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    THOC2 THO complex subunit 2 [ Homo sapiens (human) ]

    Gene ID: 57187, updated on 17-Jun-2024

    Summary

    Official Symbol
    THOC2provided by HGNC
    Official Full Name
    THO complex subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:19073
    See related
    Ensembl:ENSG00000125676 MIM:300395; AllianceGenome:HGNC:19073
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    THO2; MRX12; MRX35; CXorf3; XLID12; hTREX120; dJ506G2.1
    Summary
    The TREX multiprotein complex binds specifically to spliced mRNAs to facilitate mRNA export. The protein encoded by this gene is a member of the THO complex, a subset of the TREX complex. The encoded protein interacts with the THOC1 protein.[provided by RefSeq, Jun 2010]
    Expression
    Ubiquitous expression in lymph node (RPKM 8.1), thyroid (RPKM 7.3) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See THOC2 in Genome Data Viewer
    Location:
    Xq25
    Exon count:
    41
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (123600569..123733052, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (121911026..122043503, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (122734420..122866902, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene cytochrome c oxidase subunit NDUFA4-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:122695822-122696322 Neighboring gene tubulin beta 4A class IVa pseudogene 1 Neighboring gene FER tyrosine kinase pseudogene 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:122781620-122782478 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:122782479-122783335 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chrX:122813879-122814524 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29909 Neighboring gene RNA, U7 small nuclear 69 pseudogene Neighboring gene MEMO1 pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of THO complex 2 (THOC2) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify THO complex 2 protein (THOC2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify THO complex 2 protein (THOC2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Nef nef Tandem affinity purification and mass spectrometry analysis identify THO complex 2 protein (THOC2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
    Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify THO complex 2 protein (THOC2), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in blastocyst development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in generation of neurons IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neuron projection development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in neuron development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in poly(A)+ mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of mRNA export from nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell division IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of THO complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of THO complex part of transcription export complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    colocalizes_with chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of transcription export complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    THO complex subunit 2
    Names
    THO complex 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021468.2 RefSeqGene

      Range
      5000..137483
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001081550.2NP_001075019.1  THO complex subunit 2

      See identical proteins and their annotated locations for NP_001075019.1

      Status: REVIEWED

      Source sequence(s)
      AF441770, AW206982, BC054050, DA504931
      Consensus CDS
      CCDS43988.1
      UniProtKB/Swiss-Prot
      A6NM50, Q5JZ12, Q6IN92, Q8NI27, Q9H8I6
      UniProtKB/TrEMBL
      A0A0C4DG98
      Related
      ENSP00000245838.8, ENST00000245838.13
      Conserved Domains (5) summary
      PTZ00121
      Location:12911593
      PTZ00121; MAEBL; Provisional
      TIGR01642
      Location:14481556
      U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor
      pfam11262
      Location:8741173
      Tho2; Transcription factor/nuclear export subunit protein 2
      pfam11732
      Location:568642
      Thoc2; Transcription- and export-related complex subunit
      pfam16134
      Location:11566
      THOC2_N; THO complex subunit 2 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      123600569..123733052 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047442276.1XP_047298232.1  THO complex subunit 2 isoform X10

      UniProtKB/Swiss-Prot
      A6NM50, Q5JZ12, Q6IN92, Q8NI27, Q9H8I6
      UniProtKB/TrEMBL
      A0A0C4DG98
    2. XM_047442270.1XP_047298226.1  THO complex subunit 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG98
    3. XM_047442273.1XP_047298229.1  THO complex subunit 2 isoform X7

      UniProtKB/TrEMBL
      A0A0C4DG98
    4. XM_047442267.1XP_047298223.1  THO complex subunit 2 isoform X3

      UniProtKB/TrEMBL
      A0A0C4DG98
    5. XM_017029679.2XP_016885168.1  THO complex subunit 2 isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG98
    6. XM_047442274.1XP_047298230.1  THO complex subunit 2 isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG98
    7. XM_047442268.1XP_047298224.1  THO complex subunit 2 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DG98
    8. XM_047442269.1XP_047298225.1  THO complex subunit 2 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DG98
    9. XM_047442271.1XP_047298227.1  THO complex subunit 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG98
    10. XM_047442272.1XP_047298228.1  THO complex subunit 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG98
    11. XM_047442265.1XP_047298221.1  THO complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG98
    12. XM_047442266.1XP_047298222.1  THO complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG98
    13. XM_047442263.1XP_047298219.1  THO complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0C4DG98
    14. XM_047442264.1XP_047298220.1  THO complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0C4DG98
    15. XM_047442278.1XP_047298234.1  THO complex subunit 2 isoform X12

      UniProtKB/TrEMBL
      A0A0C4DG98
    16. XM_047442277.1XP_047298233.1  THO complex subunit 2 isoform X11

      UniProtKB/TrEMBL
      A0A0C4DG98
    17. XM_047442275.1XP_047298231.1  THO complex subunit 2 isoform X9

      UniProtKB/TrEMBL
      A0A0C4DG98

    RNA

    1. XR_007068195.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      121911026..122043503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054327431.1XP_054183406.1  THO complex subunit 2 isoform X10

      UniProtKB/Swiss-Prot
      A6NM50, Q5JZ12, Q6IN92, Q8NI27, Q9H8I6
      UniProtKB/TrEMBL
      A0A0C4DG98
    2. XM_054327424.1XP_054183399.1  THO complex subunit 2 isoform X5

      UniProtKB/TrEMBL
      A0A0C4DG98
    3. XM_054327427.1XP_054183402.1  THO complex subunit 2 isoform X7

      UniProtKB/TrEMBL
      A0A0C4DG98
    4. XM_054327421.1XP_054183396.1  THO complex subunit 2 isoform X3

      UniProtKB/TrEMBL
      A0A0C4DG98
    5. XM_054327428.1XP_054183403.1  THO complex subunit 2 isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG98
    6. XM_054327429.1XP_054183404.1  THO complex subunit 2 isoform X8

      UniProtKB/TrEMBL
      A0A0C4DG98
    7. XM_054327422.1XP_054183397.1  THO complex subunit 2 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DG98
    8. XM_054327423.1XP_054183398.1  THO complex subunit 2 isoform X4

      UniProtKB/TrEMBL
      A0A0C4DG98
    9. XM_054327425.1XP_054183400.1  THO complex subunit 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG98
    10. XM_054327426.1XP_054183401.1  THO complex subunit 2 isoform X6

      UniProtKB/TrEMBL
      A0A0C4DG98
    11. XM_054327419.1XP_054183394.1  THO complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG98
    12. XM_054327420.1XP_054183395.1  THO complex subunit 2 isoform X2

      UniProtKB/TrEMBL
      A0A0C4DG98
    13. XM_054327417.1XP_054183392.1  THO complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0C4DG98
    14. XM_054327418.1XP_054183393.1  THO complex subunit 2 isoform X1

      UniProtKB/TrEMBL
      A0A0C4DG98
    15. XM_054327433.1XP_054183408.1  THO complex subunit 2 isoform X12

      UniProtKB/TrEMBL
      A0A0C4DG98
    16. XM_054327432.1XP_054183407.1  THO complex subunit 2 isoform X11

      UniProtKB/TrEMBL
      A0A0C4DG98
    17. XM_054327430.1XP_054183405.1  THO complex subunit 2 isoform X9

      UniProtKB/TrEMBL
      A0A0C4DG98

    RNA

    1. XR_008485497.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_020449.2: Suppressed sequence

      Description
      NM_020449.2: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.