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    Hibadh 3-hydroxyisobutyrate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 58875, updated on 23-Jun-2021

    Summary

    Official Symbol
    Hibadhprovided by MGI
    Official Full Name
    3-hydroxyisobutyrate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:1889802
    See related
    Ensembl:ENSMUSG00000029776
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI265272; 6430402H10Rik
    Expression
    Broad expression in kidney adult (RPKM 114.2), liver adult (RPKM 95.3) and 26 other tissues See more
    Orthologs
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    Genomic context

    See Hibadh in Genome Data Viewer
    Location:
    6; 6 B3
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (52523215..52617285, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (52546230..52640300, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (52496224..52590294, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene VISTA enhancer mm48 Neighboring gene RIKEN cDNA 1700094M24 gene Neighboring gene predicted gene, 33047 Neighboring gene predicted gene, 24355 Neighboring gene 60S ribosomal protein L24 pseudogene Neighboring gene Tax1 (human T cell leukemia virus type I) binding protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxyisobutyrate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3-hydroxyisobutyrate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within branched-chain amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in valine catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in valine catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    3-hydroxyisobutyrate dehydrogenase, mitochondrial
    NP_663542.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_145567.1NP_663542.1  3-hydroxyisobutyrate dehydrogenase, mitochondrial precursor

      See identical proteins and their annotated locations for NP_663542.1

      Status: PROVISIONAL

      Source sequence(s)
      BC003914
      Consensus CDS
      CCDS20151.1
      UniProtKB/Swiss-Prot
      Q99L13
      Related
      ENSMUSP00000031788.9, ENSMUST00000031788.9
      Conserved Domains (3) summary
      TIGR01692
      Location:43330
      HIBADH; 3-hydroxyisobutyrate dehydrogenase
      pfam03446
      Location:38199
      NAD_binding_2; NAD binding domain of 6-phosphogluconate dehydrogenase
      pfam14833
      Location:202329
      NAD_binding_11; NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      52523215..52617285 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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