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    Aldh9a1 aldehyde dehydrogenase 9, subfamily A1 [ Mus musculus (house mouse) ]

    Gene ID: 56752, updated on 18-Sep-2024

    Summary

    Official Symbol
    Aldh9a1provided by MGI
    Official Full Name
    aldehyde dehydrogenase 9, subfamily A1provided by MGI
    Primary source
    MGI:MGI:1861622
    See related
    Ensembl:ENSMUSG00000026687 AllianceGenome:MGI:1861622
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Abaldh; ESTM40; Tmabadh; TMABA-DH
    Summary
    Enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor. Acts upstream of or within carnitine metabolic process. Located in cytosol. Is expressed in several structures, including alimentary system; cranium; eye; metanephros; and nervous system. Orthologous to human ALDH9A1 (aldehyde dehydrogenase 9 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 54.7), liver adult (RPKM 50.7) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Aldh9a1 in Genome Data Viewer
    Location:
    1 H2.3; 1 74.74 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (167177560..167196100)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (167349963..167368530)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9494 Neighboring gene transmembrane and coiled-coil domains 1 Neighboring gene STARR-positive B cell enhancer ABC_E9495 Neighboring gene STARR-positive B cell enhancer ABC_E10054 Neighboring gene STARR-positive B cell enhancer ABC_E8779 Neighboring gene STARR-positive B cell enhancer ABC_E2583 Neighboring gene predicted gene, 24182 Neighboring gene STARR-positive B cell enhancer ABC_E4378 Neighboring gene microsomal glutathione S-transferase 3 Neighboring gene STARR-positive B cell enhancer ABC_E4379 Neighboring gene predicted gene, 34207 Neighboring gene leucine rich repeat containing 52

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables 4-trimethylammoniobutyraldehyde dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables NAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables amine binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminobutyraldehyde dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables aminobutyraldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables aminobutyraldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables formaldehyde dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables formaldehyde dehydrogenase (NAD+) activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables small molecule binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in carnitine biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in carnitine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within carnitine metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular aldehyde metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular aldehyde metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein homotetramerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in mitochondrion HDA PubMed 

    General protein information

    Preferred Names
    4-trimethylaminobutyraldehyde dehydrogenase
    Names
    aldehyde dehydrogenase family 9 member A1
    formaldehyde dehydrogenase
    gamma-aminobutyraldehyde dehydrogenase
    NP_001389759.1
    NP_001389768.1
    NP_001389769.1
    NP_001389773.1
    NP_001389774.1
    NP_001389775.1
    NP_001392024.1
    NP_064377.2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001402830.1NP_001389759.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113970
    2. NM_001402839.1NP_001389768.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113970
    3. NM_001402840.1NP_001389769.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC113970
    4. NM_001402844.1NP_001389773.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC113970
    5. NM_001402845.1NP_001389774.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC113970
    6. NM_001402846.1NP_001389775.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC113970
      UniProtKB/TrEMBL
      Q3TG52, Q3V1N7
    7. NM_001405095.1NP_001392024.1  4-trimethylaminobutyraldehyde dehydrogenase isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC113970
    8. NM_019993.4NP_064377.2  4-trimethylaminobutyraldehyde dehydrogenase isoform 1

      See identical proteins and their annotated locations for NP_064377.2

      Status: VALIDATED

      Source sequence(s)
      AC113970
      Consensus CDS
      CCDS35765.1
      UniProtKB/TrEMBL
      Q3TG52, Q3V1N7
      Related
      ENSMUSP00000028004.10, ENSMUST00000028004.11
      Conserved Domains (1) summary
      cd07090
      Location:55512
      ALDH_F9_TMBADH; NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      167177560..167196100
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)