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    WIZ WIZ zinc finger [ Homo sapiens (human) ]

    Gene ID: 58525, updated on 17-Jun-2024

    Summary

    Official Symbol
    WIZprovided by HGNC
    Official Full Name
    WIZ zinc fingerprovided by HGNC
    Primary source
    HGNC:HGNC:30917
    See related
    Ensembl:ENSG00000011451 MIM:619715; AllianceGenome:HGNC:30917
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF803
    Summary
    Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; histone methyltransferase binding activity; and transcription corepressor binding activity. Involved in positive regulation of nuclear cell cycle DNA replication and protein stabilization. Located in midbody and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis (RPKM 8.9), fat (RPKM 6.6) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See WIZ in Genome Data Viewer
    Location:
    19p13.12
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (15419978..15449956, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (15544969..15574945, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (15530789..15560767, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904643 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14184 Neighboring gene A-kinase anchoring protein 8 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:15489739-15490654 and GRCh37_chr19:15490655-15491569 Neighboring gene A-kinase anchoring protein 8 like Neighboring gene NANOG hESC enhancer GRCh37_chr19:15523607-15524136 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15524849-15525350 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:15525351-15525850 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:15542458-15543056 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10279 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10280 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10281 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14185 Neighboring gene microRNA 1470 Neighboring gene RAS protein activator like 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14186 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14187 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14188 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14189 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14190 Neighboring gene peptidoglycan recognition protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in positive regulation of nuclear cell cycle DNA replication IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein stabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in extracellular exosome HDA PubMed 
    located_in midbody IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein Wiz
    Names
    widely interspaced zinc finger motifs
    widely-interspaced zinc finger-containing protein
    zinc finger protein 803

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001330395.4NP_001317324.2  protein Wiz isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC006128, AC007059
      Consensus CDS
      CCDS82308.2
      UniProtKB/TrEMBL
      A0A669KBG4, B9EGQ5
      Related
      ENSP00000501256.3, ENST00000674089.4
    2. NM_001371589.1NP_001358518.1  protein Wiz isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC006128, AC007059, AC011492
      Consensus CDS
      CCDS92547.1
      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
      UniProtKB/TrEMBL
      A0A669KAV7
      Related
      ENSP00000500993.1, ENST00000673675.1
      Conserved Domains (1) summary
      sd00017
      Location:317337
      ZF_C2H2; C2H2 Zn finger [structural motif]
    3. NM_001371603.5NP_001358532.2  protein Wiz isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC006128, AC007059
      Consensus CDS
      CCDS92545.1
      UniProtKB/TrEMBL
      A0A669KBH9
      Related
      ENSP00000501300.1, ENST00000674001.1
    4. NM_001411129.1NP_001398058.1  protein Wiz isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC006128, AC007059, AC011492
      Consensus CDS
      CCDS92546.1
      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
      UniProtKB/TrEMBL
      A0A2R8YFV2
    5. NM_021241.3NP_067064.2  protein Wiz isoform 1

      See identical proteins and their annotated locations for NP_067064.2

      Status: VALIDATED

      Source sequence(s)
      AC006128, AC011492, AK131404, AL390184, BC007551, BC014220
      Consensus CDS
      CCDS42516.1
      UniProtKB/TrEMBL
      B9EGQ5
      Related
      ENSP00000263381.5, ENST00000263381.12

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      15419978..15449956 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005260011.4XP_005260068.1  protein Wiz isoform X10

      UniProtKB/TrEMBL
      B9EGQ5
    2. XM_047439178.1XP_047295134.1  protein Wiz isoform X7

    3. XM_005260008.4XP_005260065.1  protein Wiz isoform X5

      See identical proteins and their annotated locations for XP_005260065.1

    4. XM_047439181.1XP_047295137.1  protein Wiz isoform X11

      UniProtKB/TrEMBL
      B9EGQ5
    5. XM_047439179.1XP_047295135.1  protein Wiz isoform X8

    6. XM_047439177.1XP_047295133.1  protein Wiz isoform X6

    7. XM_005260007.5XP_005260064.1  protein Wiz isoform X4

      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
      UniProtKB/TrEMBL
      A0A2R8YFV2
      Related
      ENSP00000495441.1, ENST00000643092.1
      Conserved Domains (1) summary
      sd00017
      Location:317337
      ZF_C2H2; C2H2 Zn finger [structural motif]
    8. XM_005260005.5XP_005260062.1  protein Wiz isoform X2

      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
      Conserved Domains (1) summary
      sd00017
      Location:317337
      ZF_C2H2; C2H2 Zn finger [structural motif]
    9. XM_005260006.5XP_005260063.1  protein Wiz isoform X3

      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
      Conserved Domains (1) summary
      sd00017
      Location:317337
      ZF_C2H2; C2H2 Zn finger [structural motif]
    10. XM_047439180.1XP_047295136.1  protein Wiz isoform X10

      UniProtKB/TrEMBL
      B9EGQ5
    11. XM_047439175.1XP_047295131.1  protein Wiz isoform X1

      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
      UniProtKB/TrEMBL
      A0A669KAV7
    12. XM_005260010.4XP_005260067.1  protein Wiz isoform X9

      See identical proteins and their annotated locations for XP_005260067.1

      UniProtKB/TrEMBL
      B9EGQ5, M0QXA7
      Related
      ENSP00000445824.1, ENST00000545156.5
    13. XM_011528163.3XP_011526465.1  protein Wiz isoform X9

      See identical proteins and their annotated locations for XP_011526465.1

      UniProtKB/TrEMBL
      B9EGQ5, M0QXA7
      Related
      ENSP00000469022.1, ENST00000599910.6
      Conserved Domains (1) summary
      COG5411
      Location:132201
      COG5411; Phosphatidylinositol 5-phosphate phosphatase [Signal transduction mechanisms]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      15544969..15574945 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054321654.1XP_054177629.1  protein Wiz isoform X10

      UniProtKB/TrEMBL
      B9EGQ5
    2. XM_054321649.1XP_054177624.1  protein Wiz isoform X7

    3. XM_054321647.1XP_054177622.1  protein Wiz isoform X5

    4. XM_054321655.1XP_054177630.1  protein Wiz isoform X11

      UniProtKB/TrEMBL
      B9EGQ5
    5. XM_054321650.1XP_054177625.1  protein Wiz isoform X8

    6. XM_054321648.1XP_054177623.1  protein Wiz isoform X6

    7. XM_054321646.1XP_054177621.1  protein Wiz isoform X4

      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
      UniProtKB/TrEMBL
      A0A2R8YFV2
    8. XM_054321645.1XP_054177620.1  protein Wiz isoform X3

      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
    9. XM_054321653.1XP_054177628.1  protein Wiz isoform X10

      UniProtKB/TrEMBL
      B9EGQ5
    10. XM_054321644.1XP_054177619.1  protein Wiz isoform X2

      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
    11. XM_054321643.1XP_054177618.1  protein Wiz isoform X1

      UniProtKB/Swiss-Prot
      B3KVH1, B7ZM82, M0QY21, O95785, Q4G0E0, Q6P6B0, Q6ZN24, Q7LDY6, Q7LDZ1, Q96IG5, Q96SQ6, Q9BUR8, Q9NPT1
      UniProtKB/TrEMBL
      A0A669KAV7
    12. XM_054321651.1XP_054177626.1  protein Wiz isoform X9

      UniProtKB/TrEMBL
      B9EGQ5, M0QXA7
    13. XM_054321652.1XP_054177627.1  protein Wiz isoform X9

      UniProtKB/TrEMBL
      B9EGQ5, M0QXA7