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    CIP2A cellular inhibitor of PP2A [ Homo sapiens (human) ]

    Gene ID: 57650, updated on 11-Apr-2024

    Summary

    Official Symbol
    CIP2Aprovided by HGNC
    Official Full Name
    cellular inhibitor of PP2Aprovided by HGNC
    Primary source
    HGNC:HGNC:29302
    See related
    Ensembl:ENSG00000163507 MIM:610643; AllianceGenome:HGNC:29302
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    p90; NOCIVA; KIAA1524
    Summary
    Enables protein homodimerization activity. Predicted to act upstream of or within positive regulation of neural precursor cell proliferation and spermatogenesis. Located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 2.5), lymph node (RPKM 2.3) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CIP2A in Genome Data Viewer
    Location:
    3q13.13
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (108549864..108589438, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (111258902..111309711, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (108268711..108308285, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene myosin heavy chain 15 Neighboring gene uncharacterized LOC124909406 Neighboring gene ribosomal protein L13 pseudogene 8 Neighboring gene small nucleolar RNA SNORA70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20222 Neighboring gene DAZ interacting zinc finger protein 3 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:108396720-108396891 Neighboring gene uncharacterized LOC105374033

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein CIP2A
    Names
    cancerous inhibitor of PP2A
    cancerous inhibitor of protein phosphatase 2A
    cell proliferation regulating inhibitor of protein phosphatase 2A
    p90 autoantigen

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020890.3NP_065941.2  protein CIP2A

      See identical proteins and their annotated locations for NP_065941.2

      Status: VALIDATED

      Source sequence(s)
      AC069499, AK310446, BC017659, BC130564
      Consensus CDS
      CCDS33812.1
      UniProtKB/Swiss-Prot
      A1L4J7, B9EGC3, Q6P4G6, Q8TCG1, Q8WVP8, Q96PI2, Q9H9C6, Q9P204
      Related
      ENSP00000295746.7, ENST00000295746.13
      Conserved Domains (1) summary
      cl25732
      Location:618868
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      108549864..108589438 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006713716.4XP_006713779.1  protein CIP2A isoform X1

      Conserved Domains (3) summary
      pfam15272
      Location:727867
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17045
      Location:632877
      CEP63; Centrosomal protein of 63 kDa
      cl23720
      Location:805890
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. XM_011513057.3XP_011511359.1  protein CIP2A isoform X2

      Conserved Domains (2) summary
      pfam15272
      Location:414554
      BBP1_C; Spindle pole body component BBP1, C-terminal
      pfam17045
      Location:319564
      CEP63; Centrosomal protein of 63 kDa

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      111258902..111309711 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347406.1XP_054203381.1  protein CIP2A isoform X3

      UniProtKB/Swiss-Prot
      A1L4J7, B9EGC3, Q6P4G6, Q8TCG1, Q8WVP8, Q96PI2, Q9H9C6, Q9P204
    2. XM_054347407.1XP_054203382.1  protein CIP2A isoform X1

    3. XM_054347408.1XP_054203383.1  protein CIP2A isoform X2