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    PTPN3 protein tyrosine phosphatase non-receptor type 3 [ Homo sapiens (human) ]

    Gene ID: 5774, updated on 8-Jul-2021

    Summary

    Official Symbol
    PTPN3provided by HGNC
    Official Full Name
    protein tyrosine phosphatase non-receptor type 3provided by HGNC
    Primary source
    HGNC:HGNC:9655
    See related
    Ensembl:ENSG00000070159 MIM:176877
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PTPH1; PTP-H1
    Summary
    The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This protein contains a C-terminal PTP domain and an N-terminal domain homologous to the band 4.1 superfamily of cytoskeletal-associated proteins. P97, a cell cycle regulator involved in a variety of membrane related functions, has been shown to be a substrate of this PTP. This PTP was also found to interact with, and be regulated by adaptor protein 14-3-3 beta. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]
    Expression
    Broad expression in skin (RPKM 9.4), kidney (RPKM 7.8) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PTPN3 in Genome Data Viewer
    Location:
    9q31.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (109375694..109538395, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (112137974..112260587, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene erythrocyte membrane protein band 4.1 like 4B Neighboring gene uncharacterized LOC107987113 Neighboring gene MT-ND2 pseudogene 11 Neighboring gene HNF1 motif-containing MPRA enhancer 98 Neighboring gene microRNA 3927 Neighboring gene Y-box binding protein 1 pseudogene 6 Neighboring gene PALM2 and AKAP2 fusion Neighboring gene putative uncharacterized protein DDB_G0287265 Neighboring gene ribosomal protein L21 pseudogene 87

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • DKFZp686N0569

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytoskeletal protein binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables protein tyrosine phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein tyrosine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    enables sodium channel regulator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytoplasmic side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    tyrosine-protein phosphatase non-receptor type 3
    Names
    cytoskeletal-associated protein tyrosine phosphatase
    protein-tyrosine phosphatase H1
    NP_001138840.1
    NP_001138841.1
    NP_001138842.1
    NP_001138843.1
    NP_001138844.1
    NP_002820.3
    XP_006717260.1
    XP_006717262.1
    XP_006717264.1
    XP_006717265.1
    XP_006717266.1
    XP_006717267.1
    XP_011517190.1
    XP_011517191.1
    XP_016870444.1
    XP_016870445.1
    XP_016870446.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047071.1 RefSeqGene

      Range
      45047..167654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001145368.2NP_001138840.1  tyrosine-protein phosphatase non-receptor type 3 isoform 2

      See identical proteins and their annotated locations for NP_001138840.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) is missing an in-frame coding exon compared to transcript variant 1, resulting in a shorter isoform (2) lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK096975, AK316066, AL359963, BC033716, BC126117, DB173093
      UniProtKB/Swiss-Prot
      P26045
      UniProtKB/TrEMBL
      B7Z9V1, Q8N4S3
      Conserved Domains (7) summary
      smart00194
      Location:604855
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00047
      Location:627854
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:463550
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:115222
      FERM_M; FERM central domain
      pfam09379
      Location:3396
      FERM_N; FERM N-terminal domain
    2. NM_001145369.2NP_001138841.1  tyrosine-protein phosphatase non-receptor type 3 isoform 3

      See identical proteins and their annotated locations for NP_001138841.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, and initiates translation from an in-frame downstream AUG, resulting in an isoform (3) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK096975, AL162733, AL359963, BX648253, BX648735, DB173093, DB306298
      Consensus CDS
      CCDS48001.1
      UniProtKB/Swiss-Prot
      P26045
      Related
      ENSP00000416654.1, ENST00000412145.5
      Conserved Domains (6) summary
      smart00194
      Location:518769
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:291
      B41; Band 4.1 homologues
      cd00047
      Location:541768
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:377464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:85178
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:291
      FERM_M; FERM central domain
    3. NM_001145370.2NP_001138842.1  tyrosine-protein phosphatase non-receptor type 3 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (4) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK096975, AL162733, AL359963, BX648253, BX648735, DB173093, DB306298
      Consensus CDS
      CCDS48000.1
      UniProtKB/Swiss-Prot
      P26045
      Related
      ENSP00000395384.1, ENST00000446349.5
      Conserved Domains (6) summary
      smart00194
      Location:473724
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:291
      B41; Band 4.1 homologues
      cd00047
      Location:496723
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:332419
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:85178
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:291
      FERM_M; FERM central domain
    4. NM_001145371.2NP_001138843.1  tyrosine-protein phosphatase non-receptor type 3 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, and initiates translation from an in-frame downstream AUG, resulting in an isoform (5) with a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AK096975, AK296388, AL359963, BC033716, BC126117, DB173093, DC342461
      UniProtKB/Swiss-Prot
      P26045
      UniProtKB/TrEMBL
      B7Z3V3, Q8N4S3
      Conserved Domains (4) summary
      smart00194
      Location:362613
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:385612
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:221308
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:122
      PH-like; Pleckstrin homology-like domain
    5. NM_001145372.2NP_001138844.1  tyrosine-protein phosphatase non-receptor type 3 isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR, and is missing an in-frame coding exon compared to transcript variant 1, resulting in an isoform (6) with a shorter N-terminus and lacking an internal protein segment compared to isoform 1.
      Source sequence(s)
      AK096975, AK316118, AL359963, BC033716, DB173093, DC342461
      UniProtKB/TrEMBL
      B7ZA03, Q8N4S3
      Conserved Domains (4) summary
      smart00194
      Location:317568
      PTPc; Protein tyrosine phosphatase, catalytic domain
      cd00047
      Location:340567
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:176263
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cl17171
      Location:122
      PH-like; Pleckstrin homology-like domain
    6. NM_002829.4NP_002820.3  tyrosine-protein phosphatase non-receptor type 3 isoform 1

      See identical proteins and their annotated locations for NP_002820.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AK096975, AK316066, AL359963, BC033716, BC126117, DB173093
      Consensus CDS
      CCDS6776.1
      UniProtKB/Swiss-Prot
      P26045
      UniProtKB/TrEMBL
      B7Z9V1, Q8N4S3
      Related
      ENSP00000363667.1, ENST00000374541.4
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00047
      Location:672899
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:508595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)

    RNA

    1. NR_026918.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains an alternate 5' terminal exon, compared to variant 1. This variant is represented as non-coding due to the presence of an upstream ORF that is predicted to interfere with translation of the longest ORF; translation of the upstream ORF renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AK096975, AK303608, AL359963, BC033716, BU624870, DB173093

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

      Range
      109375694..109538395 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011518888.2XP_011517190.1  tyrosine-protein phosphatase non-receptor type 3 isoform X1

      Conserved Domains (7) summary
      smart00194
      Location:670921
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:52243
      B41; Band 4.1 homologues
      cd00047
      Location:693920
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:529616
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:237330
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:136243
      FERM_M; FERM central domain
      pfam09379
      Location:54117
      FERM_N; FERM N-terminal domain
    2. XM_011518889.2XP_011517191.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

      See identical proteins and their annotated locations for XP_011517191.1

      UniProtKB/Swiss-Prot
      P26045
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00047
      Location:672899
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:508595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    3. XM_017014956.1XP_016870445.1  tyrosine-protein phosphatase non-receptor type 3 isoform X7

    4. XM_006717201.3XP_006717264.1  tyrosine-protein phosphatase non-receptor type 3 isoform X4

      Conserved Domains (6) summary
      smart00194
      Location:540791
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:9113
      B41; Band 4.1 homologues
      cd00047
      Location:563790
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:399486
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:107200
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:9113
      FERM_M; FERM central domain
    5. XM_017014957.1XP_016870446.1  tyrosine-protein phosphatase non-receptor type 3 isoform X8

      UniProtKB/Swiss-Prot
      P26045
      Conserved Domains (6) summary
      smart00194
      Location:473724
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:291
      B41; Band 4.1 homologues
      cd00047
      Location:496723
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:332419
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:85178
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:291
      FERM_M; FERM central domain
    6. XM_006717204.3XP_006717267.1  tyrosine-protein phosphatase non-receptor type 3 isoform X6

      See identical proteins and their annotated locations for XP_006717267.1

      UniProtKB/Swiss-Prot
      P26045
      Conserved Domains (6) summary
      smart00194
      Location:518769
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:291
      B41; Band 4.1 homologues
      cd00047
      Location:541768
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:377464
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:85178
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:291
      FERM_M; FERM central domain
    7. XM_006717199.3XP_006717262.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

      See identical proteins and their annotated locations for XP_006717262.1

      UniProtKB/Swiss-Prot
      P26045
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00047
      Location:672899
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:508595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    8. XM_017014955.1XP_016870444.1  tyrosine-protein phosphatase non-receptor type 3 isoform X3

      UniProtKB/Swiss-Prot
      P26045
      Conserved Domains (4) summary
      smart00295
      Location:31222
      B41; Band 4.1 homologues
      cd00047
      Location:672899
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:508595
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:216309
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
    9. XM_006717197.3XP_006717260.1  tyrosine-protein phosphatase non-receptor type 3 isoform X2

      Conserved Domains (7) summary
      smart00194
      Location:660911
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:42233
      B41; Band 4.1 homologues
      cd00047
      Location:683910
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:519606
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:227320
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:126233
      FERM_M; FERM central domain
      pfam09379
      Location:44107
      FERM_N; FERM N-terminal domain
    10. XM_006717202.3XP_006717265.1  tyrosine-protein phosphatase non-receptor type 3 isoform X5

      See identical proteins and their annotated locations for XP_006717265.1

      Conserved Domains (6) summary
      smart00194
      Location:534785
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:6107
      B41; Band 4.1 homologues
      cd00047
      Location:557784
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:393480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:101194
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:8107
      FERM_M; FERM central domain
    11. XM_006717203.4XP_006717266.1  tyrosine-protein phosphatase non-receptor type 3 isoform X5

      See identical proteins and their annotated locations for XP_006717266.1

      Conserved Domains (6) summary
      smart00194
      Location:534785
      PTPc; Protein tyrosine phosphatase, catalytic domain
      smart00295
      Location:6107
      B41; Band 4.1 homologues
      cd00047
      Location:557784
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
      cd00992
      Location:393480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      cd13189
      Location:101194
      FERM_C_PTPN4_PTPN3_like; FERM domain C-lobe of Protein tyrosine phosphatase non-receptor proteins 3 and 4 (PTPN4 and PTPN3)
      pfam00373
      Location:8107
      FERM_M; FERM central domain
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