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    Nelfcd negative elongation factor complex member C/D, Th1l [ Mus musculus (house mouse) ]

    Gene ID: 57314, updated on 6-Jun-2024

    Summary

    Official Symbol
    Nelfcdprovided by MGI
    Official Full Name
    negative elongation factor complex member C/D, Th1lprovided by MGI
    Primary source
    MGI:MGI:1926424
    See related
    Ensembl:ENSMUSG00000016253 AllianceGenome:MGI:1926424
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Th1; Th1l; NELF-D; 2410003I03Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in negative regulation of transcription elongation from RNA polymerase II promoter. Predicted to be located in nucleus. Predicted to be part of NELF complex. Is expressed in 1st branchial arch; 1st branchial arch maxillary component; limb; limb mesenchyme; and maxillary process. Orthologous to human NELFCD (negative elongation factor complex member C/D). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 31.1), limb E14.5 (RPKM 29.5) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nelfcd in Genome Data Viewer
    Location:
    2 H4; 2 97.93 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (174257623..174269298)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (174415804..174427505)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_06635 Neighboring gene GNAS antisense RNA 1 Neighboring gene STARR-seq mESC enhancer starr_06637 Neighboring gene GNAS complex locus Neighboring gene STARR-seq mESC enhancer starr_06638 Neighboring gene STARR-positive B cell enhancer ABC_E10168 Neighboring gene predicted gene, 30189 Neighboring gene STARR-positive B cell enhancer ABC_E1611 Neighboring gene STARR-positive B cell enhancer ABC_E1612 Neighboring gene STARR-positive B cell enhancer ABC_E6030 Neighboring gene cathepsin Z Neighboring gene ribosomal protein L30, pseudogene 5 Neighboring gene tubulin, beta 1 class VI

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of NELF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of NELF complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    negative elongation factor D
    Names
    TH1 homolog
    TH1-like homolog
    TH1-like protein
    trihydrophobin 1 homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020580.4NP_065605.3  negative elongation factor D

      Status: VALIDATED

      Source sequence(s)
      AL844534
      Consensus CDS
      CCDS38358.1
      UniProtKB/Swiss-Prot
      A2AQ05, Q922L6, Q9QXC8, Q9QXC9, Q9QXD0
      Related
      ENSMUSP00000104703.2, ENSMUST00000109075.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      174257623..174269298
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499946.4XP_006500009.1  negative elongation factor D isoform X1

      UniProtKB/Swiss-Prot
      A2AQ05, Q922L6, Q9QXC8, Q9QXC9, Q9QXD0
      Conserved Domains (1) summary
      pfam04858
      Location:1530
      TH1; TH1 protein