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    Tacc2 transforming, acidic coiled-coil containing protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 57752, updated on 23-May-2018

    Summary

    Official Symbol
    Tacc2provided by MGI
    Official Full Name
    transforming, acidic coiled-coil containing protein 2provided by MGI
    Primary source
    MGI:MGI:1928899
    See related
    Ensembl:ENSMUSG00000030852 Vega:OTTMUSG00000059551
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mKIAA4180
    Summary
    This gene encodes a member of the transforming, acidic coiled-coil (TACC) family of proteins. Members of this family are centrosomal proteins that interact with microtubules and tubulin. TACC proteins are thought to be involved in centrosome/mitotic spindle dynamics and gene regulation. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in heart adult (RPKM 13.1), bladder adult (RPKM 5.9) and 22 other tissues See more
    Orthologs

    Genomic context

    See Tacc2 in Genome Data Viewer
    Location:
    7; 7 F3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 7 NC_000073.6 (130553009..130767705)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 7 NC_000073.5 (137720998..137908298)

    Chromosome 7 - NC_000073.6Genomic Context describing neighboring genes Neighboring gene arginyltransferase 1 Neighboring gene predicted gene 4275 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component Neighboring gene predicted gene, 34365 Neighboring gene predicted gene, 39098 Neighboring gene predicted gene, 34283 Neighboring gene histone H2A.Z-like Neighboring gene BTB (POZ) domain containing 16 Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 Neighboring gene predicted gene 5602

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA4180

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    nuclear hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    astral microtubule organization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    cell proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    cerebral cortex development IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cerebral cortex development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    interkinetic nuclear migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    microtubule cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of microtubule-based process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    transforming acidic coiled-coil-containing protein 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004468.2NP_001004468.1  transforming acidic coiled-coil-containing protein 2 isoform c

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) encodes the longest protein (isoform c).
      Source sequence(s)
      AC145294, AC175034
      Consensus CDS
      CCDS21903.1
      UniProtKB/TrEMBL
      E9Q8T1
      Related
      ENSMUSP00000081561.4, OTTMUSP00000076124, ENSMUST00000084513.11, OTTMUST00000146110
      Conserved Domains (3) summary
      pfam05010
      Location:26732873
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:27842872
      FadA; Adhesion protein FadA
      cl23765
      Location:26922809
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    2. NM_001347637.1NP_001334566.1  transforming acidic coiled-coil-containing protein 2 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) uses an alternate promoter and lacks two alternate in-frame segments compared to variant 3. These differences cause translation initiation at a downstream start codon and result in an isoform (d) with a shorter N-terminus and lacking two alternate internal segments compared to isoform c.
      Source sequence(s)
      AC145294
      Consensus CDS
      CCDS85432.1
      UniProtKB/Swiss-Prot
      Q9JJG0
    3. NM_021314.4NP_067289.2  transforming acidic coiled-coil-containing protein 2 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents use of an alternate promoter and therefore differs in the 5' UTR and 5' coding region compared to variant 3. These differences cause translation initiation at a downstream start codon and result in an isoform (b) with a shorter N-terminus compared to isoform c.
      Source sequence(s)
      AB041546, AK165194, AK165603, BY732317
      Consensus CDS
      CCDS21905.1
      UniProtKB/Swiss-Prot
      Q9JJG0
      UniProtKB/TrEMBL
      E9QL08
      Related
      ENSMUSP00000033141.6, ENSMUST00000033141.6
      Conserved Domains (3) summary
      pfam05010
      Location:8301030
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:9411029
      FadA; Adhesion protein FadA
      cl11495
      Location:833957
      IncFII_repA; IncFII RepA protein family
    4. NM_206856.3NP_996738.2  transforming acidic coiled-coil-containing protein 2 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon, compared to variant 3, resulting in a shorter protein (isoform a) that has a shorter N-terminus, compared to isoform c.
      Source sequence(s)
      AK145721, AK165194, AY177410, CD561467
      Consensus CDS
      CCDS21904.1
      UniProtKB/Swiss-Prot
      Q9JJG0
      UniProtKB/TrEMBL
      E9Q9Z4, Q3UL40
      Related
      ENSMUSP00000061242.7, ENSMUST00000059145.13
      Conserved Domains (3) summary
      pfam05010
      Location:9401140
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:10511139
      FadA; Adhesion protein FadA
      cl23765
      Location:9591061
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000073.6 Reference GRCm38.p4 C57BL/6J

      Range
      130553009..130767705
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006508065.3XP_006508128.1  transforming acidic coiled-coil-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508128.1

      Conserved Domains (2) summary
      pfam05010
      Location:27192922
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28332921
      FadA; Adhesion protein FadA
    2. XM_017322391.1XP_017177880.1  transforming acidic coiled-coil-containing protein 2 isoform X2

      Conserved Domains (3) summary
      pfam05010
      Location:27192919
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28302918
      FadA; Adhesion protein FadA
      pfam15821
      Location:27552842
      DUF4709; Domain of unknown function (DUF4709)
    3. XM_017322394.1XP_017177883.1  transforming acidic coiled-coil-containing protein 2 isoform X5

      Conserved Domains (2) summary
      pfam05010
      Location:26892892
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28032891
      FadA; Adhesion protein FadA
    4. XM_017322396.1XP_017177885.1  transforming acidic coiled-coil-containing protein 2 isoform X7

    5. XM_017322405.1XP_017177894.1  transforming acidic coiled-coil-containing protein 2 isoform X16

      Conserved Domains (2) summary
      pfam05010
      Location:26422845
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:27562844
      FadA; Adhesion protein FadA
    6. XM_017322406.1XP_017177895.1  transforming acidic coiled-coil-containing protein 2 isoform X17

      Conserved Domains (3) summary
      pfam05010
      Location:26422842
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:27532841
      FadA; Adhesion protein FadA
      cl23765
      Location:26612778
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    7. XM_017322392.1XP_017177881.1  transforming acidic coiled-coil-containing protein 2 isoform X3

      Conserved Domains (2) summary
      pfam05010
      Location:27142917
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28282916
      FadA; Adhesion protein FadA
    8. XM_017322399.1XP_017177888.1  transforming acidic coiled-coil-containing protein 2 isoform X10

    9. XM_017322400.1XP_017177889.1  transforming acidic coiled-coil-containing protein 2 isoform X11

    10. XM_017322407.1XP_017177896.1  transforming acidic coiled-coil-containing protein 2 isoform X18

      Conserved Domains (3) summary
      pfam05010
      Location:26372837
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:27482836
      FadA; Adhesion protein FadA
      cl23765
      Location:26562773
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    11. XM_017322395.1XP_017177884.1  transforming acidic coiled-coil-containing protein 2 isoform X6

      Conserved Domains (2) summary
      pfam05010
      Location:26882891
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28022890
      FadA; Adhesion protein FadA
    12. XM_017322397.1XP_017177886.1  transforming acidic coiled-coil-containing protein 2 isoform X8

      Conserved Domains (3) summary
      pfam05010
      Location:26882888
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:27992887
      FadA; Adhesion protein FadA
      pfam15821
      Location:27242811
      DUF4709; Domain of unknown function (DUF4709)
    13. XM_017322402.1XP_017177891.1  transforming acidic coiled-coil-containing protein 2 isoform X13

    14. XM_017322403.1XP_017177892.1  transforming acidic coiled-coil-containing protein 2 isoform X14

    15. XM_017322408.1XP_017177897.1  transforming acidic coiled-coil-containing protein 2 isoform X19

      Conserved Domains (2) summary
      pfam05010
      Location:26112814
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:27252813
      FadA; Adhesion protein FadA
    16. XM_017322409.1XP_017177898.1  transforming acidic coiled-coil-containing protein 2 isoform X20

      Conserved Domains (3) summary
      pfam05010
      Location:26112811
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:27222810
      FadA; Adhesion protein FadA
      cl23765
      Location:26302747
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    17. XM_017322401.1XP_017177890.1  transforming acidic coiled-coil-containing protein 2 isoform X12

    18. XM_017322410.1XP_017177899.1  transforming acidic coiled-coil-containing protein 2 isoform X21

    19. XM_017322398.1XP_017177887.1  transforming acidic coiled-coil-containing protein 2 isoform X9

    20. XM_017322404.1XP_017177893.1  transforming acidic coiled-coil-containing protein 2 isoform X15

      Conserved Domains (3) summary
      pfam05010
      Location:26542854
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:27652853
      FadA; Adhesion protein FadA
      cl23765
      Location:26732790
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    21. XM_017322411.1XP_017177900.1  transforming acidic coiled-coil-containing protein 2 isoform X22

      Conserved Domains (2) summary
      pfam05010
      Location:9781181
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:10921180
      FadA; Adhesion protein FadA
    22. XM_017322412.1XP_017177901.1  transforming acidic coiled-coil-containing protein 2 isoform X23

      Conserved Domains (3) summary
      pfam05010
      Location:9471147
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:10581146
      FadA; Adhesion protein FadA
      cl23765
      Location:9661068
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    23. XM_017322413.1XP_017177902.1  transforming acidic coiled-coil-containing protein 2 isoform X24

      Conserved Domains (2) summary
      pfam05010
      Location:9361139
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:10501138
      FadA; Adhesion protein FadA
    24. XM_017322393.1XP_017177882.1  transforming acidic coiled-coil-containing protein 2 isoform X4

      Conserved Domains (2) summary
      pfam05010
      Location:27002903
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28142902
      FadA; Adhesion protein FadA
    25. XM_006508067.3XP_006508130.1  transforming acidic coiled-coil-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508130.1

      Conserved Domains (2) summary
      pfam05010
      Location:27192922
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28332921
      FadA; Adhesion protein FadA
    26. XM_006508066.3XP_006508129.1  transforming acidic coiled-coil-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508129.1

      Conserved Domains (2) summary
      pfam05010
      Location:27192922
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28332921
      FadA; Adhesion protein FadA
    27. XM_017322390.1XP_017177879.1  transforming acidic coiled-coil-containing protein 2 isoform X1

      Conserved Domains (2) summary
      pfam05010
      Location:27192922
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28332921
      FadA; Adhesion protein FadA
    28. XM_006508064.3XP_006508127.1  transforming acidic coiled-coil-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_006508127.1

      Conserved Domains (2) summary
      pfam05010
      Location:27192922
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:28332921
      FadA; Adhesion protein FadA
    29. XM_011241876.2XP_011240178.1  transforming acidic coiled-coil-containing protein 2 isoform X26

      See identical proteins and their annotated locations for XP_011240178.1

      Conserved Domains (1) summary
      pfam05010
      Location:474677
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    30. XM_017322415.1XP_017177904.1  transforming acidic coiled-coil-containing protein 2 isoform X32

    31. XM_011241872.2XP_011240174.1  transforming acidic coiled-coil-containing protein 2 isoform X26

      See identical proteins and their annotated locations for XP_011240174.1

      Conserved Domains (1) summary
      pfam05010
      Location:474677
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    32. XM_011241873.2XP_011240175.1  transforming acidic coiled-coil-containing protein 2 isoform X26

      See identical proteins and their annotated locations for XP_011240175.1

      Conserved Domains (1) summary
      pfam05010
      Location:474677
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    33. XM_011241875.2XP_011240177.1  transforming acidic coiled-coil-containing protein 2 isoform X26

      See identical proteins and their annotated locations for XP_011240177.1

      Related
      ENSMUSP00000147054.1, OTTMUSP00000076154, ENSMUST00000207376.1, OTTMUST00000146215
      Conserved Domains (1) summary
      pfam05010
      Location:474677
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
    34. XM_017322414.1XP_017177903.1  transforming acidic coiled-coil-containing protein 2 isoform X31

      Related
      ENSMUSP00000146840.1, OTTMUSP00000076151, ENSMUST00000207549.1, OTTMUST00000146210
    35. XM_006508087.3XP_006508150.1  transforming acidic coiled-coil-containing protein 2 isoform X25

      Conserved Domains (2) summary
      pfam05010
      Location:8491052
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:9631051
      FadA; Adhesion protein FadA
    36. XM_011241874.2XP_011240176.1  transforming acidic coiled-coil-containing protein 2 isoform X33

      Conserved Domains (3) summary
      pfam05010
      Location:8001000
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:911999
      FadA; Adhesion protein FadA
      cl23765
      Location:819921
      iSH2_PI3K_IA_R; Inter-Src homology 2 (iSH2) helical domain of Class IA Phosphoinositide 3-kinase Regulatory subunits
    37. XM_006508088.3XP_006508151.1  transforming acidic coiled-coil-containing protein 2 isoform X27

      Conserved Domains (3) summary
      pfam05010
      Location:8181018
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:9291017
      FadA; Adhesion protein FadA
      cl11495
      Location:821945
      IncFII_repA; IncFII RepA protein family
    38. XM_006508089.3XP_006508152.1  transforming acidic coiled-coil-containing protein 2 isoform X28

      Conserved Domains (2) summary
      pfam05010
      Location:788991
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:902990
      FadA; Adhesion protein FadA
    39. XM_006508090.3XP_006508153.1  transforming acidic coiled-coil-containing protein 2 isoform X29

      Conserved Domains (3) summary
      pfam05010
      Location:788988
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:899987
      FadA; Adhesion protein FadA
      cl11495
      Location:791915
      IncFII_repA; IncFII RepA protein family
    40. XM_006508091.3XP_006508154.1  transforming acidic coiled-coil-containing protein 2 isoform X30

      Related
      ENSMUSP00000146848.1, OTTMUSP00000076112, ENSMUST00000207282.1, OTTMUST00000146067
      Conserved Domains (3) summary
      pfam05010
      Location:741941
      TACC; Transforming acidic coiled-coil-containing protein (TACC)
      pfam09403
      Location:852940
      FadA; Adhesion protein FadA
      cl11495
      Location:744868
      IncFII_repA; IncFII RepA protein family
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