Format

Send to:

Choose Destination
    • Showing Current items.

    Rad18 RAD18 E3 ubiquitin protein ligase [ Mus musculus (house mouse) ]

    Gene ID: 58186, updated on 5-Mar-2019

    Summary

    Official Symbol
    Rad18provided by MGI
    Official Full Name
    RAD18 E3 ubiquitin protein ligaseprovided by MGI
    Primary source
    MGI:MGI:1890476
    See related
    Ensembl:ENSMUSG00000030254
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rad18sc; 2810024C04Rik
    Expression
    Broad expression in testis adult (RPKM 6.5), liver E14 (RPKM 4.9) and 19 other tissues See more
    Orthologs

    Genomic context

    See Rad18 in Genome Data Viewer
    Location:
    6; 6 E3
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 6 NC_000072.6 (112619851..112696692, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 6 NC_000072.5 (112569845..112646664, complement)

    Chromosome 6 - NC_000072.6Genomic Context describing neighboring genes Neighboring gene ADP-ribosylation factor GTPase activating protein 2 pseudogene Neighboring gene BRO1 domain and CAAX motif containing pseudogene Neighboring gene predicted gene, 35824 Neighboring gene predicted gene, 26799

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    Y-form DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
     
    single-stranded DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    single-stranded DNA-dependent ATPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    DNA repair IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to DNA damage stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cellular response to DNA damage stimulus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    negative regulation of DNA recombination IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of cell death ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of chromosome segregation ISO
    Inferred from Sequence Orthology
    more info
     
    postreplication repair IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein autoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein monoubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to UV IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    response to UV IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    Rad6-Rad18 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    XY body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    centrosome ISO
    Inferred from Sequence Orthology
    more info
     
    chromatin IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear body ISO
    Inferred from Sequence Orthology
    more info
     
    nuclear inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    replication fork ISO
    Inferred from Sequence Orthology
    more info
     
    site of double-strand break ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RAD18
    Names
    RAD18 homolog
    RING-type E3 ubiquitin transferase RAD18
    mRAD18Sc
    post-replication repair protein RAD18SC
    postreplication repair protein RAD18
    NP_001161202.1
    NP_067360.2
    XP_006506497.1
    XP_006506498.1
    XP_006506499.1
    XP_006506500.1
    XP_017177178.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001167730.1NP_001161202.1  E3 ubiquitin-protein ligase RAD18 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC157095, AK028505, AK030043
      Consensus CDS
      CCDS51870.1
      UniProtKB/TrEMBL
      E9Q392, Q8CDH2, Q8CED3
      Related
      ENSMUSP00000070619.5, ENSMUST00000068487.11
      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13310
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain
    2. NM_021385.2NP_067360.2  E3 ubiquitin-protein ligase RAD18 isoform 2

      See identical proteins and their annotated locations for NP_067360.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks two alternate in-frame exons compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC157095, AK012795
      Consensus CDS
      CCDS39589.1
      UniProtKB/Swiss-Prot
      Q9QXK2
      Related
      ENSMUSP00000076341.4, ENSMUST00000077088.10
      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13363
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000072.6 Reference GRCm38.p4 C57BL/6J

      Range
      112619851..112696692 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006506437.3XP_006506500.1  E3 ubiquitin-protein ligase RAD18 isoform X5

      Related
      ENSMUSP00000108805.1, ENSMUST00000113180.7
      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13310
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain
    2. XM_006506436.3XP_006506499.1  E3 ubiquitin-protein ligase RAD18 isoform X4

      Related
      ENSMUSP00000108807.1, ENSMUST00000113182.7
      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13363
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain
    3. XM_017321689.1XP_017177178.1  E3 ubiquitin-protein ligase RAD18 isoform X2

    4. XM_006506434.3XP_006506497.1  E3 ubiquitin-protein ligase RAD18 isoform X1

      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13310
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain
    5. XM_006506435.3XP_006506498.1  E3 ubiquitin-protein ligase RAD18 isoform X3

      Conserved Domains (4) summary
      smart00734
      Location:201224
      ZnF_Rad18; Rad18-like CCHC zinc finger
      cd00162
      Location:2563
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      TIGR00599
      Location:13310
      rad18; DNA repair protein rad18
      pfam02037
      Location:248282
      SAP; SAP domain
    Support Center