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    MARCHF4 membrane associated ring-CH-type finger 4 [ Homo sapiens (human) ]

    Gene ID: 57574, updated on 17-Jun-2024

    Summary

    Official Symbol
    MARCHF4provided by HGNC
    Official Full Name
    membrane associated ring-CH-type finger 4provided by HGNC
    Primary source
    HGNC:HGNC:29269
    See related
    Ensembl:ENSG00000144583 MIM:608208; AllianceGenome:HGNC:29269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MARCH4; RNF174; MARCH-IV
    Summary
    MARCH4 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH4 reduces surface accumulation of several membrane glycoproteins by directing them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]
    Expression
    Biased expression in brain (RPKM 3.9), stomach (RPKM 1.1) and 2 other tissues See more
    Orthologs
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    Genomic context

    See MARCHF4 in Genome Data Viewer
    Location:
    2q35
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (216257865..216372483, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (216740406..216854601, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (217122588..217237206, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene X-ray repair cross complementing 5 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17093 Neighboring gene long intergenic non-protein coding RNA 1963 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217147950-217148470 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217148471-217148990 Neighboring gene uncharacterized LOC107985983 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:217180211-217181410 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:217183431-217184162 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:217184163-217184894 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217205324-217206036 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217214111-217214808 Neighboring gene SMARCAL1 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:217256655-217257184 Neighboring gene uncharacterized LOC107985984 Neighboring gene Sharpr-MPRA regulatory region 13820 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17096 Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:217339556-217340056

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analysis identifies susceptibility loci for migraine without aura.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC104908

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in Golgi stack IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi stack IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in trans-Golgi network IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in trans-Golgi network IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase MARCHF4
    Names
    E3 ubiquitin-protein ligase MARCH4
    RING finger protein 174
    RING-type E3 ubiquitin transferase MARCH4
    RING-type E3 ubiquitin transferase MARCHF4
    membrane associated ring finger 4
    membrane-associated RING finger protein 4
    membrane-associated RING-CH protein IV
    membrane-associated ring finger (C3HC4) 4, E3 ubiquitin protein ligase
    NP_065865.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020814.3NP_065865.1  E3 ubiquitin-protein ligase MARCHF4 precursor

      See identical proteins and their annotated locations for NP_065865.1

      Status: VALIDATED

      Source sequence(s)
      AB037820, AC012513, AC098820, AW051292, BC048793, BC098448
      Consensus CDS
      CCDS33376.1
      UniProtKB/Swiss-Prot
      Q4KMN7, Q86WR8, Q9P2E8
      Related
      ENSP00000273067.3, ENST00000273067.5
      Conserved Domains (1) summary
      smart00744
      Location:163208
      RINGv; The RING-variant domain is a C4HC3 zinc-finger like motif found in a number of cellular and viral proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      216257865..216372483 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      216740406..216854601 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)