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    STAMBPL1 STAM binding protein like 1 [ Homo sapiens (human) ]

    Gene ID: 57559, updated on 11-Apr-2024

    Summary

    Official Symbol
    STAMBPL1provided by HGNC
    Official Full Name
    STAM binding protein like 1provided by HGNC
    Primary source
    HGNC:HGNC:24105
    See related
    Ensembl:ENSG00000138134 MIM:612352; AllianceGenome:HGNC:24105
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AMSH-FP; AMSH-LP; ALMalpha; bA399O19.2
    Summary
    Predicted to enable Lys63-specific deubiquitinase activity and thiol-dependent deubiquitinase. Predicted to be involved in protein K63-linked deubiquitination. Located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in adrenal (RPKM 7.5), testis (RPKM 6.2) and 22 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    10q23.31
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (88880245..88923487)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (89763682..89807429)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (90640002..90683244)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3725 Neighboring gene lipase family member M Neighboring gene ankyrin repeat domain 22 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3726 Neighboring gene uncharacterized LOC124902551 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3727 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:90641731-90642930 Neighboring gene pentatricopeptide repeat domain 2 pseudogene 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3728 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3731 Neighboring gene ACTA2 antisense RNA 1 Neighboring gene actin alpha 2, smooth muscle Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:90749708-90750219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:90750220-90750730 Neighboring gene Fas cell surface death receptor Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3732 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3733 Neighboring gene FAS antisense RNA 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ31524, KIAA1373

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables K63-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables K63-linked deubiquitinase activity TAS
    Traceable Author Statement
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to L-leucine IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of TORC1 signaling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane HDA PubMed 
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    AMSH-like protease
    Names
    associated molecule with the SH3 domain of STAM (AMSH) - Family Protein
    associated molecule with the SH3 domain of STAM (AMSH) like protein
    NP_065850.1
    XP_006717993.1
    XP_011538285.1
    XP_011538287.1
    XP_016871945.1
    XP_016871946.1
    XP_016871947.1
    XP_047281507.1
    XP_047281508.1
    XP_047281509.1
    XP_047281510.1
    XP_047281511.1
    XP_054222371.1
    XP_054222372.1
    XP_054222373.1
    XP_054222374.1
    XP_054222375.1
    XP_054222376.1
    XP_054222377.1
    XP_054222378.1
    XP_054222379.1
    XP_054222380.1
    XP_054222381.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020799.4NP_065850.1  AMSH-like protease

      See identical proteins and their annotated locations for NP_065850.1

      Status: VALIDATED

      Source sequence(s)
      AK056086, AW006657, CD244526
      Consensus CDS
      CCDS7391.1
      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Related
      ENSP00000360994.3, ENST00000371926.8
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      88880245..88923487
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425551.1XP_047281507.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    2. XM_011539985.3XP_011538287.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_011538287.1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    3. XM_006717930.4XP_006717993.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_006717993.1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    4. XM_047425553.1XP_047281509.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    5. XM_011539983.2XP_011538285.1  AMSH-like protease isoform X1

      See identical proteins and their annotated locations for XP_011538285.1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    6. XM_047425555.1XP_047281511.1  AMSH-like protease isoform X2

    7. XM_047425552.1XP_047281508.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    8. XM_017016456.2XP_016871945.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
      UniProtKB/TrEMBL
      B3KS69
      Conserved Domains (3) summary
      cd08066
      Location:266436
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:28129
      USP8_dimer; USP8 dimerization domain
      cl20817
      Location:120198
      GBP_C; Guanylate-binding protein, C-terminal domain
    9. XM_017016457.3XP_016871946.1  AMSH-like protease isoform X2

      UniProtKB/TrEMBL
      B3KS69
    10. XM_047425554.1XP_047281510.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    11. XM_017016458.2XP_016871947.1  AMSH-like protease isoform X3

      UniProtKB/TrEMBL
      B3KR00
      Conserved Domains (2) summary
      cd08066
      Location:160330
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      COG0544
      Location:1391
      Tig; FKBP-type peptidyl-prolyl cis-trans isomerase (trigger factor) [Posttranslational modification, protein turnover, chaperones]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      89763682..89807429
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366396.1XP_054222371.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    2. XM_054366400.1XP_054222375.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    3. XM_054366401.1XP_054222376.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    4. XM_054366402.1XP_054222377.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    5. XM_054366398.1XP_054222373.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    6. XM_054366405.1XP_054222380.1  AMSH-like protease isoform X2

    7. XM_054366399.1XP_054222374.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    8. XM_054366397.1XP_054222372.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    9. XM_054366404.1XP_054222379.1  AMSH-like protease isoform X2

    10. XM_054366403.1XP_054222378.1  AMSH-like protease isoform X1

      UniProtKB/Swiss-Prot
      B3KPA7, Q5T9N4, Q5T9N9, Q7Z420, Q96FJ0, Q9P2H4
    11. XM_054366406.1XP_054222381.1  AMSH-like protease isoform X3