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    Cdc42se1 CDC42 small effector 1 [ Mus musculus (house mouse) ]

    Gene ID: 57912, updated on 31-Jan-2019

    Summary

    Official Symbol
    Cdc42se1provided by MGI
    Official Full Name
    CDC42 small effector 1provided by MGI
    Primary source
    MGI:MGI:1889510
    See related
    Ensembl:ENSMUSG00000046722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SCIP1; Spec1; Cdcse1; AW558204; 1300002M12Rik
    Expression
    Ubiquitous expression in spleen adult (RPKM 34.7), thymus adult (RPKM 34.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Cdc42se1 in Genome Data Viewer
    Location:
    3; 3 F2.1
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 3 NC_000069.6 (95228424..95236424)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 3 NC_000069.5 (95032702..95040331)

    Chromosome 3 - NC_000069.6Genomic Context describing neighboring genes Neighboring gene sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6C Neighboring gene GA repeat binding protein, beta 2 Neighboring gene predicted gene, 16740 Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    Rho GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    phagocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of Rho protein signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    regulation of cell shape ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    small GTPase mediated signal transduction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    cell cortex ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CDC42 small effector protein 1
    Names
    small protein effector 1 of Cdc42

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001038708.3NP_001033797.1  CDC42 small effector protein 1

      See identical proteins and their annotated locations for NP_001033797.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK004859, BC060964, CF105339, CJ290563
      Consensus CDS
      CCDS38545.1
      UniProtKB/Swiss-Prot
      Q8BHL7
      Related
      ENSMUSP00000102819.2, ENSMUST00000107201.8
      Conserved Domains (1) summary
      cl00113
      Location:2967
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    2. NM_172395.3NP_765983.1  CDC42 small effector protein 1

      See identical proteins and their annotated locations for NP_765983.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK004859, AV456394, CJ290563
      Consensus CDS
      CCDS38545.1
      UniProtKB/Swiss-Prot
      Q8BHL7
      Related
      ENSMUSP00000052986.5, ENSMUST00000053872.11
      Conserved Domains (1) summary
      cl00113
      Location:2967
      CRIB; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000069.6 Reference GRCm38.p4 C57BL/6J

      Range
      95228424..95236424
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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