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    Angptl4 angiopoietin-like 4 [ Mus musculus (house mouse) ]

    Gene ID: 57875, updated on 8-Dec-2018

    Summary

    Official Symbol
    Angptl4provided by MGI
    Official Full Name
    angiopoietin-like 4provided by MGI
    Primary source
    MGI:MGI:1888999
    See related
    Ensembl:ENSMUSG00000002289
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Arp4; Bk89; Fiaf; Ng27; Pgar; Hfarp; Pgarg; Pp1158
    Expression
    Biased expression in subcutaneous fat pad adult (RPKM 130.4), genital fat pad adult (RPKM 109.0) and 14 other tissues See more
    Orthologs

    Genomic context

    See Angptl4 in Genome Data Viewer
    Location:
    17; 17 B1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 17 NC_000083.6 (33774900..33781575, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 17 NC_000083.5 (33911845..33918520, complement)

    Chromosome 17 - NC_000083.6Genomic Context describing neighboring genes Neighboring gene membrane-associated ring finger (C3HC4) 2 Neighboring gene RAB11B, member RAS oncogene family Neighboring gene KN motif and ankyrin repeat domains 3 Neighboring gene ribosomal protein S28

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enzyme inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    cellular response to starvation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    negative regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of endothelial cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of lipoprotein lipase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    negative regulation of lipoprotein lipase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of lipid metabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    protein homooligomerization ISO
    Inferred from Sequence Orthology
    more info
     
    triglyceride homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular region ISO
    Inferred from Sequence Orthology
    more info
     
    extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    extracellular space ISO
    Inferred from Sequence Orthology
    more info
    PubMed 

    General protein information

    Preferred Names
    angiopoietin-related protein 4
    Names
    425O18-1
    angiopoietin-like protein 4
    fasting-induced adipose factor
    fibrinogen/angiopoietin-related protein
    hepatic fibrinogen/angiopoietin-related protein
    major histocompatibility complex region NG27
    secreted protein Bk89

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020581.2NP_065606.2  angiopoietin-related protein 4 precursor

      See identical proteins and their annotated locations for NP_065606.2

      Status: VALIDATED

      Source sequence(s)
      AK014564, AW495750, BY783212
      Consensus CDS
      CCDS28629.1
      UniProtKB/Swiss-Prot
      Q9Z1P8
      Related
      ENSMUSP00000002360.9, ENSMUST00000002360.15
      Conserved Domains (2) summary
      cd00087
      Location:187404
      FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...
      pfam08702
      Location:104133
      Fib_alpha; Fibrinogen alpha/beta chain family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000083.6 Reference GRCm38.p4 C57BL/6J

      Range
      33774900..33781575 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 129X1/SvJ

    Genomic

    1. NT_039662.3 Reference GRCm38.p4 129X1/SvJ

      Range
      23655..30330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/MrkTac

    Genomic

    1. NT_187027.1 Reference GRCm38.p4 NOD/MrkTac

      Range
      90560..97243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCm38.p4 NOD/ShiLtJ

    Genomic

    1. NT_187004.1 Reference GRCm38.p4 NOD/ShiLtJ

      Range
      90560..97243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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