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    Plag1 pleiomorphic adenoma gene 1 [ Mus musculus (house mouse) ]

    Gene ID: 56711, updated on 9-Sep-2018

    Summary

    Official Symbol
    Plag1provided by MGI
    Official Full Name
    pleiomorphic adenoma gene 1provided by MGI
    Primary source
    MGI:MGI:1891916
    See related
    Ensembl:ENSMUSG00000003282 Vega:OTTMUSG00000004402
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Expression
    Broad expression in limb E14.5 (RPKM 2.3), CNS E11.5 (RPKM 1.2) and 15 other tissues See more
    Orthologs

    Genomic context

    See Plag1 in Genome Data Viewer
    Location:
    4; 4 A1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    106 current GRCm38.p4 (GCF_000001635.24) 4 NC_000070.6 (3898769..3938435, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 4 NC_000070.5 (3828305..3865552, complement)

    Chromosome 4 - NC_000070.6Genomic Context describing neighboring genes Neighboring gene predicted gene, 32823 Neighboring gene Moloney sarcoma oncogene Neighboring gene coiled-coil-helix-coiled-coil-helix domain containing 7 Neighboring gene ubiquitin protein ligase E3 component n-recognin 5 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    DNA-binding transcription factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    RNA polymerase II proximal promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    gland morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    multicellular organism growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    organ growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of glial cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    prostate gland growth IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    regulation of transcription, DNA-templated IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    transcription, DNA-templated IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    nuclear speck ISO
    Inferred from Sequence Orthology
    more info
     
    nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 

    General protein information

    Preferred Names
    zinc finger protein PLAG1
    Names
    C2H2 zinc finger protein PLAG1
    pleiomorphic adenoma gene 1 protein

    NCBI Reference Sequences (RefSeq)

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019969.3NP_064353.2  zinc finger protein PLAG1

      See identical proteins and their annotated locations for NP_064353.2

      Status: VALIDATED

      Source sequence(s)
      AL807387, BC139283, CJ178210
      Consensus CDS
      CCDS17941.1
      UniProtKB/Swiss-Prot
      Q9QYE0
      Related
      ENSMUSP00000003369.3, OTTMUSP00000004778, ENSMUST00000003369.9, OTTMUST00000009975
      Conserved Domains (2) summary
      sd00017
      Location:3656
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:79103
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 106

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm38.p4 C57BL/6J

    Genomic

    1. NC_000070.6 Reference GRCm38.p4 C57BL/6J

      Range
      3898769..3938435 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006538116.3XP_006538179.1  zinc finger protein PLAG1 isoform X1

      See identical proteins and their annotated locations for XP_006538179.1

      UniProtKB/Swiss-Prot
      Q9QYE0
      Conserved Domains (2) summary
      sd00017
      Location:3656
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:79103
      zf-H2C2_2; Zinc-finger double domain
    2. XM_011250079.2XP_011248381.1  zinc finger protein PLAG1 isoform X1

      See identical proteins and their annotated locations for XP_011248381.1

      UniProtKB/Swiss-Prot
      Q9QYE0
      Conserved Domains (2) summary
      sd00017
      Location:3656
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:79103
      zf-H2C2_2; Zinc-finger double domain
    3. XM_006538121.3XP_006538184.1  zinc finger protein PLAG1 isoform X3

      See identical proteins and their annotated locations for XP_006538184.1

      Conserved Domains (3) summary
      sd00017
      Location:7090
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1032
      zf-C2H2; Zinc finger, C2H2 type
      pfam15961
      Location:3860
      DUF4764; Domain of unknown function (DUF4764)
    4. XM_006538120.3XP_006538183.1  zinc finger protein PLAG1 isoform X2

      Conserved Domains (3) summary
      sd00017
      Location:7292
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1234
      zf-C2H2; Zinc finger, C2H2 type
      pfam15961
      Location:4062
      DUF4764; Domain of unknown function (DUF4764)
    5. XM_006538122.3XP_006538185.1  zinc finger protein PLAG1 isoform X3

      See identical proteins and their annotated locations for XP_006538185.1

      Conserved Domains (3) summary
      sd00017
      Location:7090
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:1032
      zf-C2H2; Zinc finger, C2H2 type
      pfam15961
      Location:3860
      DUF4764; Domain of unknown function (DUF4764)
    6. XM_017320331.1XP_017175820.1  zinc finger protein PLAG1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QYE0
      Conserved Domains (2) summary
      sd00017
      Location:3656
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:79103
      zf-H2C2_2; Zinc-finger double domain
    7. XM_017320330.1XP_017175819.1  zinc finger protein PLAG1 isoform X1

      UniProtKB/Swiss-Prot
      Q9QYE0
      Conserved Domains (2) summary
      sd00017
      Location:3656
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:79103
      zf-H2C2_2; Zinc-finger double domain
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