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    Dhodh dihydroorotate dehydrogenase [ Mus musculus (house mouse) ]

    Gene ID: 56749, updated on 22-Aug-2021

    Summary

    Official Symbol
    Dhodhprovided by MGI
    Official Full Name
    dihydroorotate dehydrogenaseprovided by MGI
    Primary source
    MGI:MGI:1928378
    See related
    Ensembl:ENSMUSG00000031730
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    AI834883; 2810417D19Rik
    Expression
    Ubiquitous expression in ovary adult (RPKM 7.7), CNS E11.5 (RPKM 7.0) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dhodh in Genome Data Viewer
    Location:
    8; 8 D3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (110319876..110335330, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (109593244..109608699, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 8 NC_000074.5 (112117148..112132573, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 39247 Neighboring gene haptoglobin Neighboring gene polycystic kidney disease 1 like 3 Neighboring gene increased sodium tolerance 1 homolog (yeast) Neighboring gene zinc finger protein 821 Neighboring gene predicted gene, 53453

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FMN binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables catalytic activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables dihydroorotase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables dihydroorotate dehydrogenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables dihydroorotate dehydrogenase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables dihydroorotate dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oxidoreductase activity, acting on the CH-CH group of donors IEA
    Inferred from Electronic Annotation
    more info
     
    enables quinone binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables ubiquinone binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in integral component of membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrial inner membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
     
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    dihydroorotate dehydrogenase (quinone), mitochondrial
    Names
    DHOdehase
    dihydroorotate dehydrogenase, mitochondrial
    dihydroorotate oxidase
    NP_064430.1
    XP_036010093.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_020046.3NP_064430.1  dihydroorotate dehydrogenase (quinone), mitochondrial precursor

      See identical proteins and their annotated locations for NP_064430.1

      Status: VALIDATED

      Source sequence(s)
      AC125162, BC045206
      Consensus CDS
      CCDS40471.1
      UniProtKB/Swiss-Prot
      O35435
      Related
      ENSMUSP00000115934.2, ENSMUST00000123605.9
      Conserved Domains (2) summary
      PLN02826
      Location:4394
      PLN02826; dihydroorotate dehydrogenase
      cd04738
      Location:43373
      DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      110319876..110335330 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154200.1XP_036010093.1  dihydroorotate dehydrogenase (quinone), mitochondrial isoform X1

      Conserved Domains (1) summary
      cd04738
      Location:2332
      DHOD_2_like; Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires ...

    RNA

    1. XR_387762.5 RNA Sequence

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