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    Tob2 transducer of ERBB2, 2 [ Mus musculus (house mouse) ]

    Gene ID: 57259, updated on 12-Aug-2018

    Summary

    Official Symbol
    Tob2provided by MGI
    Official Full Name
    transducer of ERBB2, 2provided by MGI
    Primary source
    MGI:MGI:1888525
    See related
    Ensembl:ENSMUSG00000048546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AV071822; mKIAA1663; 2900090N22Rik; 4930545K18Rik
    Expression
    Ubiquitous expression in adrenal adult (RPKM 33.9), thymus adult (RPKM 22.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Tob2 in Genome Data Viewer
    Location:
    15; 15 E1
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 15 NC_000081.6 (81848270..81858326, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 15 NC_000081.5 (81678700..81688756, complement)

    Chromosome 15 - NC_000081.6Genomic Context describing neighboring genes Neighboring gene thyrotroph embryonic factor Neighboring gene predicted gene 8444 Neighboring gene PHD finger protein 5A Neighboring gene aconitase 2, mitochondrial Neighboring gene polymerase (RNA) III (DNA directed) polypeptide H

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from BioSystems

    • RNA degradation, organism-specific biosystem (from KEGG)
      RNA degradation, organism-specific biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • RNA degradation, conserved biosystem (from KEGG)
      RNA degradation, conserved biosystemThe correct processing, quality control and turnover of cellular RNA molecules are critical to many aspects in the expression of genetic information. In eukaryotes, two major pathways of mRNA decay e...
    • XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystem (from WikiPathways)
      XPodNet - protein-protein interactions in the podocyte expanded by STRING, organism-specific biosystemXPodNet is a larger version of PodNet. Interactions from STRING database have been added to PodNet to build XPodNet. Hence, not all interactions found in XPodNet do necessarily have to be curated.

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    vitamin D receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    negative regulation of cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    negative regulation of osteoclast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of ossification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    protein Tob2
    Names
    transducer of erbB-2 2

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020507.3NP_065253.1  protein Tob2

      See identical proteins and their annotated locations for NP_065253.1

      Status: VALIDATED

      Source sequence(s)
      AK049766, AK143542, AV220845, CK618657, DV644744
      Consensus CDS
      CCDS27673.1
      UniProtKB/Swiss-Prot
      Q9JM55
      UniProtKB/TrEMBL
      Q543X9
      Related
      ENSMUSP00000061390.7, ENSMUST00000050467.8
      Conserved Domains (1) summary
      pfam07742
      Location:1112
      BTG; BTG family

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000081.6 Reference GRCm38.p4 C57BL/6J

      Range
      81848270..81858326 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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