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    Wdr46 WD repeat domain 46 [ Mus musculus (house mouse) ]

    Gene ID: 57315, updated on 9-Dec-2024

    Summary

    Official Symbol
    Wdr46provided by MGI
    Official Full Name
    WD repeat domain 46provided by MGI
    Primary source
    MGI:MGI:1931871
    See related
    Ensembl:ENSMUSG00000024312 AllianceGenome:MGI:1931871
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bing4; 2310007I04Rik
    Summary
    Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Predicted to be part of small-subunit processome. Predicted to be active in nucleolus. Is expressed in several structures, including central nervous system; genitourinary system; hemolymphoid system gland; liver; and retina. Orthologous to human WDR46 (WD repeat domain 46). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 12.7), liver E14.5 (RPKM 12.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Wdr46 in Genome Data Viewer
    Location:
    17 B1; 17 17.98 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (34159608..34168669)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (33940634..33949695)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:34066718-34066827 Neighboring gene ral guanine nucleotide dissociation stimulator-like 2 Neighboring gene STARR-positive B cell enhancer ABC_E1938 Neighboring gene prefoldin subunit 6 Neighboring gene UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 4 Neighboring gene STARR-positive B cell enhancer ABC_E8668 Neighboring gene ribosomal protein S18 Neighboring gene STARR-positive B cell enhancer ABC_E3199

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    WD repeat-containing protein 46
    Names
    WD repeat-containing protein BING4
    putative WD repeat domain 46

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020603.2NP_065628.1  WD repeat-containing protein 46

      See identical proteins and their annotated locations for NP_065628.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046977
      Consensus CDS
      CCDS28637.1
      UniProtKB/Swiss-Prot
      Q9Z0H1
      UniProtKB/TrEMBL
      A0A068BFS0
      Related
      ENSMUSP00000025170.10, ENSMUST00000025170.11
      Conserved Domains (4) summary
      smart01033
      Location:439517
      BING4CT; BING4CT (NUC141) domain
      COG2319
      Location:202389
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:198234
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:238456
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      34159608..34168669
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524697.2XP_006524760.1  WD repeat-containing protein 46 isoform X1

      See identical proteins and their annotated locations for XP_006524760.1

      UniProtKB/TrEMBL
      A0A068BFS0
      Conserved Domains (4) summary
      smart01033
      Location:453531
      BING4CT; BING4CT (NUC141) domain
      TIGR02223
      Location:32142
      ftsN; cell division protein FtsN
      sd00039
      Location:212248
      7WD40; WD40 repeat [structural motif]
      cl29593
      Location:252470
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...