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    RETN resistin [ Homo sapiens (human) ]

    Gene ID: 56729, updated on 17-Jun-2024

    Summary

    Official Symbol
    RETNprovided by HGNC
    Official Full Name
    resistinprovided by HGNC
    Primary source
    HGNC:HGNC:20389
    See related
    Ensembl:ENSG00000104918 MIM:605565; AllianceGenome:HGNC:20389
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADSF; RENT; RSTN; XCP1; FIZZ3; RETN1
    Summary
    This gene belongs to the family defined by the mouse resistin-like genes. The characteristic feature of this family is the C-terminal stretch of 10 cys residues with identical spacing. The mouse homolog of this protein is secreted by adipocytes, and may be the hormone potentially linking obesity to type II diabetes. The encoded protein also has an antimicrobial role in skin, displaying antibacterial activity against both Gram positive and Gram negative bacteria. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2020]
    Expression
    Biased expression in bone marrow (RPKM 57.7) and lung (RPKM 6.4) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See RETN in Genome Data Viewer
    Location:
    19p13.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (7669049..7670455)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (7669929..7671334)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (7733935..7735341)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene syntaxin binding protein 2 Neighboring gene PET100 cytochrome c oxidase chaperone Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7701542-7702069 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7702070-7702598 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:7702599-7703125 Neighboring gene Purkinje cell protein 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9989 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13890 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13891 Neighboring gene RPS27A pseudogene 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13892 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9990 Neighboring gene mast cell expressed membrane protein 1 Neighboring gene Sharpr-MPRA regulatory region 435 Neighboring gene trafficking protein particle complex subunit 5 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:7749795-7749977

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Type 2 diabetes mellitus
    MedGen: C0011860 OMIM: 125853 GeneReviews: WFS1 Spectrum Disorder
    Compare labs

    EBI GWAS Catalog

    Description
    Common quantitative trait locus downstream of RETN gene identified by genome-wide association study is associated with risk of type 2 diabetes mellitus in Han Chinese: a Mendelian randomization effect.
    EBI GWAS Catalog
    Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 upregulates the expression of resistin (RETN) in peptide-treated PBMCs PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC126603, MGC126609

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables hormone activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
     
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of feeding behavior IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of progesterone secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of synaptic transmission IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to insulin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to mechanical stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in azurophil granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in specific granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    resistin
    Names
    C/EBP-epsilon regulated myeloid-specific secreted cysteine-rich protein precursor 1
    adipose tissue-specific secretory factor
    c/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein
    cysteine-rich secreted protein A12-alpha-like 2
    cysteine-rich secreted protein FIZZ3
    found in inflammatory zone 3
    resistin delta2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_023447.1 RefSeqGene

      Range
      4964..6370
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001193374.2NP_001180303.1  resistin isoform a precursor

      See identical proteins and their annotated locations for NP_001180303.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks a segment in the 5' UTR, as compared to variant 1. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC008763, AY207314
      Consensus CDS
      CCDS12182.1
      UniProtKB/Swiss-Prot
      D6W649, Q540D9, Q76B53, Q9HD89
      Conserved Domains (1) summary
      pfam06954
      Location:22106
      Resistin
    2. NM_001385725.1NP_001372654.1  resistin isoform a precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variants 1 and 2, encodes isoform a.
      Source sequence(s)
      AC008763
      Consensus CDS
      CCDS12182.1
      UniProtKB/Swiss-Prot
      D6W649, Q540D9, Q76B53, Q9HD89
      Conserved Domains (1) summary
      pfam06954
      Location:22106
      Resistin
    3. NM_001385726.1NP_001372655.1  resistin isoform b precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) encodes the longest isoform (b).
      Source sequence(s)
      AC008763
      Conserved Domains (1) summary
      pfam06954
      Location:22120
      Resistin
    4. NM_001385727.1NP_001372656.1  resistin isoform c precursor

      Status: REVIEWED

      Source sequence(s)
      AC008763
      Consensus CDS
      CCDS92503.1
      Related
      ENSP00000485998.1, ENST00000629642.1
      Conserved Domains (1) summary
      cl06143
      Location:2280
      RELM; resistin-like molecule (RELM) hormone family
    5. NM_020415.4NP_065148.1  resistin isoform a precursor

      See identical proteins and their annotated locations for NP_065148.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a. Variants 1-3 all encode the same isoform (a).
      Source sequence(s)
      AC008763, AF205952, BC069302
      Consensus CDS
      CCDS12182.1
      UniProtKB/Swiss-Prot
      D6W649, Q540D9, Q76B53, Q9HD89
      Related
      ENSP00000221515.1, ENST00000221515.6
      Conserved Domains (1) summary
      pfam06954
      Location:22106
      Resistin

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      7669049..7670455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      7669929..7671334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)