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    Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 [ Mus musculus (house mouse) ]

    Gene ID: 56812, updated on 9-Sep-2018

    Summary

    Official Symbol
    Dnajb2provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B2provided by MGI
    Primary source
    MGI:MGI:1928739
    See related
    Ensembl:ENSMUSG00000026203 Vega:OTTMUSG00000048595
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsj1; mDj8; Dnajb10; 2700059H22Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 63.8), cerebellum adult (RPKM 25.3) and 28 other tissues See more
    Orthologs

    Genomic context

    See Dnajb2 in Genome Data Viewer
    Location:
    1; 1 C4
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 1 NC_000067.6 (75236403..75245692)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (75232998..75242267)

    Chromosome 1 - NC_000067.6Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 16 Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene tubulin, alpha 4A Neighboring gene protein tyrosine phosphatase, receptor type, N Neighboring gene regulated endocrine-specific protein 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from BioSystems

    • Protein processing in endoplasmic reticulum, organism-specific biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, organism-specific biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...
    • Protein processing in endoplasmic reticulum, conserved biosystem (from KEGG)
      Protein processing in endoplasmic reticulum, conserved biosystemThe endoplasmic reticulum (ER) is a subcellular organelle where proteins are folded with the help of lumenal chaperones. Newly synthesized peptides enter the ER via the sec61 pore and are glycosylate...

    General gene information

    Homology

    Clone Names

    • MGC113758

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of cell proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    negative regulation of protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    intrinsic component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    intrinsic component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    membrane IEA
    Inferred from Electronic Annotation
    more info
     
    nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    colocalizes_with proteasome complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    colocalizes_with proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 2
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 10
    DnaJ (Hsp40) homolog, subfamily B, member 2
    dnaJ homolog subfamily B member 10
    heat shock protein, DNAJ-like 1

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159883.1NP_001153355.1  dnaJ homolog subfamily B member 2 isoform 3

      See identical proteins and their annotated locations for NP_001153355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AK171494, BF467509, BY073498
      Consensus CDS
      CCDS78622.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000140566.1, OTTMUSP00000067716, ENSMUST00000188931.6, OTTMUST00000124478
      Conserved Domains (1) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    2. NM_001159884.1NP_001153356.1  dnaJ homolog subfamily B member 2 isoform 2

      See identical proteins and their annotated locations for NP_001153356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.
      Source sequence(s)
      AK076061, BF467509, BY073498, BY092620
      Consensus CDS
      CCDS35624.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000140588.1, OTTMUSP00000067717, ENSMUST00000188346.6, OTTMUST00000124480
      Conserved Domains (3) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
      pfam02809
      Location:250266
      UIM; Ubiquitin interaction motif
    3. NM_001159885.1NP_001153357.1  dnaJ homolog subfamily B member 2 isoform 2

      See identical proteins and their annotated locations for NP_001153357.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.
      Source sequence(s)
      AK076061, BF467509, CJ174452
      Consensus CDS
      CCDS35624.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000080796.6, ENSMUST00000082158.12
      Conserved Domains (3) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
      pfam02809
      Location:250266
      UIM; Ubiquitin interaction motif
    4. NM_020266.2NP_064662.2  dnaJ homolog subfamily B member 2 isoform 1

      See identical proteins and their annotated locations for NP_064662.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (1) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AB028858, AK076061, BF467509, BY073498
      Consensus CDS
      CCDS15068.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000140637.1, OTTMUSP00000067720, ENSMUST00000187058.6, OTTMUST00000124483
      Conserved Domains (3) summary
      COG0484
      Location:392
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:358
      DnaJ; DnaJ domain
      pfam02809
      Location:232248
      UIM; Ubiquitin interaction motif
    5. NM_178055.4NP_835156.1  dnaJ homolog subfamily B member 2 isoform 2

      See identical proteins and their annotated locations for NP_835156.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.
      Source sequence(s)
      AK076061, BF467509, BY073498
      Consensus CDS
      CCDS35624.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000140634.1, OTTMUSP00000067718, ENSMUST00000188290.6, OTTMUST00000124481
      Conserved Domains (3) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
      pfam02809
      Location:250266
      UIM; Ubiquitin interaction motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000067.6 Reference GRCm38.p4 C57BL/6J

      Range
      75236403..75245692
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006496511.1XP_006496574.1  dnaJ homolog subfamily B member 2 isoform X1

      Conserved Domains (4) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
      pfam02809
      Location:250266
      UIM; Ubiquitin interaction motif
      pfam10254
      Location:260307
      Pacs-1; PACS-1 cytosolic sorting protein

    RNA

    1. XR_001785224.1 RNA Sequence

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