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    PTGER4 prostaglandin E receptor 4 [ Homo sapiens (human) ]

    Gene ID: 5734, updated on 24-Sep-2024

    Summary

    Official Symbol
    PTGER4provided by HGNC
    Official Full Name
    prostaglandin E receptor 4provided by HGNC
    Primary source
    HGNC:HGNC:9596
    See related
    Ensembl:ENSG00000171522 MIM:601586; AllianceGenome:HGNC:9596
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EP4; EP4R
    Summary
    The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor signaling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygenase-2 mRNA, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neonatal adaptation of circulatory system, osteoporosis, as well as initiation of skin immune responses. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in bone marrow (RPKM 30.5), colon (RPKM 12.1) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PTGER4 in Genome Data Viewer
    Location:
    5p13.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (40679915..40746800)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (40936331..41003197)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (40680017..40693837)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374737 Neighboring gene small nucleolar RNA SNORA63 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:40681035-40681562 Neighboring gene tetratricopeptide repeat domain 33 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22503 Neighboring gene uncharacterized LOC124900968 Neighboring gene protein kinase AMP-activated catalytic subunit alpha 1 Neighboring gene HNF1 motif-containing MPRA enhancer 12 Neighboring gene small nucleolar RNA SNORA57

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.
    EBI GWAS Catalog
    A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.
    EBI GWAS Catalog
    A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.
    EBI GWAS Catalog
    A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
    EBI GWAS Catalog
    Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis.
    EBI GWAS Catalog
    Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease.
    EBI GWAS Catalog
    Genome-wide association study of multiple sclerosis confirms a novel locus at 5p13.1.
    EBI GWAS Catalog
    Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog
    Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.
    EBI GWAS Catalog
    Systematic association mapping identifies NELL1 as a novel IBD disease gene.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag Prostaglandin E2 downregulates HIV-1 CA/p24 production through the EP2 and EP4 receptors PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126583

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables prostaglandin E receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prostaglandin E receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in ERK1 and ERK2 cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in JNK cascade ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in T-helper cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in bone development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to mechanical stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to prostaglandin E stimulus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in immune response IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of eosinophil extravasation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of inflammatory response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of integrin activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokine production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cytosolic calcium ion concentration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of ossification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of stress fiber assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to lipopolysaccharide IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to nematode IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to prostaglandin E IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    prostaglandin E2 receptor EP4 subtype
    Names
    PGE receptor, EP4 subtype
    PGE2 receptor EP4 subtype
    prostaglandin E receptor 4 (subtype EP4)
    prostanoid EP4 receptor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047000.1 RefSeqGene

      Range
      5418..19238
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000958.3NP_000949.1  prostaglandin E2 receptor EP4 subtype

      See identical proteins and their annotated locations for NP_000949.1

      Status: REVIEWED

      Source sequence(s)
      AC093264, BC027934, BM312677, BQ029720, CD000197, L28175
      Consensus CDS
      CCDS3930.1
      UniProtKB/Swiss-Prot
      P35408, Q3MJ87
      Related
      ENSP00000302846.3, ENST00000302472.4
      Conserved Domains (1) summary
      cd15142
      Location:18341
      7tmA_PGE2_EP4; prostaglandin E2 receptor EP4 subtype, member of the class A family of seven-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      40679915..40746800
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009659.3XP_016865148.1  prostaglandin E2 receptor EP4 subtype isoform X3

      Conserved Domains (2) summary
      pfam00001
      Location:34222
      7tm_1; 7 transmembrane receptor (rhodopsin family)
      cl21561
      Location:29216
      7tm_4; Olfactory receptor
    2. XM_047417415.1XP_047273371.1  prostaglandin E2 receptor EP4 subtype isoform X3

    3. XM_047417413.1XP_047273369.1  prostaglandin E2 receptor EP4 subtype isoform X1

    4. XM_047417414.1XP_047273370.1  prostaglandin E2 receptor EP4 subtype isoform X2

    5. XM_047417416.1XP_047273372.1  prostaglandin E2 receptor EP4 subtype isoform X4

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      40936331..41003197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352960.1XP_054208935.1  prostaglandin E2 receptor EP4 subtype isoform X3

    2. XM_054352961.1XP_054208936.1  prostaglandin E2 receptor EP4 subtype isoform X3

    3. XM_054352958.1XP_054208933.1  prostaglandin E2 receptor EP4 subtype isoform X1

    4. XM_054352959.1XP_054208934.1  prostaglandin E2 receptor EP4 subtype isoform X2

    5. XM_054352962.1XP_054208937.1  prostaglandin E2 receptor EP4 subtype isoform X4