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    FAM135A family with sequence similarity 135 member A [ Homo sapiens (human) ]

    Gene ID: 57579, updated on 17-Jun-2024

    Summary

    Official Symbol
    FAM135Aprovided by HGNC
    Official Full Name
    family with sequence similarity 135 member Aprovided by HGNC
    Primary source
    HGNC:HGNC:21084
    See related
    Ensembl:ENSG00000082269 AllianceGenome:HGNC:21084
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KIAA1411
    Summary
    Predicted to be involved in cellular lipid metabolic process. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in esophagus (RPKM 17.6), prostate (RPKM 12.9) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FAM135A in Genome Data Viewer
    Location:
    6q13
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (70413508..70561174)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (71594068..71741718)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (71123211..71270877)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105377848 Neighboring gene Sharpr-MPRA regulatory region 4194 Neighboring gene uncharacterized LOC105377847 Neighboring gene long intergenic non-protein coding RNA 1610 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17317 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17318 Neighboring gene FAM135A antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24732 Neighboring gene RNA, U7 small nuclear 48 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17319 Neighboring gene succinate dehydrogenase complex assembly factor 4 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr6:71310594-71311158 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:71318535-71319052 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:71319053-71319569 Neighboring gene spermine synthase pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ13577, KIAA1411, DKFZp781H2319

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in cellular lipid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_054903.1 RefSeqGene

      Range
      5105..152771
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001105531.3NP_001099001.1  protein FAM135A isoform a

      Status: VALIDATED

      Source sequence(s)
      AB037832, AJ420590, BC131782, DB462733
      Consensus CDS
      CCDS47448.1
      UniProtKB/Swiss-Prot
      Q9P2D6
      Related
      ENSP00000354913.3, ENST00000361499.7
      Conserved Domains (2) summary
      pfam05057
      Location:10481243
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein of unknown function (DUF3657)
    2. NM_001162529.3NP_001156001.1  protein FAM135A isoform c

      See identical proteins and their annotated locations for NP_001156001.1

      Status: VALIDATED

      Source sequence(s)
      AL078591, AL365226
      Consensus CDS
      CCDS55028.1
      UniProtKB/Swiss-Prot
      A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
      Related
      ENSP00000410768.2, ENST00000418814.7
      Conserved Domains (2) summary
      pfam05057
      Location:12441439
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    3. NM_001330995.3NP_001317924.1  protein FAM135A isoform d

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Consensus CDS
      CCDS83104.1
      UniProtKB/TrEMBL
      D6RCC7
    4. NM_001330996.3NP_001317925.1  protein FAM135A isoform e

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Conserved Domains (2) summary
      pfam05057
      Location:12701465
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    5. NM_001330997.3NP_001317926.1  protein FAM135A isoform a

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Consensus CDS
      CCDS47448.1
      UniProtKB/Swiss-Prot
      Q9P2D6
      Conserved Domains (2) summary
      pfam05057
      Location:10481243
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein of unknown function (DUF3657)
    6. NM_001330998.3NP_001317927.1  protein FAM135A isoform f

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Conserved Domains (2) summary
      pfam05057
      Location:10741269
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein of unknown function (DUF3657)
    7. NM_001330999.3NP_001317928.1  protein FAM135A isoform e

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Conserved Domains (2) summary
      pfam05057
      Location:12701465
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    8. NM_001331000.3NP_001317929.1  protein FAM135A isoform g

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
    9. NM_001331001.3NP_001317930.1  protein FAM135A isoform a

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Consensus CDS
      CCDS47448.1
      UniProtKB/Swiss-Prot
      Q9P2D6
      Conserved Domains (2) summary
      pfam05057
      Location:10481243
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein of unknown function (DUF3657)
    10. NM_001331002.3NP_001317931.1  protein FAM135A isoform a

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Consensus CDS
      CCDS47448.1
      UniProtKB/Swiss-Prot
      Q9P2D6
      Conserved Domains (2) summary
      pfam05057
      Location:10481243
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein of unknown function (DUF3657)
    11. NM_001331003.3NP_001317932.1  protein FAM135A isoform f

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Conserved Domains (2) summary
      pfam05057
      Location:10741269
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein of unknown function (DUF3657)
    12. NM_001331004.3NP_001317933.1  protein FAM135A isoform h

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
    13. NM_001331005.3NP_001317934.1  protein FAM135A isoform i

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
    14. NM_001331006.3NP_001317935.1  protein FAM135A isoform j

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Conserved Domains (2) summary
      pfam05057
      Location:8501045
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein of unknown function (DUF3657)
    15. NM_001351599.2NP_001338528.1  protein FAM135A isoform e

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Conserved Domains (2) summary
      pfam05057
      Location:12701465
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    16. NM_001351600.2NP_001338529.1  protein FAM135A isoform c

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Consensus CDS
      CCDS55028.1
      UniProtKB/Swiss-Prot
      A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
      Related
      ENSP00000359510.4, ENST00000370479.7
      Conserved Domains (2) summary
      pfam05057
      Location:12441439
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    17. NM_001351602.2NP_001338531.1  protein FAM135A isoform c

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Consensus CDS
      CCDS55028.1
      UniProtKB/Swiss-Prot
      A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
      Conserved Domains (2) summary
      pfam05057
      Location:12441439
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    18. NM_001351607.2NP_001338536.1  protein FAM135A isoform c

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Consensus CDS
      CCDS55028.1
      UniProtKB/Swiss-Prot
      A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
      Conserved Domains (2) summary
      pfam05057
      Location:12441439
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    19. NM_001351608.2NP_001338537.1  protein FAM135A isoform k

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Conserved Domains (2) summary
      pfam05057
      Location:9621157
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:2585
      DUF3657; Protein FAM135
    20. NM_001351609.2NP_001338538.1  protein FAM135A isoform l

      Status: VALIDATED

      Source sequence(s)
      AJ420590, AL078591, AL365226
      Conserved Domains (2) summary
      pfam05057
      Location:764959
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:2585
      DUF3657; Protein FAM135
    21. NM_020819.5NP_065870.3  protein FAM135A isoform b

      Status: VALIDATED

      Source sequence(s)
      AB037832, AJ420590, BC131782, CR749254, DB462733
      Consensus CDS
      CCDS34481.1
      UniProtKB/Swiss-Prot
      Q9P2D6
      Related
      ENSP00000409201.2, ENST00000457062.6
      Conserved Domains (2) summary
      pfam05057
      Location:10311226
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:68128
      DUF3657; Protein of unknown function (DUF3657)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      70413508..70561174
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419158.1XP_047275114.1  protein FAM135A isoform X1

    2. XM_047419165.1XP_047275121.1  protein FAM135A isoform X4

    3. XM_047419169.1XP_047275125.1  protein FAM135A isoform X8

    4. XM_047419175.1XP_047275131.1  protein FAM135A isoform X9

      UniProtKB/TrEMBL
      D6RCC7
    5. XM_005248749.2XP_005248806.1  protein FAM135A isoform X6

      Conserved Domains (2) summary
      pfam05057
      Location:10461241
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein of unknown function (DUF3657)
    6. XM_047419168.1XP_047275124.1  protein FAM135A isoform X7

    7. XM_011535995.4XP_011534297.1  protein FAM135A isoform X1

      See identical proteins and their annotated locations for XP_011534297.1

      Conserved Domains (2) summary
      pfam05057
      Location:12701465
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    8. XM_047419162.1XP_047275118.1  protein FAM135A isoform X4

    9. XM_047419171.1XP_047275127.1  protein FAM135A isoform X8

    10. XM_047419159.1XP_047275115.1  protein FAM135A isoform X2

      UniProtKB/Swiss-Prot
      A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
    11. XM_047419167.1XP_047275123.1  protein FAM135A isoform X5

    12. XM_047419180.1XP_047275136.1  protein FAM135A isoform X9

      UniProtKB/TrEMBL
      D6RCC7
    13. XM_011535994.3XP_011534296.1  protein FAM135A isoform X1

      See identical proteins and their annotated locations for XP_011534296.1

      Conserved Domains (2) summary
      pfam05057
      Location:12701465
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    14. XM_047419173.1XP_047275129.1  protein FAM135A isoform X8

    15. XM_047419166.1XP_047275122.1  protein FAM135A isoform X5

    16. XM_047419176.1XP_047275132.1  protein FAM135A isoform X9

      UniProtKB/TrEMBL
      D6RCC7
    17. XM_011535996.3XP_011534298.1  protein FAM135A isoform X1

      See identical proteins and their annotated locations for XP_011534298.1

      Conserved Domains (2) summary
      pfam05057
      Location:12701465
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    18. XM_047419163.1XP_047275119.1  protein FAM135A isoform X4

    19. XM_047419172.1XP_047275128.1  protein FAM135A isoform X8

    20. XM_047419160.1XP_047275116.1  protein FAM135A isoform X2

      UniProtKB/Swiss-Prot
      A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
    21. XM_047419179.1XP_047275135.1  protein FAM135A isoform X9

      UniProtKB/TrEMBL
      D6RCC7
    22. XM_047419164.1XP_047275120.1  protein FAM135A isoform X4

    23. XM_047419174.1XP_047275130.1  protein FAM135A isoform X8

    24. XM_017011127.2XP_016866616.1  protein FAM135A isoform X2

      UniProtKB/Swiss-Prot
      A2RRQ5, Q3C0H3, Q5JXK0, Q5JXK1, Q68DW0, Q6P081, Q9H0F2, Q9NU48, Q9NUQ5, Q9NXL5, Q9P2D6
      Related
      ENSP00000423307.1, ENST00000505868.1
      Conserved Domains (2) summary
      pfam05057
      Location:12441439
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:111171
      DUF3657; Protein FAM135
    25. XM_047419178.1XP_047275134.1  protein FAM135A isoform X9

      UniProtKB/TrEMBL
      D6RCC7
      Related
      ENSP00000423785.1, ENST00000505769.5
    26. XM_011535997.3XP_011534299.1  protein FAM135A isoform X3

      Conserved Domains (2) summary
      pfam05057
      Location:12371432
      DUF676; Putative serine esterase (DUF676)
      pfam12394
      Location:78138
      DUF3657; Protein of unknown function (DUF3657)
    27. XM_047419161.1XP_047275117.1  protein FAM135A isoform X4

    28. XM_047419170.1XP_047275126.1  protein FAM135A isoform X8

    29. XM_047419177.1XP_047275133.1  protein FAM135A isoform X9

      UniProtKB/TrEMBL
      D6RCC7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      71594068..71741718
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356070.1XP_054212045.1  protein FAM135A isoform X1

    2. XM_054356079.1XP_054212054.1  protein FAM135A isoform X4

    3. XM_054356084.1XP_054212059.1  protein FAM135A isoform X8

    4. XM_054356090.1XP_054212065.1  protein FAM135A isoform X9

    5. XM_054356082.1XP_054212057.1  protein FAM135A isoform X6

    6. XM_054356083.1XP_054212058.1  protein FAM135A isoform X7

    7. XM_054356069.1XP_054212044.1  protein FAM135A isoform X1

    8. XM_054356076.1XP_054212051.1  protein FAM135A isoform X4

    9. XM_054356086.1XP_054212061.1  protein FAM135A isoform X8

    10. XM_054356071.1XP_054212046.1  protein FAM135A isoform X2

    11. XM_054356081.1XP_054212056.1  protein FAM135A isoform X5

    12. XM_054356095.1XP_054212070.1  protein FAM135A isoform X9

    13. XM_054356067.1XP_054212042.1  protein FAM135A isoform X1

    14. XM_054356088.1XP_054212063.1  protein FAM135A isoform X8

    15. XM_054356080.1XP_054212055.1  protein FAM135A isoform X5

    16. XM_054356091.1XP_054212066.1  protein FAM135A isoform X9

    17. XM_054356068.1XP_054212043.1  protein FAM135A isoform X1

    18. XM_054356077.1XP_054212052.1  protein FAM135A isoform X4

    19. XM_054356087.1XP_054212062.1  protein FAM135A isoform X8

    20. XM_054356072.1XP_054212047.1  protein FAM135A isoform X2

    21. XM_054356094.1XP_054212069.1  protein FAM135A isoform X9

    22. XM_054356078.1XP_054212053.1  protein FAM135A isoform X4

    23. XM_054356089.1XP_054212064.1  protein FAM135A isoform X8

    24. XM_054356073.1XP_054212048.1  protein FAM135A isoform X2

    25. XM_054356093.1XP_054212068.1  protein FAM135A isoform X9

    26. XM_054356074.1XP_054212049.1  protein FAM135A isoform X3

    27. XM_054356075.1XP_054212050.1  protein FAM135A isoform X4

    28. XM_054356085.1XP_054212060.1  protein FAM135A isoform X8

    29. XM_054356092.1XP_054212067.1  protein FAM135A isoform X9