 isoform gamma

      See identical proteins and their annotated locations for NP_067472.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (gamma) differs in the 3' UTR and coding sequence compared to variant alpha. The resulting isoform (gamma) is shorter and has a distinct C-terminus compared to isoform alpha.
      Source sequence(s)
      AF195835, BY713810
      Consensus CDS
      CCDS28205.1
      UniProtKB/Swiss-Prot
      Q9JLB9
      Related
      ENSMUSP00000093757.3, ENSMUST00000096052.9
      Conserved Domains (4) summary
      cd05887
      Location:72167
      Ig1_Nectin-3_like; First immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and similar proteins
      smart00410
      Location:64166
      IG_like; Immunoglobulin like
      pfam13927
      Location:287342
      Ig_3; Immunoglobulin domain
      cl11960
      Location:170265
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      46208028..46318898 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006522434.5XP_006522497.1  nectin-3 isoform X1

      Conserved Domains (3) summary
      cd05887
      Location:72167
      Ig1_Nectin-3_like; First immunoglobulin (Ig) domain of nectin-3 (also known as poliovirus receptor related protein 3) and similar proteins
      smart00409
      Location:287348
      IG; Immunoglobulin
      cl11960
      Location:170265
      Ig; Immunoglobulin domain
    2. XM_030249225.1XP_030105085.1  nectin-3 isoform X3

      Conserved Domains (3) summary
      cd12087
      Location:190220
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      cd00096
      Location:18
      Ig; Ig strand D [structural motif]
      cl11960
      Location:153
      Ig; Immunoglobulin domain
    3. XM_030249224.2XP_030105084.1  nectin-3 isoform X3

      Conserved Domains (3) summary
      cd12087
      Location:190220
      TM_EGFR-like; Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases
      cd00096
      Location:18
      Ig; Ig strand D [structural motif]
      cl11960
      Location:153
      Ig; Immunoglobulin domain
    4. XM_036160078.1XP_036015971.1  nectin-3 isoform X2

      Conserved Domains (4) summary
      cd00096
      Location:269275
      Ig; Ig strand A [structural motif]
      cd05887
      Location:58167
      IgV_1_Nectin-3_like; First immunoglobulin variable (IgV) domain of nectin-3 (also known as poliovirus receptor related protein 3), and similar domains
      cd07704
      Location:170265
      IgC1_2_Nectin-3-4_like; Second immunoglobulin (Ig) domain of nectin-3 and nectin-4 (poliovirus receptor related protein 4), and similar domains; member of the C1-set of Ig superfamily (IgSF) domains
      cl11960
      Location:269355
      Ig; Immunoglobulin domain

    RNA

    1. XR_001781847.2 RNA Sequence

    2. XR_001781846.3 RNA Sequence

    3. XR_001781848.3 RNA Sequence

    4. XR_003951810.2 RNA Sequence

    5. XR_003951811.1 RNA Sequence

    6. XR_384583.5 RNA Sequence

    7. XR_003951809.2 RNA Sequence

    8. XR_003951812.1 RNA Sequence

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