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    Hic2 hypermethylated in cancer 2 [ Mus musculus (house mouse) ]

    Gene ID: 58180, updated on 31-Jan-2019

    Summary

    Official Symbol
    Hic2provided by MGI
    Official Full Name
    hypermethylated in cancer 2provided by MGI
    Primary source
    MGI:MGI:1929869
    See related
    Ensembl:ENSMUSG00000050240
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    HRG22; AA409108; mKIAA1020
    Expression
    Broad expression in placenta adult (RPKM 11.4), CNS E11.5 (RPKM 5.1) and 26 other tissues See more
    Orthologs

    Genomic context

    See Hic2 in Genome Data Viewer
    Location:
    16; 16 A3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 16 NC_000082.6 (17233587..17263430)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 16 NC_000082.5 (17233680..17263523)

    Chromosome 16 - NC_000082.6Genomic Context describing neighboring genes Neighboring gene ubiquitin-conjugating enzyme E2L 3 Neighboring gene RIMS binding protein 3 Neighboring gene transmembrane protein 191C Neighboring gene phosphatidylinositol 4-kinase alpha Neighboring gene serine (or cysteine) peptidase inhibitor, clade D, member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein C-terminus binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    cellular response to DNA damage stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    hypermethylated in cancer 2 protein
    Names
    hic-2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178922.3NP_849253.2  hypermethylated in cancer 2 protein

      See identical proteins and their annotated locations for NP_849253.2

      Status: VALIDATED

      Source sequence(s)
      AK129266, BC050867, BQ954078, BQ965108
      Consensus CDS
      CCDS27999.1
      UniProtKB/Swiss-Prot
      Q9JLZ6
      Related
      ENSMUSP00000087656.5, ENSMUST00000090190.13
      Conserved Domains (6) summary
      smart00225
      Location:47141
      BTB; Broad-Complex, Tramtrack and Bric a brac
      COG5048
      Location:563617
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:539559
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:537559
      zf-C2H2; Zinc finger, C2H2 type
      pfam00651
      Location:40140
      BTB; BTB/POZ domain
      pfam13465
      Location:580604
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000082.6 Reference GRCm38.p4 C57BL/6J

      Range
      17233587..17263430
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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