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    Akap10 A kinase (PRKA) anchor protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 56697, updated on 23-Jun-2021

    Summary

    Official Symbol
    Akap10provided by MGI
    Official Full Name
    A kinase (PRKA) anchor protein 10provided by MGI
    Primary source
    MGI:MGI:1890218
    See related
    Ensembl:ENSMUSG00000047804
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    D-AK; PRKA10; D-AKAP2; D-AKAP-2; 1500031L16Rik; B130049N18Rik
    Summary
    This gene encodes a member of A-kinase anchoring proteins (AKAPs), a family of functionally related proteins that target protein kinase A to discrete locations within the cell. The encoded protein is localized to mitochondria and interacts with both the type I and type II regulatory subunits of PKA. It has been reported that this protein is important for maintaining heart rate and myocardial contractility through its targeting of protein kinase A. In mouse, defects of this gene lead to cardiac arrhythmias and premature death. In humans, polymorphisms in this gene may be associated with increased risk of arrhythmias and sudden cardiac death. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 4.1), frontal lobe adult (RPKM 3.5) and 28 other tissues See more
    Orthologs
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    Genomic context

    See Akap10 in Genome Data Viewer
    Location:
    11; 11 B2
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (61756029..61821134, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (61865203..61930308, complement)
    Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (61684809..61743728, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene phosphoribosyl pyrophosphate synthetase-associated protein 2 Neighboring gene unc-51 like kinase 2 Neighboring gene predicted gene, 23721 Neighboring gene predicted gene 12273

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    General gene information

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein kinase A binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase A binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    acts_upstream_of_or_within protein localization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within protein localization ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitochondrion HDA PubMed 
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    A-kinase anchor protein 10, mitochondrial
    Names
    dual specificity A kinase-anchoring protein 2
    protein kinase A-anchoring protein 10

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_019921.3NP_064305.2  A-kinase anchor protein 10, mitochondrial precursor

      See identical proteins and their annotated locations for NP_064305.2

      Status: REVIEWED

      Source sequence(s)
      AK049399, AL646042
      Consensus CDS
      CCDS24821.1
      UniProtKB/Swiss-Prot
      O88845
      Related
      ENSMUSP00000099710.4, ENSMUST00000102650.10
      Conserved Domains (3) summary
      cd08721
      Location:383503
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd08735
      Location:122367
      RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:618662
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

    RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      61756029..61821134 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533814.5XP_006533877.1  A-kinase anchor protein 10, mitochondrial isoform X1

      Conserved Domains (3) summary
      cd08721
      Location:354474
      RGS_AKAP2_2; Regulator of G protein signaling (RGS) domain 2 found in the A-kinase anchoring protein, D-AKAP2
      cd08735
      Location:93338
      RGS_AKAP2_1; Regulator of G protein signaling (RGS) domain 1 found in the A-kinase anchoring protein, D-AKAP2
      cd12804
      Location:589633
      AKAP10_AKB; PKA-binding (AKB) domain of A Kinase Anchor Protein 10

    RNA

    1. XR_879723.3 RNA Sequence

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