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    RAD51 RAD51 recombinase [ Homo sapiens (human) ]

    Gene ID: 5888, updated on 11-Jul-2021

    Summary

    Official Symbol
    RAD51provided by HGNC
    Official Full Name
    RAD51 recombinaseprovided by HGNC
    Primary source
    HGNC:HGNC:9817
    See related
    Ensembl:ENSG00000051180 MIM:179617
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RECA; BRCC5; FANCR; MRMV2; HRAD51; RAD51A; HsRad51; HsT16930
    Summary
    The protein encoded by this gene is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. This protein is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]
    Expression
    Biased expression in testis (RPKM 6.6), bone marrow (RPKM 3.5) and 13 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RAD51 in Genome Data Viewer
    Location:
    15q15.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (40694774..40732340)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (40987372..41024538)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene tRNA-Ser (anticodon GCT) 4-2 Neighboring gene kinetochore scaffold 1 Neighboring gene RNA, 7SL, cytoplasmic 376, pseudogene Neighboring gene RAD51 antisense RNA 1 Neighboring gene regulator of microtubule dynamics 3 Neighboring gene SUMO2 pseudogene 15

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Expression of Rad51 enhances basal- and HIV-1 Tat-induced transcription of the HIV-1 LTR promoter; this event requires cooperativity from the C/EBP family of transcription factors including C/EBPbeta and C/EBPbeta homologous protein (CHOP) PubMed
    tat In PC12 cells treated with genotoxic agents, HIV-1 Tat reduces DNA breakage and increases repair of DNA double-strand breaks through a mechanism involving the upregulation of Rad51, a key regulator of homologous recombination in cells PubMed
    tat HIV-1 Tat interacts with the RNA polymerase II holoenzyme, which includes HRAD51, during Tat-mediated transactivation of the HIV-1 LTR PubMed
    Vpr vpr HIV-1 Vpr inhibits the interaction of p53 and Rad51 in chromatin fractions, as observed under irradiation-induced DNA double-strand breaks PubMed
    vpr HIV-1 Vpr stimulates the focus formation of Rad51 and BRCA1, which are involved in repair of DNA double-strand breaks (DSBs) by homologous recombination (HR) PubMed
    integrase gag-pol K133A RAD51 mutant remains to bind DNA but is unable to form an active nucleofilament due to the poor binding of ATP, which results in the defect on IN inhibition PubMed
    gag-pol RAD51 protein inhibits the integration catalyzed by HIV-1 integrase both in vitro, in yeast expressing integrase and in infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ATPase, acting on DNA IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables DNA polymerase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables DNA strand exchange activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein C-terminus binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables single-stranded DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables single-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables single-stranded DNA helicase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded DNA helicase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA recombinase assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in DNA recombinase assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in DNA recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA repair TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in DNA unwinding involved in DNA replication IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cellular response to camptothecin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to cisplatin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to gamma radiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to hydroxyurea IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to ionizing radiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in chromosome organization involved in meiotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in double-strand break repair via homologous recombination TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in interstrand cross-link repair IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in meiotic cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mitotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in mitotic recombination-dependent replication fork processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA ligation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in reciprocal meiotic recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in regulation of double-strand break repair via homologous recombination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in replication fork processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in replication fork processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in replication-born double-strand break repair via sister chromatid exchange IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to X-ray IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to drug IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to glucoside IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in strand invasion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in telomere maintenance via recombination ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in telomere maintenance via telomere lengthening ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in PML body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in condensed chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in condensed nuclear chromosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in condensed nuclear chromosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lateral element IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in microtubule organizing center IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrial matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear chromosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in site of double-strand break IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    DNA repair protein RAD51 homolog 1
    Names
    BRCA1/BRCA2-containing complex, subunit 5
    RAD51 homolog A
    RecA, E. coli, homolog of
    RecA-like protein
    recombination protein A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012120.1 RefSeqGene

      Range
      5014..42180
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_313

    mRNA and Protein(s)

    1. NM_001164269.2NP_001157741.1  DNA repair protein RAD51 homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_001157741.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR, compared to variant 2. Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC012476, AC022405, AK131299
      Consensus CDS
      CCDS53931.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000372088.3, ENST00000382643.7
      Conserved Domains (3) summary
      cd01123
      Location:116336
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR02239
      Location:25340
      recomb_RAD51; DNA repair protein RAD51
      pfam14520
      Location:3277
      HHH_5; Helix-hairpin-helix domain
    2. NM_001164270.2NP_001157742.1  DNA repair protein RAD51 homolog 1 isoform 3

      See identical proteins and their annotated locations for NP_001157742.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate exon in the 5' coding region and lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 2. The resulting isoform (3) contains a distinct segment near the N-terminus and has a shorter and distinct C-terminus, compared to isoform 2.
      Source sequence(s)
      AC012476, D14134, EU362635
      Consensus CDS
      CCDS53932.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000406602.2, ENST00000423169.6
      Conserved Domains (1) summary
      TIGR02239
      Location:25258
      recomb_RAD51; DNA repair protein RAD51
    3. NM_002875.5NP_002866.2  DNA repair protein RAD51 homolog 1 isoform 1

      See identical proteins and their annotated locations for NP_002866.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) uses an alternate exon in the 5' coding region, compared to variant 2. The resulting isoform (1) contains a distinct segment near the N-terminus, compared to isoform 2.
      Source sequence(s)
      AC012476, AK313503
      Consensus CDS
      CCDS10062.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000267868.3, ENST00000267868.8
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    4. NM_133487.4NP_597994.3  DNA repair protein RAD51 homolog 1 isoform 2

      See identical proteins and their annotated locations for NP_597994.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript and encodes the longest isoform (2). Both variants 2 and 4 encode the same isoform.
      Source sequence(s)
      AC012476, AK291969
      Consensus CDS
      CCDS53931.1
      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000493712.2, ENST00000645673.2
      Conserved Domains (3) summary
      cd01123
      Location:116336
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
      TIGR02239
      Location:25340
      recomb_RAD51; DNA repair protein RAD51
      pfam14520
      Location:3277
      HHH_5; Helix-hairpin-helix domain

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

      Range
      40694774..40732340
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521861.2XP_011520163.1  DNA repair protein RAD51 homolog 1 isoform X2

      See identical proteins and their annotated locations for XP_011520163.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25258
      recomb_RAD51; DNA repair protein RAD51
    2. XM_011521857.2XP_011520159.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011520159.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    3. XM_011521862.3XP_011520164.1  DNA repair protein RAD51 homolog 1 isoform X3

      Conserved Domains (2) summary
      smart00382
      Location:1182
      AAA; ATPases associated with a variety of cellular activities
      cd01123
      Location:1211
      Rad51_DMC1_radA; Rad51_DMC1_radA,B. This group of recombinases includes the eukaryotic proteins RAD51, RAD55/57 and the meiosis-specific protein DMC1, and the archaeal proteins radA and radB. They are closely related to the bacterial RecA group. Rad51 proteins catalyze a ...
    4. XM_011521860.2XP_011520162.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011520162.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    5. XM_006720626.3XP_006720689.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_006720689.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    6. XM_011521858.2XP_011520160.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011520160.1

      UniProtKB/Swiss-Prot
      Q06609
      Related
      ENSP00000433924.2, ENST00000532743.6
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
    7. XM_011521859.2XP_011520161.1  DNA repair protein RAD51 homolog 1 isoform X1

      See identical proteins and their annotated locations for XP_011520161.1

      UniProtKB/Swiss-Prot
      Q06609
      Conserved Domains (1) summary
      TIGR02239
      Location:25339
      recomb_RAD51; DNA repair protein RAD51
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