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    PVR PVR cell adhesion molecule [ Homo sapiens (human) ]

    Gene ID: 5817, updated on 13-Mar-2020

    Summary

    Official Symbol
    PVRprovided by HGNC
    Official Full Name
    PVR cell adhesion moleculeprovided by HGNC
    Primary source
    HGNC:HGNC:9705
    See related
    Ensembl:ENSG00000073008 MIM:173850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PVS; HVED; CD155; NECL5; TAGE4; Necl-5
    Summary
    The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
    Expression
    Ubiquitous expression in adrenal (RPKM 7.2), placenta (RPKM 6.6) and 25 other tissues See more
    Orthologs

    Genomic context

    See PVR in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    109.20200228 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (44643798..44666162)
    105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (45147098..45169429)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CEA cell adhesion molecule 22, pseudogene Neighboring gene immunoglobulin superfamily member 23 Neighboring gene uncharacterized LOC107985305 Neighboring gene microRNA 4531 Neighboring gene CEA cell adhesion molecule 19 Neighboring gene uncharacterized LOC107985306 Neighboring gene Sharpr-MPRA regulatory region 3873

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    NHGRI GWAS Catalog

    Description
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    NHGRI GWA Catalog
    Overrepresentation of glutamate signaling in Alzheimer's disease: network-based pathway enrichment using meta-analysis of genome-wide association studies.
    NHGRI GWA Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef HIV-1 (SF2) Nef downregulates PVR; downregulation is dependent upon the SH3 binding domain in Nef in A3.01 T cells and HeLa TZM-bl cells PubMed
    nef HIV-1 downregulates PVR on cell surface in a Nef-dependent manner. HIV-1 Vpu contributes to the activity of Nef on surface PVR downregulation PubMed
    nef The Nef proteins from HIV-1 M NL4-3, SIVcpz EK505, and SIVgor CP2139 but not from SIVgsn 166, HIV-1 N CK1.62, and P RBF168, are capable of inducing cell surface downregulation of CD155 PubMed
    nef HIV-1 Vpu and Nef are both required to alter the subcellular localization of CD155 in perinuclear compartments and thus interfere with the efficient transport of CD155 to the cell surface PubMed
    nef NK-cell mediated lysis of HIV-1-infected cells via the interaction between DNAM1 and PVR is reduced by HIV-1 Nef PubMed
    Vpr vpr HIV-1 Vpr upregulates PVR expression during HIV-1 infection in CD4+ T-cells PubMed
    vpr HIV-1 Vpr-mediated upregulation of PVR (CD155) requires the interaction of Vpr with the DDB1-Cul4A E3 ligase and induction of ATR-mediated DNA damage repair and G2 arrest PubMed
    Vpu vpu The Vpu proteins from HIV-1 M NL4-3 and SIVgor CP2139 but not from SIVgsn 166, SIVcpz EK505, HIV-1 N CK1.62, and P RBF168, are capable of inducing cell surface downregulation of CD155 PubMed
    vpu HIV-1 Vpu and Nef are both required to alter the subcellular localization of CD155 in perinuclear compartments, and thus interfere with the efficient transport of CD155 to the cell surface PubMed
    vpu The transmembrane domain of HIV-1 Vpu, particularly A10, A14, and A18, is required for cell surface downregulation of CD155, while the CK-2 phosphorylation sites and the second alpha-helix in the cytoplasmic domain are dispensable PubMed
    vpu HIV-1 Vpu contributes to the activity of Nef on surface PVR downregulation PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • FLJ25946

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    cell adhesion molecule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell adhesion molecule binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    protein homodimerization activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    signaling receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    virus receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    focal adhesion HDA PubMed 
    integral component of membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    poliovirus receptor
    Names
    nectin-like protein 5

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008781.2 RefSeqGene

      Range
      5113..27365
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001135768.3NP_001129240.1  poliovirus receptor isoform beta precursor

      See identical proteins and their annotated locations for NP_001129240.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (beta) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
      Source sequence(s)
      AC243964, AK300349
      Consensus CDS
      CCDS46105.1
      UniProtKB/Swiss-Prot
      P15151
      Related
      ENSP00000385344.3, ENST00000403059.8
      Conserved Domains (3) summary
      cd05718
      Location:43142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:34141
      IG_like; Immunoglobulin like
    2. NM_001135769.3NP_001129241.1  poliovirus receptor isoform gamma precursor

      See identical proteins and their annotated locations for NP_001129241.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (gamma) lacks an internal segment including the putative transmembrane domain, compared to isoform alpha, resulting in its secretion into serum and cerebrospinal fluid.
      Source sequence(s)
      AC243964, AK300349
      Consensus CDS
      CCDS46106.1
      UniProtKB/Swiss-Prot
      P15151
      Related
      ENSP00000340870.3, ENST00000344956.8
      Conserved Domains (3) summary
      cd05718
      Location:43142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:34141
      IG_like; Immunoglobulin like
    3. NM_001135770.3NP_001129242.2  poliovirus receptor isoform delta precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) has an alternate 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (delta), also known as H20B, has a shorter and distinct C-terminus, compared to isoform alpha.
      Source sequence(s)
      AC243964, DC400059, M24406
      Consensus CDS
      CCDS46107.1
      UniProtKB/Swiss-Prot
      P15151
      UniProtKB/TrEMBL
      A0A0A0MSA9
      Related
      ENSP00000383907.3, ENST00000406449.8
      Conserved Domains (3) summary
      cd05718
      Location:43142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins
      smart00410
      Location:34141
      IG_like; Immunoglobulin like
    4. NM_006505.5NP_006496.4  poliovirus receptor isoform alpha precursor

      See identical proteins and their annotated locations for NP_006496.4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (alpha), also known as H20A.
      Source sequence(s)
      AC243964, AK290946, AK300349
      Consensus CDS
      CCDS12640.1
      UniProtKB/Swiss-Prot
      P15151
      UniProtKB/TrEMBL
      A0A0C4DG49, A8K4I1
      Related
      ENSP00000402060.2, ENST00000425690.8
      Conserved Domains (2) summary
      cd05718
      Location:43142
      Ig1_PVR_like; First immunoglobulin (Ig) domain of poliovirus receptor (PVR, also known as CD155) and similar proteins
      cd07703
      Location:145240
      Ig2_Nectin-2_like; Second immunoglobulin (Ig) domain of nectin-2 (also known as poliovirus receptor related protein 2 or CD112) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

      Range
      44643798..44666162
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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