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    PSG2 pregnancy specific beta-1-glycoprotein 2 [ Homo sapiens (human) ]

    Gene ID: 5670, updated on 5-Mar-2024

    Summary

    Official Symbol
    PSG2provided by HGNC
    Official Full Name
    pregnancy specific beta-1-glycoprotein 2provided by HGNC
    Primary source
    HGNC:HGNC:9519
    See related
    Ensembl:ENSG00000242221 MIM:176391; AllianceGenome:HGNC:9519
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CEA; PSG1; PSBG2
    Summary
    The human pregnancy-specific glycoproteins (PSGs) are a family of proteins that are synthesized in large amounts by placental trophoblasts and released into the maternal circulation during pregnancy. Molecular cloning and analysis of several PSG genes has indicated that the PSGs form a subgroup of the carcinoembryonic antigen (CEA) gene family, which belongs to the immunoglobulin superfamily of genes. Members of the CEA family consist of a single N domain, with structural similarity to the immunoglobulin variable domains, followed by a variable number of immunoglobulin constant-like A and/or B domains. Most PSGs have an arg-gly-asp (RGD) motif, which has been shown to function as an adhesion recognition signal for several integrins, in the N-terminal domain (summary by Teglund et al., 1994 [PubMed 7851896]). For additional general information about the PSG gene family, see PSG1 (MIM 176390).[supplied by OMIM, Oct 2009]
    Expression
    Restricted expression toward placenta (RPKM 263.6) See more
    Orthologs
    NEW
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    Genomic context

    See PSG2 in Genome Data Viewer
    Location:
    19q13.31
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (43064209..43082701, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (45884784..45903261, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (43568361..43586853, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene pregnancy specific beta-1-glycoprotein 11 Neighboring gene CEA cell adhesion molecule pseudogene 8 Neighboring gene CEA cell adhesion molecule pseudogene 9 Neighboring gene PSG11, PSG2 and PSG5 antisense RNA 1 Neighboring gene pregnancy specific beta-1-glycoprotein 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: PSG6

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    Process Evidence Code Pubs
    involved_in cell migration NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in female pregnancy NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cellular_component ND
    No biological Data available
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    pregnancy-specific beta-1-glycoprotein 2
    Names
    PS-beta-E
    PS-beta-G-2
    PSBG-2
    carcinoembryonic antigen SG8
    pregnancy-specific beta-1 glycoprotein E
    pregnancy-specific beta-1-glycoprotein 7
    pregnancy-specific glycoprotein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_031246.4NP_112536.2  pregnancy-specific beta-1-glycoprotein 2 precursor

      See identical proteins and their annotated locations for NP_112536.2

      Status: VALIDATED

      Source sequence(s)
      AC024077
      Consensus CDS
      CCDS12616.1
      UniProtKB/Swiss-Prot
      P11465, Q8TCD9, Q9UEA4, Q9UQ78
      UniProtKB/TrEMBL
      A0A0F7CSH9
      Related
      ENSP00000385706.1, ENST00000406487.6
      Conserved Domains (4) summary
      cd05774
      Location:36138
      Ig_CEACAM_D1; First immunoglobulin (Ig)-like domain of carcinoembryonic antigen (CEA) related cell adhesion molecule (CEACAM)
      smart00410
      Location:246318
      IG_like; Immunoglobulin like
      pfam13895
      Location:242320
      Ig_2; Immunoglobulin domain
      cl11960
      Location:148236
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      43064209..43082701 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      45884784..45903261 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)