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    ARHGAP20 Rho GTPase activating protein 20 [ Homo sapiens (human) ]

    Gene ID: 57569, updated on 23-Nov-2021

    Summary

    Official Symbol
    ARHGAP20provided by HGNC
    Official Full Name
    Rho GTPase activating protein 20provided by HGNC
    Primary source
    HGNC:HGNC:18357
    See related
    Ensembl:ENSG00000137727 MIM:609568
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    RARHOGAP
    Summary
    The protein encoded by this gene is an activator of RHO-type GTPases, transducing a signal from RAP1 to RHO and impacting neurite outgrowth. [provided by RefSeq, Sep 2016]
    Expression
    Broad expression in fat (RPKM 5.7), testis (RPKM 5.0) and 20 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See ARHGAP20 in Genome Data Viewer
    Location:
    11q22.3-q23.1
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    109.20211119 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (110577035..110713189, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (110447767..110583912, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369487 Neighboring gene ferredoxin 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 60 Neighboring gene uncharacterized LOC105369488

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
    GeneReviews: Not available
    Genome-wide association study of the rate of cognitive decline in Alzheimer's disease.
    GeneReviews: Not available
    Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.
    GeneReviews: Not available

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Clone Names

    • KIAA1391

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables GTPase activator activity TAS
    Traceable Author Statement
    more info
     
    Process Evidence Code Pubs
    involved_in regulation of catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of small GTPase mediated signal transduction TAS
    Traceable Author Statement
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    rho GTPase-activating protein 20
    Names
    RA and RhoGAP domain containing protein
    rho GTPase activating protein 20 variant 2
    rho-type GTPase-activating protein 20

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051657.1 RefSeqGene

      Range
      5462..141155
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001258415.2NP_001245344.1  rho GTPase-activating protein 20 isoform 2

      See identical proteins and their annotated locations for NP_001245344.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AP001883, AY496266
      Consensus CDS
      CCDS58177.1
      UniProtKB/Swiss-Prot
      Q9P2F6
      Related
      ENSP00000432076.1, ENST00000524756.5
      Conserved Domains (3) summary
      cd04402
      Location:339532
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
      cd13319
      Location:61157
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      pfam00788
      Location:175251
      RA; Ras association (RalGDS/AF-6) domain
    2. NM_001258416.2NP_001245345.1  rho GTPase-activating protein 20 isoform 3

      See identical proteins and their annotated locations for NP_001245345.1

      Status: REVIEWED

      Source sequence(s)
      AP001883, AP001980, AP003460
      Consensus CDS
      CCDS58176.1
      UniProtKB/Swiss-Prot
      Q9P2F6
      Related
      ENSP00000436522.1, ENST00000533353.5
      Conserved Domains (3) summary
      cd04402
      Location:336529
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
      cd13319
      Location:58154
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      pfam00788
      Location:172248
      RA; Ras association (RalGDS/AF-6) domain
    3. NM_001258417.2NP_001245346.1  rho GTPase-activating protein 20 isoform 4

      See identical proteins and their annotated locations for NP_001245346.1

      Status: REVIEWED

      Source sequence(s)
      AP001883, AP001980, AP003460
      Consensus CDS
      CCDS58175.1
      UniProtKB/Swiss-Prot
      Q9P2F6
      Related
      ENSP00000436319.1, ENST00000528829.5
      Conserved Domains (3) summary
      cd04402
      Location:326519
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
      cd13319
      Location:48144
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      pfam00788
      Location:162238
      RA; Ras association (RalGDS/AF-6) domain
    4. NM_001258418.2NP_001245347.1  rho GTPase-activating protein 20 isoform 4

      See identical proteins and their annotated locations for NP_001245347.1

      Status: REVIEWED

      Source sequence(s)
      AP001883, AP001980, AP003460
      Consensus CDS
      CCDS58175.1
      UniProtKB/Swiss-Prot
      Q9P2F6
      Related
      ENSP00000431399.1, ENST00000527598.1
      Conserved Domains (3) summary
      cd04402
      Location:326519
      RhoGAP_ARHGAP20; RhoGAP_ARHGAP20: RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by ...
      cd13319
      Location:48144
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      pfam00788
      Location:162238
      RA; Ras association (RalGDS/AF-6) domain
    5. NM_001384657.1NP_001371586.1  rho GTPase-activating protein 20 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP001883, AP001980, AP003460
      Related
      ENSP00000507405.1, ENST00000683387.1
      Conserved Domains (3) summary
      cd04402
      Location:362555
      RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...
      cd13319
      Location:84180
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      cd17115
      Location:194312
      RA_RHG20; Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar proteins
    6. NM_020809.4NP_065860.2  rho GTPase-activating protein 20 isoform 1

      See identical proteins and their annotated locations for NP_065860.2

      Status: REVIEWED

      Source sequence(s)
      AP001883, AP001980, AP003460
      Consensus CDS
      CCDS31673.1
      UniProtKB/Swiss-Prot
      Q9P2F6
      Related
      ENSP00000260283.4, ENST00000260283.8
      Conserved Domains (3) summary
      cd04402
      Location:362555
      RhoGAP_ARHGAP20; RhoGAP (GTPase-activator protein [GAP] for Rho-like small GTPases) domain of ArhGAP20-like proteins. ArhGAP20, also known as KIAA1391 and RA-RhoGAP, contains a RhoGAP, a RA, and a PH domain, and ANXL repeats. ArhGAP20 is activated by Rap1 and induces ...
      cd13319
      Location:84180
      PH_RARhoGAP; RA and RhoGAP domain-containing protein Pleckstrin homology PH domain
      cd17115
      Location:194312
      RA_RHG20; Ras-associating (RA) domain found in Rho GTPase-activating protein 20 (RHG20) and similar proteins

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

      Range
      110577035..110713189 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271628.3XP_005271685.1  rho GTPase-activating protein 20 isoform X2

      Related
      ENSP00000437905.1, ENST00000529591.5
      Conserved Domains (1) summary
      cl02570
      Location:198
      RhoGAP; RhoGAP: GTPase-activator protein (GAP) for Rho-like GTPases; GAPs towards Rho/Rac/Cdc42-like small GTPases. Small GTPases (G proteins) cluster into distinct families, and all act as molecular switches, active in their GTP-bound form but inactive when ...
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