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    Rnf25 ring finger protein 25 [ Mus musculus (house mouse) ]

    Gene ID: 57751, updated on 23-Jun-2021

    Summary

    Official Symbol
    Rnf25provided by MGI
    Official Full Name
    ring finger protein 25provided by MGI
    Primary source
    MGI:MGI:1890215
    See related
    Ensembl:ENSMUSG00000026171
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A; AO7; 0610009H16Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 37.6), limb E14.5 (RPKM 24.8) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Rnf25 in Genome Data Viewer
    Location:
    1; 1 C4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (74632907..74640556, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (74593748..74601397, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (74640326..74647971, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 142 Neighboring gene BCS1-like (yeast) Neighboring gene serine/threonine kinase 36 Neighboring gene tubulin tyrosine ligase-like family, member 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables NF-kappaB binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in positive regulation of NF-kappaB transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RNF25
    Names
    RING finger protein AO7
    RING-type E3 ubiquitin transferase RNF25
    NP_001292159.1
    NP_067288.2
    XP_006496233.1
    XP_030111555.1
    XP_036008396.1
    XP_036008397.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305230.1NP_001292159.1  E3 ubiquitin-protein ligase RNF25 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region compared to variant (1). The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC117610, AK002399, AK011171, BG081026, BP774070
      Consensus CDS
      CCDS78620.1
      UniProtKB/Swiss-Prot
      Q9QZR0
      UniProtKB/TrEMBL
      E9Q446, Q9CT51
      Related
      ENSMUSP00000109350.2, ENSMUST00000113721.8
      Conserved Domains (2) summary
      smart00591
      Location:19127
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam13639
      Location:132198
      zf-RING_2; Ring finger domain
    2. NM_021313.3NP_067288.2  E3 ubiquitin-protein ligase RNF25 isoform 1

      See identical proteins and their annotated locations for NP_067288.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC117610, AK002399, BE853767, BP774070
      Consensus CDS
      CCDS15052.1
      UniProtKB/Swiss-Prot
      Q9QZR0
      Related
      ENSMUSP00000027357.6, ENSMUST00000027357.12
      Conserved Domains (2) summary
      smart00591
      Location:19127
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      pfam13639
      Location:132199
      zf-RING_2; Ring finger domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      74632907..74640556 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152504.1XP_036008397.1  E3 ubiquitin-protein ligase RNF25 isoform X4

      Conserved Domains (1) summary
      cd16470
      Location:2288
      RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
    2. XM_036152503.1XP_036008396.1  E3 ubiquitin-protein ligase RNF25 isoform X3

      Conserved Domains (1) summary
      cd16470
      Location:2289
      RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
    3. XM_030255695.2XP_030111555.1  E3 ubiquitin-protein ligase RNF25 isoform X2

      Conserved Domains (2) summary
      smart00591
      Location:694
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      cd16470
      Location:100166
      RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
    4. XM_006496170.3XP_006496233.1  E3 ubiquitin-protein ligase RNF25 isoform X1

      Conserved Domains (2) summary
      smart00591
      Location:694
      RWD; domain in RING finger and WD repeat containing proteins and DEXDc-like helicases subfamily related to the UBCc domain
      cd16470
      Location:100167
      RING-H2_RNF25; RING finger, H2 subclass, found in RING finger protein 25 (RNF25) and similar proteins
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