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    GPR158 G protein-coupled receptor 158 [ Homo sapiens (human) ]

    Gene ID: 57512, updated on 5-May-2024

    Summary

    Official Symbol
    GPR158provided by HGNC
    Official Full Name
    G protein-coupled receptor 158provided by HGNC
    Primary source
    HGNC:HGNC:23689
    See related
    Ensembl:ENSG00000151025 MIM:614573; AllianceGenome:HGNC:23689
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    mGlyR
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway and protein localization to plasma membrane. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in brain (RPKM 11.3), adrenal (RPKM 0.9) and 1 other tissue See more
    Orthologs
    NEW
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    Genomic context

    Location:
    10p12.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (25175001..25602229)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (25193234..25626794)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (25463930..25891158)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2230 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:25305216-25305978 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3161 Neighboring gene threonine synthase like 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3162 Neighboring gene enkurin, TRPC channel interacting protein Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:25348855-25350054 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:25350646-25351845 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:25356859-25358058 Neighboring gene NANOG hESC enhancer GRCh37_chr10:25394727-25395330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2233 Neighboring gene long intergenic non-protein coding RNA 1516 Neighboring gene GPR158 antisense RNA 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:25542036-25542637 Neighboring gene RN7SK pseudogene 220 Neighboring gene Sharpr-MPRA regulatory region 12818 Neighboring gene MPRA-validated peak912 silencer Neighboring gene long intergenic non-protein coding RNA 836 Neighboring gene GPN-loop GTPase 3 pseudogene 1 Neighboring gene histone cell cycle regulator pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.
    EBI GWAS Catalog
    Genome-wide association study of antibody response to smallpox vaccine.
    EBI GWAS Catalog
    Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ37801, KIAA1136

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables G protein-coupled glycine receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables enzyme activator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transmembrane signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in brain development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cognition ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in positive regulation of neurotransmitter secretion ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in protein localization to plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    metabotropic glycine receptor
    Names
    probable G-protein coupled receptor 158

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020752.3NP_065803.2  metabotropic glycine receptor precursor

      See identical proteins and their annotated locations for NP_065803.2

      Status: VALIDATED

      Source sequence(s)
      AL139821, AL161654, AL355587, AY528411
      Consensus CDS
      CCDS31166.1
      UniProtKB/Swiss-Prot
      Q5T848, Q6QR81, Q9ULT3
      UniProtKB/TrEMBL
      A0A3B3IUC3
      Related
      ENSP00000365529.3, ENST00000376351.4
      Conserved Domains (1) summary
      pfam00003
      Location:428667
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      25175001..25602229
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016452.3XP_016871941.1  metabotropic glycine receptor isoform X1

    RNA

    1. XR_930512.4 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      25193234..25626794
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_008488243.1 RNA Sequence