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    Bin3 bridging integrator 3 [ Mus musculus (house mouse) ]

    Gene ID: 57784, updated on 31-Jan-2019

    Summary

    Official Symbol
    Bin3provided by MGI
    Official Full Name
    bridging integrator 3provided by MGI
    Primary source
    MGI:MGI:1929883
    See related
    Ensembl:ENSMUSG00000022089
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700015F07Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 5.9), liver E14 (RPKM 5.4) and 28 other tissues See more
    Orthologs

    Genomic context

    See Bin3 in Genome Data Viewer
    Location:
    14; 14 D2
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 14 NC_000080.6 (70100090..70138206)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (70499952..70538013)

    Chromosome 14 - NC_000080.6Genomic Context describing neighboring genes Neighboring gene early growth response 3 Neighboring gene predicted gene, 41199 Neighboring gene cell cycle activator and apoptosis regulator 2 Neighboring gene RIKEN cDNA 9930012K11 gene Neighboring gene PDZ and LIM domain 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    cytoskeletal protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    contributes_to lipid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Process Evidence Code Pubs
    actin cortical patch localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    cell division IEA
    Inferred from Electronic Annotation
    more info
     
    division septum assembly IEA
    Inferred from Electronic Annotation
    more info
     
    endocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    myoblast migration involved in skeletal muscle regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    plasma membrane tubulation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle fiber development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    skeletal muscle tissue regeneration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    unidimensional cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    actin cortical patch IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with actin filament IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001360404.1NP_001347333.1  bridging integrator 3 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151836, AI464318, AK005992, BB682940, CA562064, CX565660
      Conserved Domains (1) summary
      cl12013
      Location:1192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. NM_021328.4NP_067303.1  bridging integrator 3 isoform 1

      See identical proteins and their annotated locations for NP_067303.1

      Status: VALIDATED

      Source sequence(s)
      AC151836, AI464318, AK005992, BB682940, CA562064
      Consensus CDS
      CCDS27247.1
      UniProtKB/Swiss-Prot
      Q9JI08
      Related
      ENSMUSP00000022680.7, ENSMUST00000022680.8
      Conserved Domains (1) summary
      cd07590
      Location:12236
      BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000080.6 Reference GRCm38.p4 C57BL/6J

      Range
      70100090..70138206
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006519331.2XP_006519394.1  bridging integrator 3 isoform X2

      Conserved Domains (1) summary
      cl12013
      Location:1192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    2. XM_006519330.2XP_006519393.1  bridging integrator 3 isoform X1

      Conserved Domains (1) summary
      cd07590
      Location:12209
      BAR_Bin3; The Bin/Amphiphysin/Rvs (BAR) domain of Bridging integrator 3
    3. XM_006519332.3XP_006519395.1  bridging integrator 3 isoform X2

      See identical proteins and their annotated locations for XP_006519395.1

      Conserved Domains (1) summary
      cl12013
      Location:1192
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    4. XM_011245124.2XP_011243426.1  bridging integrator 3 isoform X3

      Conserved Domains (1) summary
      cl12013
      Location:1114
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
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