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    PTGDS prostaglandin D2 synthase [ Homo sapiens (human) ]

    Gene ID: 5730, updated on 17-Jun-2024

    Summary

    Official Symbol
    PTGDSprovided by HGNC
    Official Full Name
    prostaglandin D2 synthaseprovided by HGNC
    Primary source
    HGNC:HGNC:9592
    See related
    Ensembl:ENSG00000107317 MIM:176803; AllianceGenome:HGNC:9592
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PDS; PGD2; PGDS; LPGDS; PGDS2; L-PGDS
    Summary
    The protein encoded by this gene is a glutathione-independent prostaglandin D synthase that catalyzes the conversion of prostaglandin H2 (PGH2) to postaglandin D2 (PGD2). PGD2 functions as a neuromodulator as well as a trophic factor in the central nervous system. PGD2 is also involved in smooth muscle contraction/relaxation and is a potent inhibitor of platelet aggregation. This gene is preferentially expressed in brain. Studies with transgenic mice overexpressing this gene suggest that this gene may be also involved in the regulation of non-rapid eye movement sleep. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in testis (RPKM 1025.8), heart (RPKM 481.7) and 13 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PTGDS in Genome Data Viewer
    Location:
    9q34.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (136977504..136981742)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (149211911..149216153)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139871956..139876194)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2692 Neighboring gene uncharacterized LOC124902312 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139873016-139873995 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139878783-139879340 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:139879341-139879896 Neighboring gene lipocalin like 1 Neighboring gene Sharpr-MPRA regulatory region 3127 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20564 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20565 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:139887067-139887609 Neighboring gene PAXX non-homologous end joining factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.
    EBI GWAS Catalog
    Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    matrix gag HIV-1 MA increases PTGDS mRNA expression in HepG2 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: LCNL1

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fatty acid binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables prostaglandin-D synthase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables prostaglandin-D synthase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables prostaglandin-D synthase activity TAS
    Traceable Author Statement
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables retinoid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cyclooxygenase pathway TAS
    Traceable Author Statement
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mast cell degranulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of male germ cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in prostaglandin biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in prostaglandin biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of circadian sleep/wake cycle, sleep ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in response to glucocorticoid IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in rough endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prostaglandin-H2 D-isomerase
    Names
    PGD2 synthase
    beta-trace protein
    cerebrin-28
    glutathione-independent PGD synthase
    glutathione-independent PGD synthetase
    lipocalin-type prostaglandin D synthase
    prostaglandin D synthase
    prostaglandin D2 synthase 21kDa (brain)
    testis tissue sperm-binding protein Li 63n
    NP_000945.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_000954.6NP_000945.3  prostaglandin-H2 D-isomerase precursor

      See identical proteins and their annotated locations for NP_000945.3

      Status: REVIEWED

      Source sequence(s)
      AL807752
      Consensus CDS
      CCDS7019.1
      UniProtKB/Swiss-Prot
      B2R727, P41222, Q5SQ10, Q7M4P3, Q9UC22, Q9UCC9, Q9UCD9
      UniProtKB/TrEMBL
      A0A024R8G3, Q5SQ11
      Related
      ENSP00000360687.3, ENST00000371625.8
      Conserved Domains (1) summary
      pfam00061
      Location:40184
      Lipocalin; Lipocalin / cytosolic fatty-acid binding protein family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      136977504..136981742
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      149211911..149216153
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)