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    FNIP2 folliculin interacting protein 2 [ Homo sapiens (human) ]

    Gene ID: 57600, updated on 23-Nov-2023

    Summary

    Official Symbol
    FNIP2provided by HGNC
    Official Full Name
    folliculin interacting protein 2provided by HGNC
    Primary source
    HGNC:HGNC:29280
    See related
    Ensembl:ENSG00000052795 MIM:612768; AllianceGenome:HGNC:29280
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FNIPL; MAPO1
    Summary
    This gene encodes a protein that binds to the tumor suppressor folliculin and to AMP-activated protein kinase (AMPK), and may play a role cellular metabolism and nutrient sensing by regulating the AMPK-mechanistic target of rapamycin signaling pathway. The encoded protein may also be involved in regulating the O6-methylguanine-induced apoptosis signaling pathway. This gene has a closely related paralog that encodes a protein with similar binding activities. Both related proteins also associate with the molecular chaperone heat shock protein-90 (Hsp90) and negatively regulate its ATPase activity and facilitate its association with folliculin. [provided by RefSeq, Jul 2017]
    Expression
    Ubiquitous expression in kidney (RPKM 11.0), fat (RPKM 8.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FNIP2 in Genome Data Viewer
    Location:
    4q32.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (158769026..158908050)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (162119774..162258820)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (159690178..159829202)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA U3 Neighboring gene electron transfer flavoprotein dehydrogenase Neighboring gene hESC enhancers GRCh37_chr4:159643958-159644541 and GRCh37_chr4:159644542-159645126 Neighboring gene peptidylprolyl isomerase D Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15773 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:159690086-159690823 Neighboring gene Sharpr-MPRA regulatory region 12747 Neighboring gene RNA, U6 small nuclear 128, pseudogene Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr4:159766516-159767164 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159802306-159803286 Neighboring gene Sharpr-MPRA regulatory region 14183 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159823055-159823920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr4:159823921-159824786 Neighboring gene uncharacterized LOC124900178 Neighboring gene sperm microtubule inner protein 2 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr4:159917411-159918610 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr4:159927373-159927905 Neighboring gene proteasome activator subunit 2 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA1450

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATPase inhibitor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ATPase inhibitor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein-folding chaperone binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of FNIP-folliculin RagC/D GAP IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centriolar satellite IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    folliculin-interacting protein 2
    Names
    FNIP1-like protein
    O6-methylguanine-induced apoptosis 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001323916.2NP_001310845.1  folliculin-interacting protein 2 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AB040883, AC093700, AC107219, BC016638
      UniProtKB/Swiss-Prot
      Q9P278
      Conserved Domains (3) summary
      pfam14636
      Location:69187
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:320553
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9501133
      FNIP_C; Folliculin-interacting protein C-terminus
    2. NM_001346043.2NP_001332972.1  folliculin-interacting protein 2 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AB040883, AC093700, BM806956, HY049314
      UniProtKB/Swiss-Prot
      Q9P278
    3. NM_001366843.1NP_001353772.1  folliculin-interacting protein 2 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC093700, AC107219, AC109823
      Conserved Domains (3) summary
      pfam14636
      Location:69187
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:350583
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9801163
      FNIP_C; Folliculin-interacting protein C-terminus
    4. NM_020840.3NP_065891.1  folliculin-interacting protein 2 isoform 1

      See identical proteins and their annotated locations for NP_065891.1

      Status: REVIEWED

      Source sequence(s)
      AB040883, AC093700, HY049314
      Consensus CDS
      CCDS47155.1
      UniProtKB/Swiss-Prot
      Q05DC3, Q96I31, Q9H994, Q9P278
      Related
      ENSP00000264433.6, ENST00000264433.11
      Conserved Domains (3) summary
      pfam14636
      Location:46164
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:297530
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9271110
      FNIP_C; Folliculin-interacting protein C-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      158769026..158908050
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005263158.3XP_005263215.1  folliculin-interacting protein 2 isoform X2

      Conserved Domains (3) summary
      pfam14636
      Location:46164
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:327560
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9571140
      FNIP_C; Folliculin-interacting protein C-terminus
    2. XM_047416018.1XP_047271974.1  folliculin-interacting protein 2 isoform X5

    3. XM_017008487.2XP_016863976.1  folliculin-interacting protein 2 isoform X1

    4. XM_047416017.1XP_047271973.1  folliculin-interacting protein 2 isoform X4

    5. XM_024454161.2XP_024309929.1  folliculin-interacting protein 2 isoform X6

      Conserved Domains (3) summary
      pfam14636
      Location:69187
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:350583
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9801036
      FNIP_C; Folliculin-interacting protein C-terminus
    6. XM_047416021.1XP_047271977.1  folliculin-interacting protein 2 isoform X8

    7. XM_005263160.4XP_005263217.1  folliculin-interacting protein 2 isoform X3

      Conserved Domains (3) summary
      pfam14636
      Location:69187
      FNIP_N; Folliculin-interacting protein N-terminus
      pfam14637
      Location:350583
      FNIP_M; Folliculin-interacting protein middle domain
      pfam14638
      Location:9801036
      FNIP_C; Folliculin-interacting protein C-terminus
    8. XM_047416019.1XP_047271975.1  folliculin-interacting protein 2 isoform X7

    9. XM_047416022.1XP_047271978.1  folliculin-interacting protein 2 isoform X9

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      162119774..162258820
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054350604.1XP_054206579.1  folliculin-interacting protein 2 isoform X2

    2. XM_054350607.1XP_054206582.1  folliculin-interacting protein 2 isoform X5

    3. XM_054350603.1XP_054206578.1  folliculin-interacting protein 2 isoform X1

    4. XM_054350606.1XP_054206581.1  folliculin-interacting protein 2 isoform X4

    5. XM_054350608.1XP_054206583.1  folliculin-interacting protein 2 isoform X6

    6. XM_054350611.1XP_054206586.1  folliculin-interacting protein 2 isoform X8

    7. XM_054350605.1XP_054206580.1  folliculin-interacting protein 2 isoform X3

    8. XM_054350609.1XP_054206584.1  folliculin-interacting protein 2 isoform X7

    9. XM_054350610.1XP_054206585.1  folliculin-interacting protein 2 isoform X10

    10. XM_054350612.1XP_054206587.1  folliculin-interacting protein 2 isoform X9