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    Hacd3 3-hydroxyacyl-CoA dehydratase 3 [ Mus musculus (house mouse) ]

    Gene ID: 57874, updated on 8-Aug-2021

    Summary

    Official Symbol
    Hacd3provided by MGI
    Official Full Name
    3-hydroxyacyl-CoA dehydratase 3provided by MGI
    Primary source
    MGI:MGI:1889341
    See related
    Ensembl:ENSMUSG00000033629
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ptp; B-in; Hcad3; Hspc1; B-ind1; Hspc121; Ptplad1; AW742319; 4930523M17Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 48.9), ovary adult (RPKM 29.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Hacd3 in Genome Data Viewer
    Location:
    9; 9 C
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (64894265..64929014, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (64986983..65021732, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 9 NC_000075.5 (64834790..64869524, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 24 (sodium/potassium/calcium exchanger), member 1 Neighboring gene predicted gene, 39361 Neighboring gene integrator complex subunit 14 Neighboring gene predicted gene, 25640 Neighboring gene predicted gene, 39362 Neighboring gene dipeptidylpeptidase 8 Neighboring gene NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • MGC25483

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 3-hydroxy-arachidoyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3-hydroxy-behenoyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3-hydroxy-lignoceroyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables 3-hydroxyacyl-CoA dehydratase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables 3-hydroxyacyl-CoA dehydratase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables very-long-chain 3-hydroxyacyl-CoA dehydratase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in integral component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3
    Names
    butyrate-induced protein 1
    butyrate-induced transcript 1
    protein tyrosine phosphatase-like A domain containing 1
    protein tyrosine phosphatase-like protein PTPLAD1
    protein-tyrosine phosphatase-like A domain-containing protein 1
    very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 3
    NP_067320.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_021345.2NP_067320.2  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 3

      See identical proteins and their annotated locations for NP_067320.2

      Status: VALIDATED

      Source sequence(s)
      AK159494, CJ176979, CX209453
      Consensus CDS
      CCDS23284.1
      UniProtKB/Swiss-Prot
      Q8K2C9
      Related
      ENSMUSP00000044955.6, ENSMUST00000036615.7
      Conserved Domains (2) summary
      cd06465
      Location:8115
      p23_hB-ind1_like; p23_like domain found in human (h) butyrate-induced transcript 1 (B-ind1) and similar proteins. hB-ind1 participates in signaling by the small GTPase Rac1. It binds to Rac1 and enhances different Rac1 effects including activation of nuclear factor (NF) ...
      pfam04387
      Location:195352
      PTPLA; Protein tyrosine phosphatase-like protein, PTPLA

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      64894265..64929014 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_001778950.2 RNA Sequence

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