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    Trpm7 transient receptor potential cation channel, subfamily M, member 7 [ Mus musculus (house mouse) ]

    Gene ID: 58800, updated on 14-Sep-2021

    Summary

    Official Symbol
    Trpm7provided by MGI
    Official Full Name
    transient receptor potential cation channel, subfamily M, member 7provided by MGI
    Primary source
    MGI:MGI:1929996
    See related
    Ensembl:ENSMUSG00000027365
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Lt; CHA; LTR; TRP; CHAK; CHAK1; Ltpr7; Ltrpc7; LTrpC-7; TRPPLIK; 2310022G15Rik; 4833414K03Rik; 5033407O22Rik
    Expression
    Ubiquitous expression in limb E14.5 (RPKM 10.3), CNS E11.5 (RPKM 10.0) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Trpm7 in Genome Data Viewer
    Location:
    2; 2 F1
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (126633478..126718181, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126791558..126876261, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 2 NC_000068.6 (126617294..126701997, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene polymerase (RNA) II (DNA directed) polypeptide L pseudogene Neighboring gene ubiquitin specific peptidase 8 Neighboring gene ubiquitin specific peptidase 50 Neighboring gene solute carrier family 25 (mitochondrial carrier, phosphate carrier), member 3 pseudogene Neighboring gene signal peptide peptidase like 2A Neighboring gene microRNA 3473g

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables calcium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables calcium channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables cation channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables cation channel activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables ion channel activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables myosin binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within actomyosin structure organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in calcium ion transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within calcium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium ion transport ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within calcium-dependent cell-matrix adhesion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cation transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cation transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular magnesium ion homeostasis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in divalent inorganic cation homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ion transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in memory ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in necroptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within phosphorylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    acts_upstream_of_or_within programmed cell death IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in neuron projection ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in varicosity ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transient receptor potential cation channel subfamily M member 7
    Names
    channel-kinase 1
    long transient receptor potential channel 7
    transient receptor potential M7
    transient receptor potential-phospholipase C-interacting kinase
    transient receptor potential-related protein, ChaK
    NP_001157797.1
    NP_067425.2
    XP_036018328.1
    XP_036018329.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164325.1NP_001157797.1  transient receptor potential cation channel subfamily M member 7 isoform 2

      See identical proteins and their annotated locations for NP_001157797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter isoform (2), compared to isoform 1.
      Source sequence(s)
      AL732330
      Consensus CDS
      CCDS50700.1
      UniProtKB/Swiss-Prot
      Q923J1
      UniProtKB/TrEMBL
      A2AI57
      Related
      ENSMUSP00000028843.6, ENSMUST00000028843.12
      Conserved Domains (3) summary
      smart00811
      Location:15951813
      Alpha_kinase; Alpha-kinase family
      pfam00520
      Location:8791100
      Ion_trans; Ion transport protein
      pfam16519
      Location:11981249
      TRPM_tetra; Tetramerization domain of TRPM
    2. NM_021450.2NP_067425.2  transient receptor potential cation channel subfamily M member 7 isoform 1

      See identical proteins and their annotated locations for NP_067425.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AL732330
      Consensus CDS
      CCDS16689.1
      UniProtKB/Swiss-Prot
      Q923J1
      Related
      ENSMUSP00000099513.4, ENSMUST00000103224.10
      Conserved Domains (3) summary
      smart00811
      Location:15961814
      Alpha_kinase; Alpha-kinase family
      pfam00520
      Location:8791100
      Ion_trans; Ion transport protein
      pfam16519
      Location:11981249
      TRPM_tetra; Tetramerization domain of TRPM

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      126633478..126718181 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162435.1XP_036018328.1  transient receptor potential cation channel subfamily M member 7 isoform X1

      Conserved Domains (4) summary
      TIGR00870
      Location:6631113
      trp; transient-receptor-potential calcium channel protein
      cd16971
      Location:15191757
      Alpha_kinase_ChaK1_TRMP7; Alpha-kinase domain of channel kinase 1, also called transient receptor potential cation channel subfamily M member 7
      pfam16519
      Location:11351188
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:47312
      LSDAT_euk; SLOG in TRPM
    2. XM_036162436.1XP_036018329.1  transient receptor potential cation channel subfamily M member 7 isoform X2

      Conserved Domains (3) summary
      TIGR00870
      Location:7221172
      trp; transient-receptor-potential calcium channel protein
      pfam16519
      Location:11941247
      TRPM_tetra; Tetramerisation domain of TRPM
      pfam18139
      Location:106371
      LSDAT_euk; SLOG in TRPM

    RNA

    1. XR_001783160.3 RNA Sequence

    2. XR_001783159.3 RNA Sequence

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