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    Dnajb12 DnaJ heat shock protein family (Hsp40) member B12 [ Mus musculus (house mouse) ]

    Gene ID: 56709, updated on 26-Sep-2022

    Summary

    Official Symbol
    Dnajb12provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member B12provided by MGI
    Primary source
    MGI:MGI:1931881
    See related
    Ensembl:ENSMUSG00000020109 AllianceGenome:MGI:1931881
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dj10; mDj10
    Summary
    Predicted to enable Hsp70 protein binding activity. Predicted to be involved in several processes, including cellular response to misfolded protein; chaperone cofactor-dependent protein refolding; and ubiquitin-dependent ERAD pathway. Predicted to be located in endoplasmic reticulum and nuclear membrane. Predicted to be integral component of endoplasmic reticulum membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and integumental system. Orthologous to human DNAJB12 (DnaJ heat shock protein family (Hsp40) member B12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in kidney adult (RPKM 29.5), adrenal adult (RPKM 24.3) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Dnajb12 in Genome Data Viewer
    Location:
    10; 10 B4
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (59715405..59735118)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (59879583..59899296)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene mitochondrial calcium uptake 1 Neighboring gene predicted gene, 23803 Neighboring gene predicted gene 7413 Neighboring gene predicted gene, 46226 Neighboring gene predicted gene, 40673 Neighboring gene DNA-damage-inducible transcript 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables Hsp70 protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables Hsp70 protein binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in ERAD pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to misfolded protein IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in cellular response to misfolded protein ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in chaperone cofactor-dependent protein refolding ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein-containing complex assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent ERAD pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    dnaJ homolog subfamily B member 12
    Names
    DnaJ (Hsp40) homolog, subfamily B, member 12
    DnaJ homolog 10

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001374756.1NP_001361685.1  dnaJ homolog subfamily B member 12 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC154040, AC155939
      Consensus CDS
      CCDS88010.1
      UniProtKB/TrEMBL
      A0A8C6MTS5, Q8C4C9
      Related
      ENSMUSP00000116577.2, ENSMUST00000147914.8
      Conserved Domains (2) summary
      TIGR02349
      Location:111237
      DnaJ_bact; chaperone protein DnaJ
      pfam09320
      Location:269369
      DUF1977; Domain of unknown function (DUF1977)
    2. NM_001376970.1NP_001363899.1  dnaJ homolog subfamily B member 12 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC154040, AC155939
      UniProtKB/Swiss-Prot
      Q8K037
      Related
      ENSMUSP00000020309.7, ENSMUST00000020309.7
    3. NM_019965.3NP_064349.2  dnaJ homolog subfamily B member 12 isoform 2

      See identical proteins and their annotated locations for NP_064349.2

      Status: VALIDATED

      Source sequence(s)
      AC154040, AC155939
      Consensus CDS
      CCDS23867.1
      UniProtKB/Swiss-Prot
      Q8K037, Q9QYI4
      Related
      ENSMUSP00000122056.2, ENSMUST00000146590.8
      Conserved Domains (2) summary
      pfam00226
      Location:111172
      DnaJ; DnaJ domain
      pfam09320
      Location:269369
      DUF1977; Domain of unknown function (DUF1977)

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      59715405..59735118
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)