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    Rnf25 ring finger protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 57751, updated on 5-Aug-2018

    Summary

    Official Symbol
    Rnf25provided by MGI
    Official Full Name
    ring finger protein 25provided by MGI
    Primary source
    MGI:MGI:1890215
    See related
    Ensembl:ENSMUSG00000026171 Vega:OTTMUSG00000021746
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AO7; 0610009H16Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 37.6), limb E14.5 (RPKM 24.8) and 28 other tissues See more
    Orthologs

    Genomic context

    See Rnf25 in Genome Data Viewer
    Location:
    1; 1 C3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (74593748..74601397, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74640326..74647971, complement)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene zinc finger protein 142 Neighboring gene BCS1-like (yeast) Neighboring gene serine/threonine kinase 36 Neighboring gene tubulin tyrosine ligase-like family, member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from BioSystems

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF25
    Names
    RING finger protein AO7
    RING-type E3 ubiquitin transferase RNF25
    NP_001292159.1
    NP_067288.2
    XP_006496233.1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305230.1NP_001292159.1  E3 ubiquitin-protein ligase RNF25 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant (1). The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC117610, AK002399, AK011171, BG081026, BP774070
      Consensus CDS
      CCDS78620.1
      UniProtKB/Swiss-Prot
      Q9QZR0
      UniProtKB/TrEMBL
      E9Q446, Q9CT51
      Related
      ENSMUSP00000109350.1, OTTMUSP00000024324, ENSMUST00000113721.7, OTTMUST00000051606
      Conserved Domains (2) summary
      smart00591
      Location:19127
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam13639
      Location:132198
      zf-RING_2; Ring finger domain
    2. NM_021313.3NP_067288.2  E3 ubiquitin-protein ligase RNF25 isoform 1

      See identical proteins and their annotated locations for NP_067288.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC117610, AK002399, BE853767, BP774070
      Consensus CDS
      CCDS15052.1
      UniProtKB/Swiss-Prot
      Q9QZR0
      Related
      ENSMUSP00000027357.5, OTTMUSP00000024323, ENSMUST00000027357.11, OTTMUST00000051604
      Conserved Domains (2) summary
      smart00591
      Location:19127
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam13639
      Location:132199
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      74593748..74601397 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496170.1XP_006496233.1  E3 ubiquitin-protein ligase RNF25 isoform X1

      Conserved Domains (2) summary
      smart00591
      Location:694
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam13639
      Location:99166
      zf-RING_2; Ring finger domain
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