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    Dnajb2 DnaJ heat shock protein family (Hsp40) member B2 [ Mus musculus (house mouse) ]

    Gene ID: 56812, updated on 23-Jun-2021

    Summary

    Official Symbol
    Dnajb2provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B2provided by MGI
    Primary source
    MGI:MGI:1928739
    See related
    Ensembl:ENSMUSG00000026203
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Hsj1; mDj8; Dnajb; Dnajb10; 2700059H22Rik
    Expression
    Ubiquitous expression in testis adult (RPKM 63.8), cerebellum adult (RPKM 25.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dnajb2 in Genome Data Viewer
    Location:
    1; 1 C4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75213039..75222336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75236395..75245692)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 1 NC_000067.5 (75232998..75242267)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene serine/threonine kinase 16 Neighboring gene RIKEN cDNA A630095N17 gene Neighboring gene tubulin, alpha 4A Neighboring gene protein tyrosine phosphatase, receptor type, N Neighboring gene regulated endocrine-specific protein 18

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Homology

    Clone Names

    • MGC113758

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables ATPase activator activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables chaperone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables chaperone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables polyubiquitin modification-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables proteasome binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquitin-dependent protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables unfolded protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables unfolded protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in chaperone-mediated protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of cell population proliferation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of inclusion body assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of ATPase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of chaperone-mediated protein folding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein localization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in ubiquitin-dependent ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    located_in inclusion body ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in intrinsic component of endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in intrinsic component of endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    part_of proteasome complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 2
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 10
    DnaJ (Hsp40) homolog, subfamily B, member 2
    dnaJ homolog subfamily B member 10
    heat shock protein, DNAJ-like 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001159883.1NP_001153355.1  dnaJ homolog subfamily B member 2 isoform 3

      See identical proteins and their annotated locations for NP_001153355.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) represents the longest transcript and encodes the longest isoform (3).
      Source sequence(s)
      AK171494, BF467509, BY073498
      Consensus CDS
      CCDS78622.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000140566.2, ENSMUST00000188931.7
      Conserved Domains (1) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    2. NM_001159884.1NP_001153356.1  dnaJ homolog subfamily B member 2 isoform 2

      See identical proteins and their annotated locations for NP_001153356.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.
      Source sequence(s)
      AK076061, BF467509, BY073498, BY092620
      Consensus CDS
      CCDS35624.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000140588.2, ENSMUST00000188346.7
      Conserved Domains (3) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
      pfam02809
      Location:250266
      UIM; Ubiquitin interaction motif
    3. NM_001159885.1NP_001153357.1  dnaJ homolog subfamily B member 2 isoform 2

      See identical proteins and their annotated locations for NP_001153357.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR, 3' UTR, and 3' coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.
      Source sequence(s)
      AK076061, BF467509, CJ174452
      Consensus CDS
      CCDS35624.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000080796.7, ENSMUST00000082158.13
      Conserved Domains (3) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
      pfam02809
      Location:250266
      UIM; Ubiquitin interaction motif
    4. NM_020266.2NP_064662.2  dnaJ homolog subfamily B member 2 isoform 1

      See identical proteins and their annotated locations for NP_064662.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (1) lacks an internal segment and has a shorter and distinct C-terminus compared to isoform 3.
      Source sequence(s)
      AB028858, AK076061, BF467509, BY073498
      Consensus CDS
      CCDS15068.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000140637.2, ENSMUST00000187058.7
      Conserved Domains (1) summary
      COG0484
      Location:392
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    5. NM_178055.4NP_835156.1  dnaJ homolog subfamily B member 2 isoform 2

      See identical proteins and their annotated locations for NP_835156.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 3. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 3. Variants 2, 4, and 5 all encode isoform 2.
      Source sequence(s)
      AK076061, BF467509, BY073498
      Consensus CDS
      CCDS35624.1
      UniProtKB/Swiss-Prot
      Q9QYI5
      Related
      ENSMUSP00000140634.2, ENSMUST00000188290.7
      Conserved Domains (3) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam00226
      Location:366
      DnaJ; DnaJ domain
      pfam02809
      Location:250266
      UIM; Ubiquitin interaction motif

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      75213039..75222336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036152498.1XP_036008391.1  dnaJ homolog subfamily B member 2 isoform X1

      Conserved Domains (2) summary
      smart00726
      Location:291310
      UIM; Ubiquitin-interacting motif
      PRK14294
      Location:102151
      PRK14294; chaperone protein DnaJ; Provisional
    2. XM_036152499.1XP_036008392.1  dnaJ homolog subfamily B member 2 isoform X2

      Conserved Domains (2) summary
      smart00726
      Location:291310
      UIM; Ubiquitin-interacting motif
      PRK14294
      Location:102151
      PRK14294; chaperone protein DnaJ; Provisional
    3. XM_036152500.1XP_036008393.1  dnaJ homolog subfamily B member 2 isoform X3

      Conserved Domains (2) summary
      smart00726
      Location:291310
      UIM; Ubiquitin-interacting motif
      PRK14294
      Location:102151
      PRK14294; chaperone protein DnaJ; Provisional
    4. XM_036152501.1XP_036008394.1  dnaJ homolog subfamily B member 2 isoform X5

      Conserved Domains (1) summary
      COG0484
      Location:392
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    5. XM_036152502.1XP_036008395.1  dnaJ homolog subfamily B member 2 isoform X6

      Related
      ENSMUSP00000052520.8, ENSMUST00000055223.14
      Conserved Domains (1) summary
      COG0484
      Location:392
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    6. XM_006496511.2XP_006496574.1  dnaJ homolog subfamily B member 2 isoform X4

      Conserved Domains (2) summary
      COG0484
      Location:3110
      DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
      pfam02809
      Location:250266
      UIM; Ubiquitin interaction motif

    RNA

    1. XR_001785224.2 RNA Sequence

    2. XR_004933980.1 RNA Sequence

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