U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination
    • Showing Current items.

    PSMB5 proteasome 20S subunit beta 5 [ Homo sapiens (human) ]

    Gene ID: 5693, updated on 17-Jun-2024

    Summary

    Official Symbol
    PSMB5provided by HGNC
    Official Full Name
    proteasome 20S subunit beta 5provided by HGNC
    Primary source
    HGNC:HGNC:9542
    See related
    Ensembl:ENSG00000100804 MIM:600306; AllianceGenome:HGNC:9542
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MB1; LMPX
    Summary
    The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit in the proteasome. This catalytic subunit is not present in the immunoproteasome and is replaced by catalytic subunit 3i (proteasome beta 8 subunit). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
    Expression
    Ubiquitous expression in brain (RPKM 31.9), placenta (RPKM 30.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PSMB5 in Genome Data Viewer
    Location:
    14q11.2
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (23025851..23035220, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (17226471..17235840, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (23495060..23504429, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5597 Neighboring gene AJUBA divergent transcript Neighboring gene chromosome 14 open reading frame 93 Neighboring gene uncharacterized LOC124903286 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5598 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:23477153-23477713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8157 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:23503835-23505034 Neighboring gene proteasome subunit beta 11 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:23521379-23521879 Neighboring gene cadherin 24 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5600

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat slightly enhances the activity of the purified 26 S proteasome PubMed
    tat Amino acids Lys51, Arg52, and Asp67 of HIV-1 Tat represent the proteasome binding site of Tat, and Tat amino acids 37-72 are necessary for proteasomal interaction and suppression of 11 S regulator-mediated antigen presentation PubMed
    tat HIV-1 Tat inhibits the peptidase activity of the 20 S proteasome and interferes with the formation of the 20 S proteasome-11 S regulator complex PubMed
    tat HIV-1 Tat binds to the alpha2, alpha4, alpha6, alpha7, beta1, beta2, beta3, beta5, beta6, beta7, LMP7/beta5i, and MECL1/beta2i subunits of the proteasome 20 S core structure and can inhibit cellular proteasome function PubMed
    Vif vif HIV-1 Vif binds to the cellular cytidine deaminase APOBEC3G and targets it for degradation through an interaction with the proteasome, thereby inhibiting APOBEC3G mediated restriction of HIV-1 replication PubMed
    integrase gag-pol Proteasomal degradation of HIV-1 integrase in mammalian cells occurs by the N-end rule pathway PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC104214

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables endopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables peptidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables threonine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of proteasome core complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of proteasome core complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of proteasome core complex, beta-subunit complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of proteasome core complex, beta-subunit complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    proteasome subunit beta type-5
    Names
    PSX large multifunctional protease X
    macropain epsilon chain
    multicatalytic endopeptidase complex epsilon chain
    proteasome (prosome, macropain) subunit, beta type, 5
    proteasome beta 5 subunit
    proteasome catalytic subunit 3
    proteasome chain 6
    proteasome epsilon chain
    proteasome subunit MB1
    proteasome subunit X
    proteasome subunit beta 5
    proteasome subunit, beta type, 5
    testicular tissue protein Li 153
    NP_001124197.1
    NP_001138404.1
    NP_002788.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001130725.1NP_001124197.1  proteasome subunit beta type-5 isoform 2

      See identical proteins and their annotated locations for NP_001124197.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses a different segment for its 5' UTR and lacks the 5' end of the coding region, compared to variant 1. The encoded protein (isoform 2) results from the use of a downstream start codon and is shorter when it is compared to isoform 1.
      Source sequence(s)
      BC107720, BU539357, BU632351, CD048996
      Consensus CDS
      CCDS45083.1
      UniProtKB/TrEMBL
      A0A140VJS7
      Related
      ENSP00000395206.2, ENST00000425762.2
      Conserved Domains (1) summary
      cd03761
      Location:1144
      proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
    2. NM_001144932.3NP_001138404.1  proteasome subunit beta type-5 isoform 3

      See identical proteins and their annotated locations for NP_001138404.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) includes an alternate exon, compared to variant 1, that causes a frameshift. The resulting protein (isoform 3) has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL132780, KF455837
      Consensus CDS
      CCDS45084.1
      UniProtKB/Swiss-Prot
      P28074
      Related
      ENSP00000452424.1, ENST00000493471.2
      Conserved Domains (1) summary
      cl00467
      Location:60168
      Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
    3. NM_002797.5NP_002788.1  proteasome subunit beta type-5 isoform 1

      See identical proteins and their annotated locations for NP_002788.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longest protein (isoform 1).
      Source sequence(s)
      BC057840, BC107720
      Consensus CDS
      CCDS9584.1
      UniProtKB/Swiss-Prot
      B2R4N9, B4DUM9, D3DS43, E9PAV2, P28074, Q16242, Q6PEW2, Q7Z3B5, Q86T01, Q9TNN9
      Related
      ENSP00000355325.6, ENST00000361611.11
      Conserved Domains (1) summary
      cd03761
      Location:60247
      proteasome_beta_type_5; proteasome beta type-5 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      23025851..23035220 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      17226471..17235840 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)