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    BAG1 BAG cochaperone 1 [ Homo sapiens (human) ]

    Gene ID: 573, updated on 7-Jul-2024

    Summary

    Official Symbol
    BAG1provided by HGNC
    Official Full Name
    BAG cochaperone 1provided by HGNC
    Primary source
    HGNC:HGNC:937
    See related
    Ensembl:ENSG00000107262 MIM:601497; AllianceGenome:HGNC:937
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HAP; BAG-1; RAP46
    Summary
    The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. Multiple protein isoforms are encoded by this mRNA through the use of a non-AUG (CUG) initiation codon, and three alternative downstream AUG initiation codons. A related pseudogene has been defined on chromosome X. [provided by RefSeq, Feb 2010]
    Expression
    Ubiquitous expression in kidney (RPKM 19.7), colon (RPKM 18.5) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See BAG1 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (33252471..33264708, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (33271122..33283355, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (33252469..33264706, complement)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene beta-1,4-galactosyltransferase 1 Neighboring gene B4GALT1 antisense RNA 1 Neighboring gene RNA, U4atac small nuclear 15, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28287 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:33233401-33234600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28288 Neighboring gene serine peptidase inhibitor Kazal type 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28289 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28290 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19833 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28291 Neighboring gene charged multivesicular body protein 5 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:33288443-33289404

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat upregulates the expression of BAG-1 in Kaposi's sarcoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables adenyl-nucleotide exchange factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables adenyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-folding chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in chaperone cofactor-dependent protein refolding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of apoptotic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of smooth muscle cell apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein stabilization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    BAG family molecular chaperone regulator 1
    Names
    BCL2 associated athanogene 1
    BCL2-associated athanogene
    Bcl-2 associating athanogene-1 protein
    Bcl-2-binding protein
    glucocortoid receptor-associated protein RAP46
    receptor-associated protein, 46-KD

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029018.2 RefSeqGene

      Range
      5000..17237
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001172415.2NP_001165886.1  BAG family molecular chaperone regulator 1 isoform BAG-1S

      Status: REVIEWED

      Description
      Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while three shorter isoforms are derived from downstream AUG start codons. The most abundant of the shorter isoforms (BAG-1S, also known as p33 or p36), which is derived from the second downstream AUG start codon, is represented in this RefSeq.
      Source sequence(s)
      AL161445, AL356472
      Consensus CDS
      CCDS55301.1
      UniProtKB/Swiss-Prot
      Q99933
      Related
      ENSP00000369026.2, ENST00000379704.7
      Conserved Domains (3) summary
      smart00213
      Location:41105
      UBQ; Ubiquitin homologues
      smart00264
      Location:131211
      BAG; BAG domains, present in regulator of Hsp70 proteins
      cl00155
      Location:29105
      UBQ; Ubiquitin-like proteins
    2. NM_001349286.2NP_001336215.1  BAG family molecular chaperone regulator 1 isoform BAG-1M

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while three shorter isoforms are derived from downstream AUG start codons. One of the shorter isoforms (BAG-1M, also known as p46), which is derived from the first downstream AUG start codon, is represented in this RefSeq.
      Source sequence(s)
      AL161445, AL356472
      UniProtKB/TrEMBL
      A0A0S2Z3K4
      Conserved Domains (3) summary
      smart00264
      Location:175255
      BAG; BAG domains, present in regulator of Hsp70 proteins
      cl00155
      Location:73149
      UBQ; Ubiquitin-like proteins
      cl26511
      Location:267
      Neuromodulin_N; Gap junction protein N-terminal region
    3. NM_001349299.2NP_001336228.1  BAG family molecular chaperone regulator 1 isoform BAG1

      Status: REVIEWED

      Description
      Transcript Variant: Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while three shorter isoforms are derived from downstream AUG start codons. A minor, shorter isoform (BAG-1, also known as p29), is derived from the third downstream AUG start codon, and is represented in this RefSeq.
      Source sequence(s)
      AL161445, AL356472
      Conserved Domains (2) summary
      smart00264
      Location:108188
      BAG; BAG domains, present in regulator of Hsp70 proteins
      cl00155
      Location:682
      UBQ; Ubiquitin-like proteins
    4. NM_004323.6NP_004314.6  BAG family molecular chaperone regulator 1 isoform BAG-1L

      Status: REVIEWED

      Description
      Transcript Variant: This transcript (1) encodes multiple isoforms due to the use of alternative translation initiation codons. The longest isoform (BAG-1L or p50) is derived from an upstream non-AUG (CUG) start codon, while three shorter isoforms are derived from downstream AUG start codons. The longest isoform (BAG-1L) is represented in this RefSeq.
      Source sequence(s)
      AL161445, AL356472
      Consensus CDS
      CCDS35004.1
      UniProtKB/Swiss-Prot
      O75315, Q14414, Q53H32, Q5VZE8, Q5VZE9, Q5VZF0, Q96TG2, Q99933, Q9Y2V4
      UniProtKB/TrEMBL
      J3QTA2
      Related
      ENSP00000489189.2, ENST00000634734.3
      Conserved Domains (3) summary
      cd01812
      Location:144220
      BAG1_N; Ubiquitin-like domain of BAG1
      smart00264
      Location:246326
      BAG; BAG domains, present in regulator of Hsp70 proteins
      cl26511
      Location:64138
      Neuromodulin_N; Gap junction protein N-terminal region

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      33252471..33264708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      33271122..33283355 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)