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    LYRM4 LYR motif containing 4 [ Homo sapiens (human) ]

    Gene ID: 57128, updated on 8-Jul-2021

    Summary

    Official Symbol
    LYRM4provided by HGNC
    Official Full Name
    LYR motif containing 4provided by HGNC
    Primary source
    HGNC:HGNC:21365
    See related
    Ensembl:ENSG00000214113 MIM:613311
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ISD11; CGI-203; COXPD19; C6orf149
    Summary
    The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016]
    Expression
    Ubiquitous expression in ovary (RPKM 2.3), thyroid (RPKM 2.1) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See LYRM4 in Genome Data Viewer
    Location:
    6p25.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    109.20210514 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (5031029..5260950, complement)
    105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (5068561..5261183, complement)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ribosomal protein S18 pseudogene 8 Neighboring gene LYRM4 antisense RNA 1 Neighboring gene ribonuclease P/MRP subunit p40 Neighboring gene transcription factor B2, mitochondrial pseudogene Neighboring gene protein phosphatase 1 regulatory subunit 3G Neighboring gene microRNA 3691 Neighboring gene Sharpr-MPRA regulatory region 4425 Neighboring gene phenylalanyl-tRNA synthetase 2, mitochondrial Neighboring gene uncharacterized LOC101927972

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    A genome-wide search for common SNP x SNP interactions on the risk of venous thrombosis.
    GeneReviews: Not available
    Combined oxidative phosphorylation deficiency 19
    MedGen: C3810055 OMIM: 615595 GeneReviews: Not available
    Compare labs
    Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.
    GeneReviews: Not available

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in iron-sulfur cluster assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of L-cysteine desulfurase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial matrix TAS
    Traceable Author Statement
    more info
     
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     

    General protein information

    Preferred Names
    LYR motif-containing protein 4
    Names
    homolog of yeast Isd11
    mitochondrial matrix Nfs1 interacting protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051651.1 RefSeqGene

      Range
      5001..157532
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001164840.3NP_001158312.1  LYR motif-containing protein 4 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a distinct, longer C-terminus compared to isoform 1.
      Source sequence(s)
      CK819966, HY168919
      Consensus CDS
      CCDS54962.1
      UniProtKB/TrEMBL
      F5H189
      Related
      ENSP00000443900.3, ENST00000500576.4
      Conserved Domains (2) summary
      pfam13232
      Location:767
      Complex1_LYR_1; Complex1_LYR-like
      pfam13900
      Location:75122
      GVQW; Putative domain of unknown function
    2. NM_001164841.3NP_001158313.1  LYR motif-containing protein 4 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an additional exon that results in an alternate 3' coding region and 3' UTR compared to variant 1. The encoded isoform (3) has a distinct, longer C-terminus compared to isoform 1.
      Source sequence(s)
      AF170070, AL035653, BC067762, BX353584, CA310019, HY168919
      Consensus CDS
      CCDS54961.1
      UniProtKB/Swiss-Prot
      Q9HD34
      UniProtKB/TrEMBL
      C9JRX8
      Related
      ENSP00000420026.1, ENST00000464010.5
      Conserved Domains (1) summary
      pfam13232
      Location:767
      Complex1_LYR_1; Complex1_LYR-like
    3. NM_001318782.1NP_001305711.1  LYR motif-containing protein 4 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) contains an alternate 3' coding region and 3' UTR compared to variant 1. The encoded isoform (4) has a distinct, shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AK309661, AL035653, HY168919
      Consensus CDS
      CCDS83061.1
      UniProtKB/TrEMBL
      C9JY28
      Related
      ENSP00000419928.1, ENST00000480566.5
      Conserved Domains (1) summary
      pfam13232
      Location:767
      Complex1_LYR_1; Complex1_LYR-like
    4. NM_001318783.1NP_001305712.1  LYR motif-containing protein 4 isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) contains an alternate 3' coding region and 3' UTR compared to variant 1. The encoded isoform (5) has a distinct, longer C-terminus compared to isoform 1.
      Source sequence(s)
      AL121978, DA114665, HY168919
      Conserved Domains (1) summary
      pfam13232
      Location:767
      Complex1_LYR_1; Complex1_LYR-like
    5. NM_020408.6NP_065141.3  LYR motif-containing protein 4 isoform 1

      See identical proteins and their annotated locations for NP_065141.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AF170070, AL035653, BC067762, CA310019, HY168919
      Consensus CDS
      CCDS4493.1
      UniProtKB/Swiss-Prot
      Q9HD34
      Related
      ENSP00000418787.1, ENST00000330636.9
      Conserved Domains (1) summary
      pfam13232
      Location:767
      Complex1_LYR_1; Complex1_LYR-like

    RNA

    1. NR_104417.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) contains an additional exon in the 3' region compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AF170070, AK309458, AL035653, BC067762, CA310019, HY168919
      Related
      ENST00000463032.5
    2. NR_104418.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AF170070, AL035653, BC067762, CA310019, HY168919
      Related
      ENST00000468929.5
    3. NR_134856.1 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an exon and contains two alternate 3' exons compared to variant 1. This variant is represented as non-coding because use of the expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      DA114665, DA222333, HY168919

    RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p13 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

      Range
      5031029..5260950 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011084.2XP_016866573.1  LYR motif-containing protein 4 isoform X1

    2. XM_017011083.2XP_016866572.1  LYR motif-containing protein 4 isoform X2

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