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    SNX14 sorting nexin 14 [ Homo sapiens (human) ]

    Gene ID: 57231, updated on 17-Sep-2024

    Summary

    Official Symbol
    SNX14provided by HGNC
    Official Full Name
    sorting nexin 14provided by HGNC
    Primary source
    HGNC:HGNC:14977
    See related
    Ensembl:ENSG00000135317 MIM:616105; AllianceGenome:HGNC:14977
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SCAR20; RGS-PX2
    Summary
    This gene encodes a member of the sorting nexin family. Members of this family have a phox (PX) phosphoinositide binding domain and are involved in intracellular trafficking. The encoded protein also contains a regulator of G protein signaling (RGS) domain. Regulator of G protein signaling family members are regulatory molecules that act as GTPase activating proteins for G alpha subunits of heterotrimeric G proteins. Alternate splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2014]
    Expression
    Ubiquitous expression in testis (RPKM 30.0), thyroid (RPKM 16.2) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SNX14 in Genome Data Viewer
    Location:
    6q14.3
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (85505496..85593858, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (86722300..86810666, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (86215214..86303576, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene TPT1 pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17366 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24787 Neighboring gene 5'-nucleotidase ecto Neighboring gene ReSE screen-validated silencer GRCh37_chr6:86210956-86211197 Neighboring gene Sharpr-MPRA regulatory region 13581 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86263391-86263890 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86262889-86263390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:86302067-86302652 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:86302653-86303236 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:86303237-86303820 Neighboring gene synaptotagmin binding cytoplasmic RNA interacting protein Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17368 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17369 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17370 Neighboring gene pyruvate kinase M1/2 pseudogene 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC13217

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables phosphatidylinositol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol-3,5-bisphosphate binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in autophagosome maturation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in autophagosome maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in postsynaptic modulation of chemical synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    is_active_in late endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in late endosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in late endosome membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynapse IEA
    Inferred from Electronic Annotation
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_047171.1 RefSeqGene

      Range
      5299..93661
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001297614.3NP_001284543.1  sorting nexin-14 isoform c

      See identical proteins and their annotated locations for NP_001284543.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an in-frame segment of the coding region compared to variant 1. It encodes a shorter isoform (c), compared to isoform a.
      Source sequence(s)
      BC005110, BC046520, CB054302, DA491624
      Consensus CDS
      CCDS75490.1
      UniProtKB/TrEMBL
      D6RJG9
      Related
      ENSP00000358641.2, ENST00000369627.6
      Conserved Domains (4) summary
      cd06877
      Location:555677
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:340466
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:130299
      PXA; PXA domain
      pfam08628
      Location:798902
      Nexin_C; Sorting nexin C terminal
    2. NM_001304479.2NP_001291408.1  sorting nexin-14 isoform d

      See identical proteins and their annotated locations for NP_001291408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and uses a downstream in-frame start codon, compared to variant 1. The encoded isoform (d) has a shorter N-terminus compared to isoform a.
      Source sequence(s)
      AK295417, CB054302
      Consensus CDS
      CCDS78163.1
      UniProtKB/TrEMBL
      D6RJG9
      Related
      ENSP00000427380.1, ENST00000505648.5
      Conserved Domains (4) summary
      cd06877
      Location:512634
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:288414
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:78247
      PXA; PXA domain
      pfam08628
      Location:755859
      Nexin_C; Sorting nexin C terminal
    3. NM_001350532.2NP_001337461.1  sorting nexin-14 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (e).
      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93964.1
      UniProtKB/TrEMBL
      A0A804HKZ1, D6RJG9
      Related
      ENSP00000508127.1, ENST00000684570.1
      Conserved Domains (4) summary
      cd06877
      Location:585707
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:361487
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:151320
      PXA; PXA domain
      pfam08628
      Location:828932
      Nexin_C; Sorting nexin C terminal
    4. NM_001350533.2NP_001337462.1  sorting nexin-14 isoform f

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93960.1
      UniProtKB/TrEMBL
      A0A804HIK6, A0A804HKC6, D6RJG9
      Related
      ENSP00000507869.1, ENST00000682497.1
      Conserved Domains (4) summary
      cd06877
      Location:563685
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:339465
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:129298
      PXA; PXA domain
      pfam08628
      Location:806910
      Nexin_C; Sorting nexin C terminal
    5. NM_001350534.2NP_001337463.1  sorting nexin-14 isoform g

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      UniProtKB/TrEMBL
      A0A804HIK6, D6RJG9
      Conserved Domains (4) summary
      cd06877
      Location:554676
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:339465
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:129298
      PXA; PXA domain
      pfam08628
      Location:797901
      Nexin_C; Sorting nexin C terminal
    6. NM_001350535.2NP_001337464.1  sorting nexin-14 isoform h

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93959.1
      UniProtKB/TrEMBL
      A0A804HKJ3, D6RJG9
      Related
      ENSP00000507950.1, ENST00000684118.1
      Conserved Domains (4) summary
      cd06877
      Location:563685
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:339465
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:129298
      PXA; PXA domain
      pfam08628
      Location:806910
      Nexin_C; Sorting nexin C terminal
    7. NM_001350536.2NP_001337465.1  sorting nexin-14 isoform i

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93961.1
      UniProtKB/TrEMBL
      A0A804HI47, A0A804HJC6
      Related
      ENSP00000507444.1, ENST00000683643.1
      Conserved Domains (4) summary
      cd06877
      Location:520642
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:296422
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:137255
      PXA; PXA domain
      pfam08628
      Location:763867
      Nexin_C; Sorting nexin C terminal
    8. NM_001350537.2NP_001337466.1  sorting nexin-14 isoform j

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93958.1
      UniProtKB/TrEMBL
      A0A804HI47, A0A804HIR3
      Related
      ENSP00000507188.1, ENST00000683785.1
      Conserved Domains (4) summary
      cd06877
      Location:519641
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:295421
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:136254
      PXA; PXA domain
      pfam08628
      Location:762866
      Nexin_C; Sorting nexin C terminal
    9. NM_001350538.2NP_001337467.1  sorting nexin-14 isoform k

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      UniProtKB/TrEMBL
      D6RJG9
      Conserved Domains (4) summary
      cd06877
      Location:516638
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:292418
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:130251
      PXA; PXA domain
      pfam08628
      Location:759863
      Nexin_C; Sorting nexin C terminal
    10. NM_001350539.2NP_001337468.1  sorting nexin-14 isoform l

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93956.1
      UniProtKB/TrEMBL
      A0A804HIK6, A0A804HJ91, D6RJG9
      Related
      ENSP00000508327.1, ENST00000682171.1
      Conserved Domains (4) summary
      cd06877
      Location:511633
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:287413
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:77246
      PXA; PXA domain
      pfam08628
      Location:754858
      Nexin_C; Sorting nexin C terminal
    11. NM_001350540.2NP_001337469.1  sorting nexin-14 isoform m

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93963.1
      UniProtKB/TrEMBL
      A0A804HJK3, A0A804HK55
      Related
      ENSP00000507777.1, ENST00000682682.1
      Conserved Domains (4) summary
      cd06877
      Location:564686
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:340466
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:130299
      PXA; PXA domain
      pfam08628
      Location:778856
      Nexin_C; Sorting nexin C terminal
    12. NM_001350541.2NP_001337470.1  sorting nexin-14 isoform n

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93962.1
      UniProtKB/TrEMBL
      A0A804HJK3, A0A804HK22
      Related
      ENSP00000507742.1, ENST00000682738.1
      Conserved Domains (4) summary
      cd06877
      Location:555677
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:340466
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:130299
      PXA; PXA domain
      pfam08628
      Location:769847
      Nexin_C; Sorting nexin C terminal
    13. NM_001350542.2NP_001337471.1  sorting nexin-14 isoform o

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93957.1
      UniProtKB/TrEMBL
      A0A804HI47, A0A804HIA1
      Related
      ENSP00000506970.1, ENST00000682491.1
      Conserved Domains (4) summary
      cd06877
      Location:468590
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:244370
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:85203
      PXA; PXA domain
      pfam08628
      Location:711815
      Nexin_C; Sorting nexin C terminal
    14. NM_001350543.2NP_001337472.1  sorting nexin-14 isoform p

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Consensus CDS
      CCDS93955.1
      UniProtKB/TrEMBL
      A0A804HI30, A0A804HIK6, D6RJG9
      Related
      ENSP00000506873.1, ENST00000684647.1
      Conserved Domains (4) summary
      cd06877
      Location:467589
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:243369
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:84202
      PXA; PXA domain
      pfam08628
      Location:710814
      Nexin_C; Sorting nexin C terminal
    15. NM_001350544.2NP_001337473.1  sorting nexin-14 isoform q

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      UniProtKB/TrEMBL
      D6RJG9
      Conserved Domains (4) summary
      cd06877
      Location:464586
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:240366
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:78199
      PXA; PXA domain
      pfam08628
      Location:707811
      Nexin_C; Sorting nexin C terminal
    16. NM_001350545.2NP_001337474.1  sorting nexin-14 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18), as well as variant 19, encodes isoform r.
      Source sequence(s)
      AL136082, AL589666
      UniProtKB/TrEMBL
      A0A804HI51
      Conserved Domains (4) summary
      cd06877
      Location:416538
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:192318
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:6151
      PXA; PXA domain
      pfam08628
      Location:659763
      Nexin_C; Sorting nexin C terminal
    17. NM_001350546.2NP_001337475.1  sorting nexin-14 isoform r

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19), as well as variant 18, encodes isoform r.
      Source sequence(s)
      AL136082, AL589666
      UniProtKB/TrEMBL
      A0A804HI51
      Conserved Domains (4) summary
      cd06877
      Location:416538
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:192318
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:6151
      PXA; PXA domain
      pfam08628
      Location:659763
      Nexin_C; Sorting nexin C terminal
    18. NM_001350547.2NP_001337476.1  sorting nexin-14 isoform s

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Conserved Domains (3) summary
      cd06877
      Location:214336
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:1116
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam08628
      Location:457561
      Nexin_C; Sorting nexin C terminal
    19. NM_001350548.2NP_001337477.1  sorting nexin-14 isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21), as well as variants 22-25, encodes isoform t.
      Source sequence(s)
      AL136082, AL589666
      Conserved Domains (3) summary
      cd06877
      Location:179301
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      pfam08628
      Location:422526
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:181
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    20. NM_001350549.2NP_001337478.1  sorting nexin-14 isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (22), as well as variants 21 and 23-25, encodes isoform t.
      Source sequence(s)
      AL136082, AL589666
      Conserved Domains (3) summary
      cd06877
      Location:179301
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      pfam08628
      Location:422526
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:181
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    21. NM_001350550.2NP_001337479.1  sorting nexin-14 isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (23), as well as variants 21, 22, 24, and 25, encodes isoform t.
      Source sequence(s)
      AL136082, AL589666
      Conserved Domains (3) summary
      cd06877
      Location:179301
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      pfam08628
      Location:422526
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:181
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    22. NM_001350551.2NP_001337480.1  sorting nexin-14 isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (24), as well as variants 21-23 and 25, encodes isoform t.
      Source sequence(s)
      AL136082, AL589666
      Conserved Domains (3) summary
      cd06877
      Location:179301
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      pfam08628
      Location:422526
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:181
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    23. NM_001350552.2NP_001337481.1  sorting nexin-14 isoform t

      Status: REVIEWED

      Description
      Transcript Variant: This variant (25), as well as variants 21-24, encodes isoform t.
      Source sequence(s)
      AL136082, AL589666
      Conserved Domains (3) summary
      cd06877
      Location:179301
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      pfam08628
      Location:422526
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:181
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    24. NM_001350553.2NP_001337482.1  sorting nexin-14 isoform u

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Conserved Domains (3) summary
      cd06877
      Location:170292
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      pfam08628
      Location:413517
      Nexin_C; Sorting nexin C terminal
      cl02565
      Location:181
      RGS; Regulator of G protein signaling (RGS) domain superfamily
    25. NM_020468.6NP_065201.1  sorting nexin-14 isoform b

      See identical proteins and their annotated locations for NP_065201.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks in-frame segments of the coding region compared to variant 1. It encodes a shorter isoform (b), compared to isoform a.
      Source sequence(s)
      BC005110, CB054302
      Consensus CDS
      CCDS5003.1
      UniProtKB/TrEMBL
      A0A804HI47
      Related
      ENSP00000257769.3, ENST00000346348.7
      Conserved Domains (4) summary
      cd06877
      Location:511633
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:296422
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:137255
      PXA; PXA domain
      pfam08628
      Location:754858
      Nexin_C; Sorting nexin C terminal
    26. NM_153816.6NP_722523.1  sorting nexin-14 isoform a

      See identical proteins and their annotated locations for NP_722523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      BC005110, BC095419, CB054302, DA491624
      Consensus CDS
      CCDS5004.1
      UniProtKB/Swiss-Prot
      B4DI55, Q4VBR3, Q5TCF9, Q5TCG0, Q6NUI7, Q6PI37, Q9BSD1, Q9Y5W7
      UniProtKB/TrEMBL
      D6RJG9
      Related
      ENSP00000313121.3, ENST00000314673.8
      Conserved Domains (4) summary
      cd06877
      Location:564686
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:340466
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:130299
      PXA; PXA domain
      pfam08628
      Location:807911
      Nexin_C; Sorting nexin C terminal

    RNA

    1. NR_146774.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Related
      ENST00000682633.1
    2. NR_146775.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Related
      ENST00000684299.1
    3. NR_146776.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Related
      ENST00000683577.1
    4. NR_146777.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Related
      ENST00000682688.1
    5. NR_146778.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Related
      ENST00000684319.1
    6. NR_146779.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL136082, AL589666
      Related
      ENST00000682133.1

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      85505496..85593858 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419128.1XP_047275084.1  sorting nexin-14 isoform X10

      UniProtKB/TrEMBL
      A0A804HJG1
    2. XM_047419127.1XP_047275083.1  sorting nexin-14 isoform X9

      UniProtKB/TrEMBL
      A0A804HI47
    3. XM_047419123.1XP_047275079.1  sorting nexin-14 isoform X5

      UniProtKB/TrEMBL
      A0A804HJG1
      Related
      ENSP00000507491.1, ENST00000684680.1
    4. XM_047419121.1XP_047275077.1  sorting nexin-14 isoform X4

      UniProtKB/TrEMBL
      A0A804HI47
    5. XM_047419120.1XP_047275076.1  sorting nexin-14 isoform X2

      UniProtKB/TrEMBL
      D6RJG9
    6. XM_047419129.1XP_047275085.1  sorting nexin-14 isoform X10

      UniProtKB/TrEMBL
      A0A804HJG1
    7. XM_047419124.1XP_047275080.1  sorting nexin-14 isoform X6

      UniProtKB/TrEMBL
      A0A804HJG1
    8. XM_017011090.2XP_016866579.1  sorting nexin-14 isoform X3

      UniProtKB/TrEMBL
      A0A804HIK6, A0A804HJ91, D6RJG9
      Related
      ENSP00000507401.1, ENST00000684150.1
      Conserved Domains (4) summary
      cd06877
      Location:511633
      PX_SNX14; The phosphoinositide binding Phox Homology domain of Sorting Nexin 14
      cd08722
      Location:287413
      RGS_SNX14; Regulator of G protein signaling (RGS) domain found in the Sorting Nexin14 (SNX14) protein
      pfam02194
      Location:77246
      PXA; PXA domain
      pfam08628
      Location:754858
      Nexin_C; Sorting nexin C terminal
    9. XM_047419126.1XP_047275082.1  sorting nexin-14 isoform X8

      UniProtKB/TrEMBL
      A0A804HI47, A0A804HIA1
    10. XM_047419122.1XP_047275078.1  sorting nexin-14 isoform X5

      UniProtKB/TrEMBL
      A0A804HJG1
    11. XM_047419125.1XP_047275081.1  sorting nexin-14 isoform X7

      UniProtKB/TrEMBL
      A0A804HJS3
      Related
      ENSP00000507625.1, ENST00000682464.1
    12. XM_011535977.3XP_011534279.2  sorting nexin-14 isoform X1

      UniProtKB/TrEMBL
      A0A804HJS3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      86722300..86810666 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356027.1XP_054212002.1  sorting nexin-14 isoform X10

      UniProtKB/TrEMBL
      A0A804HJG1
    2. XM_054356026.1XP_054212001.1  sorting nexin-14 isoform X9

      UniProtKB/TrEMBL
      A0A804HI47
    3. XM_054356022.1XP_054211997.1  sorting nexin-14 isoform X5

      UniProtKB/TrEMBL
      A0A804HJG1
    4. XM_054356020.1XP_054211995.1  sorting nexin-14 isoform X4

      UniProtKB/TrEMBL
      A0A804HI47
    5. XM_054356018.1XP_054211993.1  sorting nexin-14 isoform X2

      UniProtKB/TrEMBL
      D6RJG9
    6. XM_054356028.1XP_054212003.1  sorting nexin-14 isoform X10

      UniProtKB/TrEMBL
      A0A804HJG1
    7. XM_054356023.1XP_054211998.1  sorting nexin-14 isoform X6

      UniProtKB/TrEMBL
      A0A804HJG1
    8. XM_054356019.1XP_054211994.1  sorting nexin-14 isoform X3

      UniProtKB/TrEMBL
      A0A804HIK6, D6RJG9
    9. XM_054356025.1XP_054212000.1  sorting nexin-14 isoform X8

      UniProtKB/TrEMBL
      A0A804HI47
    10. XM_054356021.1XP_054211996.1  sorting nexin-14 isoform X5

      UniProtKB/TrEMBL
      A0A804HJG1
    11. XM_054356024.1XP_054211999.1  sorting nexin-14 isoform X7

      UniProtKB/TrEMBL
      A0A804HJS3
    12. XM_054356017.1XP_054211992.1  sorting nexin-14 isoform X1

      UniProtKB/TrEMBL
      A0A804HJS3